Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting
OBJECTIVE:We investigated whether osteoprotegerin (OPG), an important regulator in the genesis of arteriosclerosis and bone formation, is able to identify patients at risk for perioperative myocardial infarction measured as cardiac troponin I (cTNI) and signs of myocardial ischemia in the electrocar...
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| Veröffentlicht in: | Critical care medicine 2006-01, Vol.34 (1), p.76-80 |
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| creator | Hermann-Arnhof, K M Kästenbauer, T Publig, T Novotny, P Loho, N Schwarz, S Köller, U Fitzgerald, R |
| description | OBJECTIVE:We investigated whether osteoprotegerin (OPG), an important regulator in the genesis of arteriosclerosis and bone formation, is able to identify patients at risk for perioperative myocardial infarction measured as cardiac troponin I (cTNI) and signs of myocardial ischemia in the electrocardiogram after coronary artery bypass grafting (CABG).
DESIGN:Observational study.
SETTING:Post-surgical intensive care unit of a tertiary care center.
PATIENTS:Ninety-seven patients undergoing elective CABG.
INTERVENTIONS:None.
MEASUREMENT AND MAIN RESULTS:OPG and cTNI were measured before and 24 hrs after CABG. Additionally, cTNI was measured after 12 hrs. Electrocardiography was done before and immediately after CABG. OPG before CABG (OPGpre) measurements correlated with cTNI measurements after 12 hrs (cTNI12) (r = 0.56; p < .0001) and with cTNI measurements after 24 hrs (cTNI24) (r = 0.77; p < .0001). OPGpre measurements correlated with electrocardiographic findings after surgery (r = 0.65; p < .0001). There was a positive correlation between OPGpre value and the number of bypasses (r = 0.95; p < .0001). A strong correlation was found between OPGpre and homocysteine (r = 0.96; p < .0001). The median OPG presurgical level for the four patients with cardiac complications was found to be notably elevated (28.1 [26.6/31.0] pmol/L) in comparison with that for patients without complications (10.2 [3.7/16.9] pmol/L).
CONCLUSIONS:OPG appears to be a useful marker for estimating risk for perioperative myocardial infarction in patients undergoing CABG, as demonstrated by signs of ischemia on electrocardiography. |
| doi_str_mv | 10.1097/01.CCM.0000190429.52746.33 |
| format | Article |
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DESIGN:Observational study.
SETTING:Post-surgical intensive care unit of a tertiary care center.
PATIENTS:Ninety-seven patients undergoing elective CABG.
INTERVENTIONS:None.
MEASUREMENT AND MAIN RESULTS:OPG and cTNI were measured before and 24 hrs after CABG. Additionally, cTNI was measured after 12 hrs. Electrocardiography was done before and immediately after CABG. OPG before CABG (OPGpre) measurements correlated with cTNI measurements after 12 hrs (cTNI12) (r = 0.56; p < .0001) and with cTNI measurements after 24 hrs (cTNI24) (r = 0.77; p < .0001). OPGpre measurements correlated with electrocardiographic findings after surgery (r = 0.65; p < .0001). There was a positive correlation between OPGpre value and the number of bypasses (r = 0.95; p < .0001). A strong correlation was found between OPGpre and homocysteine (r = 0.96; p < .0001). The median OPG presurgical level for the four patients with cardiac complications was found to be notably elevated (28.1 [26.6/31.0] pmol/L) in comparison with that for patients without complications (10.2 [3.7/16.9] pmol/L).
