Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia
Transient global cerebral ischemia results in selective neuronal death in the vulnerable hippocampal CA1 pyramidal neurons in a delayed manner. Hyperglycemia accelerates and exacerbates neuronal damage in this region. The object of this study was to determine whether hyperglycemia-enhanced damage is...
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| Veröffentlicht in: | Neuroscience letters 2006-01, Vol.393 (2), p.119-121 |
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| container_end_page | 121 |
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| container_title | Neuroscience letters |
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| creator | Muranyi, Marianna Li, Ping-An |
| description | Transient global cerebral ischemia results in selective neuronal death in the vulnerable hippocampal CA1 pyramidal neurons in a delayed manner. Hyperglycemia accelerates and exacerbates neuronal damage in this region. The object of this study was to determine whether hyperglycemia-enhanced damage is associated with increased production of superoxide anion after ischemia. The results showed that hyperglycemic ischemia caused a significant increase of superoxide production in the hippocampal CA1 neurons compared to normoglycemic animals after 18
h of recirculation, suggesting that enhanced superoxide anion production may mediate the hyperglycemia-accelerated and -enhanced neuronal death in the hippocampal CA1 area after ischemia and reperfusion. |
| doi_str_mv | 10.1016/j.neulet.2005.09.079 |
| format | Article |
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h of recirculation, suggesting that enhanced superoxide anion production may mediate the hyperglycemia-accelerated and -enhanced neuronal death in the hippocampal CA1 area after ischemia and reperfusion.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Ischemia - enzymology</subject><subject>Brain Ischemia - pathology</subject><subject>Cerebral ischemia</subject><subject>Dihydroethidine</subject><subject>Disease Models, Animal</subject><subject>Ethidium - analogs & derivatives</subject><subject>Ethidium - metabolism</subject><subject>Fluorescent Antibody Technique - methods</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - enzymology</subject><subject>Hyperglycemia - pathology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Phosphopyruvate Hydratase - metabolism</subject><subject>Pyramidal Cells - enzymology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide</subject><subject>Superoxides - metabolism</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3DAURkVJaSZJ_0Ep2iQ7u1cv29oEwpAXBLJp1kKWrhMNfkwlO2T-fTXMQHZZSbo69-PjEPKLQcmAVX825YhLj3PJAVQJuoRafyMr1tS8qHXNT8gKBMhCaAmn5CylDWSQKfmDnLKKq5pxviLhYbfF-NrvHA7B0jC6iDZhomnJ8-kjeKTbOPnFzWEa8z-d35Cubxjd7qIdgrc9zT3iNCZquxkjfe2nNg8dRmxjvoTk3vbZF-R7Z_uEP4_nOXm5u_27fiienu8f1zdPhRMa5oJp57lXrW2gsxq91M5WvhHAhOKCK848yPzAFrnvvPASlOKyAa8dgqrFObk65Oba_xZMsxlyBex7O-K0JFPVqtEgVQblAXRxSiliZ7YxDDbuDAOzV2w25qDY7BUb0CYrzmu_j_lLO6D_XDo6zcDlEbDJ2b6LdnQhfXK1aESl90HXBw6zjfeA0SQXcHToQ0Q3Gz-Fr5v8B3FVnWg</recordid><startdate>20060130</startdate><enddate>20060130</enddate><creator>Muranyi, Marianna</creator><creator>Li, Ping-An</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060130</creationdate><title>Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia</title><author>Muranyi, Marianna ; Li, Ping-An</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-19cd2d5ba80fa9ed49ca6d830135232521d04013ebe2dfd3d40552480d9ce0573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Ischemia - enzymology</topic><topic>Brain Ischemia - pathology</topic><topic>Cerebral ischemia</topic><topic>Dihydroethidine</topic><topic>Disease Models, Animal</topic><topic>Ethidium - analogs & derivatives</topic><topic>Ethidium - metabolism</topic><topic>Fluorescent Antibody Technique - methods</topic><topic>Free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - enzymology</topic><topic>Hyperglycemia - pathology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Phosphopyruvate Hydratase - metabolism</topic><topic>Pyramidal Cells - enzymology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide</topic><topic>Superoxides - metabolism</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muranyi, Marianna</creatorcontrib><creatorcontrib>Li, Ping-An</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muranyi, Marianna</au><au>Li, Ping-An</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2006-01-30</date><risdate>2006</risdate><volume>393</volume><issue>2</issue><spage>119</spage><epage>121</epage><pages>119-121</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Transient global cerebral ischemia results in selective neuronal death in the vulnerable hippocampal CA1 pyramidal neurons in a delayed manner. Hyperglycemia accelerates and exacerbates neuronal damage in this region. The object of this study was to determine whether hyperglycemia-enhanced damage is associated with increased production of superoxide anion after ischemia. The results showed that hyperglycemic ischemia caused a significant increase of superoxide production in the hippocampal CA1 neurons compared to normoglycemic animals after 18
h of recirculation, suggesting that enhanced superoxide anion production may mediate the hyperglycemia-accelerated and -enhanced neuronal death in the hippocampal CA1 area after ischemia and reperfusion.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16257122</pmid><doi>10.1016/j.neulet.2005.09.079</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience letters, 2006-01, Vol.393 (2), p.119-121 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis of Variance Animals Biological and medical sciences Brain Ischemia - enzymology Brain Ischemia - pathology Cerebral ischemia Dihydroethidine Disease Models, Animal Ethidium - analogs & derivatives Ethidium - metabolism Fluorescent Antibody Technique - methods Free radicals Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Hippocampus - pathology Hyperglycemia Hyperglycemia - enzymology Hyperglycemia - pathology Immunohistochemistry Male Medical sciences Neurology Phosphopyruvate Hydratase - metabolism Pyramidal Cells - enzymology Rats Rats, Wistar Superoxide Superoxides - metabolism Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs |
| title | Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia |
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