CONCLUSIONS:OPG appears to be a useful marker for estimating risk for perioperative myocardial infarction in patients undergoing CABG, as demonstrated by signs of ischemia on electrocardiography.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/01.CCM.0000190429.52746.33</identifier><identifier>PMID: 16374159</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; Cohort Studies ; Confidence Intervals ; Coronary Artery Bypass - adverse effects ; Coronary Artery Bypass - methods ; Coronary Disease - diagnostic imaging ; Coronary Disease - surgery ; Coronary heart disease ; Female ; Glycoproteins - blood ; Glycoproteins - metabolism ; Graft Rejection ; Graft Survival ; Heart ; Humans ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Osteoprotegerin ; Perioperative Care - methods ; Postoperative Complications - blood ; Postoperative Complications - diagnosis ; Predictive Value of Tests ; Probability ; Prognosis ; Radiography ; Receptors, Cytoplasmic and Nuclear - blood ; Receptors, Cytoplasmic and Nuclear - metabolism ; Receptors, Tumor Necrosis Factor - blood ; Receptors, Tumor Necrosis Factor - metabolism ; Risk Assessment ; Sensitivity and Specificity ; Severity of Illness Index ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Treatment Outcome</subject><ispartof>Critical care medicine, 2006-01, Vol.34 (1), p.76-80</ispartof><rights>2006 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3921-bddb39588995d06f05d3afa6e327315fe0f7e1068a323d1f82215308d3f6c9dd3</citedby><cites>FETCH-LOGICAL-c3921-bddb39588995d06f05d3afa6e327315fe0f7e1068a323d1f82215308d3f6c9dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17396948$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16374159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermann-Arnhof, K M</creatorcontrib><creatorcontrib>Kästenbauer, T</creatorcontrib><creatorcontrib>Publig, T</creatorcontrib><creatorcontrib>Novotny, P</creatorcontrib><creatorcontrib>Loho, N</creatorcontrib><creatorcontrib>Schwarz, S</creatorcontrib><creatorcontrib>Köller, U</creatorcontrib><creatorcontrib>Fitzgerald, R</creatorcontrib><title>Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>OBJECTIVE:We investigated whether osteoprotegerin (OPG), an important regulator in the genesis of arteriosclerosis and bone formation, is able to identify patients at risk for perioperative myocardial infarction measured as cardiac troponin I (cTNI) and signs of myocardial ischemia in the electrocardiogram after coronary artery bypass grafting (CABG).
DESIGN:Observational study.
SETTING:Post-surgical intensive care unit of a tertiary care center.
PATIENTS:Ninety-seven patients undergoing elective CABG.
INTERVENTIONS:None.
MEASUREMENT AND MAIN RESULTS:OPG and cTNI were measured before and 24 hrs after CABG. Additionally, cTNI was measured after 12 hrs. Electrocardiography was done before and immediately after CABG. OPG before CABG (OPGpre) measurements correlated with cTNI measurements after 12 hrs (cTNI12) (r = 0.56; p < .0001) and with cTNI measurements after 24 hrs (cTNI24) (r = 0.77; p < .0001). OPGpre measurements correlated with electrocardiographic findings after surgery (r = 0.65; p < .0001). There was a positive correlation between OPGpre value and the number of bypasses (r = 0.95; p < .0001). A strong correlation was found between OPGpre and homocysteine (r = 0.96; p < .0001). The median OPG presurgical level for the four patients with cardiac complications was found to be notably elevated (28.1 [26.6/31.0] pmol/L) in comparison with that for patients without complications (10.2 [3.7/16.9] pmol/L).
CONCLUSIONS:OPG appears to be a useful marker for estimating risk for perioperative myocardial infarction in patients undergoing CABG, as demonstrated by signs of ischemia on electrocardiography.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Coronary Artery Bypass - methods</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - surgery</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Glycoproteins - metabolism</subject><subject>Graft Rejection</subject><subject>Graft Survival</subject><subject>Heart</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoprotegerin</subject><subject>Perioperative Care - methods</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Radiography</subject><subject>Receptors, Cytoplasmic and Nuclear - blood</subject><subject>Receptors, Cytoplasmic and Nuclear - metabolism</subject><subject>Receptors, Tumor Necrosis Factor - blood</subject><subject>Receptors, Tumor Necrosis Factor - metabolism</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Treatment Outcome</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkVGP1CAQxxuj8dbTr2CIib51BabQ4pvZnHrJGV_0mbBl2KvSUoHepd_DDyx7u8nywIT8fzPDzL-q3jG6ZVS1Hynb7nbft7QcpmjD1VbwtpFbgGfVhgmgNeUKnlcbShWtoVFwVb1K6XfBG9HCy-qKSWgbJtSm-nc7DXkw3q8EPT6YjJaElDHMMWQ8YBwmkjAuIykq-kRGs5I5oh36TAyZCxDKZfLwgGRcQ2-iLeUKnYYwkZI9Fw2nnMgyWYyHMEwH0ocYJhNXYmLGEvbrbFIih2hcLvrr6oUzPuGbc7yufn25-bn7Vt_9-Hq7-3xX96A4q_fW7kGJrlNKWCodFRaMMxKBt8CEQ-paZFR2BjhY5jrOj9vpLDjZK2vhuvpwqluG_btgynocUo_emwnDkrRsRdcqIQr46QT2MaQU0ek5DmMZQDOqj55oynTxRF880U-eaICS_PbcZdmPaC-pZxMK8P4MmNQb76KZ-iFduBaUVE1XuObEPQZf1pb--OURo75H4_P9U2vgjaw5pZKy8qqPn2HwH5vIqRI</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Hermann-Arnhof, K M</creator><creator>Kästenbauer, T</creator><creator>Publig, T</creator><creator>Novotny, P</creator><creator>Loho, N</creator><creator>Schwarz, S</creator><creator>Köller, U</creator><creator>Fitzgerald, R</creator><general>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting</title><author>Hermann-Arnhof, K M ; Kästenbauer, T ; Publig, T ; Novotny, P ; Loho, N ; Schwarz, S ; Köller, U ; Fitzgerald, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-bddb39588995d06f05d3afa6e327315fe0f7e1068a323d1f82215308d3f6c9dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Coronary Artery Bypass - methods</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - surgery</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Glycoproteins - metabolism</topic><topic>Graft Rejection</topic><topic>Graft Survival</topic><topic>Heart</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Osteoprotegerin</topic><topic>Perioperative Care - methods</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Radiography</topic><topic>Receptors, Cytoplasmic and Nuclear - blood</topic><topic>Receptors, Cytoplasmic and Nuclear - metabolism</topic><topic>Receptors, Tumor Necrosis Factor - blood</topic><topic>Receptors, Tumor Necrosis Factor - metabolism</topic><topic>Risk Assessment</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermann-Arnhof, K M</creatorcontrib><creatorcontrib>Kästenbauer, T</creatorcontrib><creatorcontrib>Publig, T</creatorcontrib><creatorcontrib>Novotny, P</creatorcontrib><creatorcontrib>Loho, N</creatorcontrib><creatorcontrib>Schwarz, S</creatorcontrib><creatorcontrib>Köller, U</creatorcontrib><creatorcontrib>Fitzgerald, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermann-Arnhof, K M</au><au>Kästenbauer, T</au><au>Publig, T</au><au>Novotny, P</au><au>Loho, N</au><au>Schwarz, S</au><au>Köller, U</au><au>Fitzgerald, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>2006-01</date><risdate>2006</risdate><volume>34</volume><issue>1</issue><spage>76</spage><epage>80</epage><pages>76-80</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>OBJECTIVE:We investigated whether osteoprotegerin (OPG), an important regulator in the genesis of arteriosclerosis and bone formation, is able to identify patients at risk for perioperative myocardial infarction measured as cardiac troponin I (cTNI) and signs of myocardial ischemia in the electrocardiogram after coronary artery bypass grafting (CABG).
DESIGN:Observational study.
SETTING:Post-surgical intensive care unit of a tertiary care center.
PATIENTS:Ninety-seven patients undergoing elective CABG.
INTERVENTIONS:None.
MEASUREMENT AND MAIN RESULTS:OPG and cTNI were measured before and 24 hrs after CABG. Additionally, cTNI was measured after 12 hrs. Electrocardiography was done before and immediately after CABG. OPG before CABG (OPGpre) measurements correlated with cTNI measurements after 12 hrs (cTNI12) (r = 0.56; p < .0001) and with cTNI measurements after 24 hrs (cTNI24) (r = 0.77; p < .0001). OPGpre measurements correlated with electrocardiographic findings after surgery (r = 0.65; p < .0001). There was a positive correlation between OPGpre value and the number of bypasses (r = 0.95; p < .0001). A strong correlation was found between OPGpre and homocysteine (r = 0.96; p < .0001). The median OPG presurgical level for the four patients with cardiac complications was found to be notably elevated (28.1 [26.6/31.0] pmol/L) in comparison with that for patients without complications (10.2 [3.7/16.9] pmol/L).
CONCLUSIONS:OPG appears to be a useful marker for estimating risk for perioperative myocardial infarction in patients undergoing CABG, as demonstrated by signs of ischemia on electrocardiography.</abstract><cop>Hagerstown, MD</cop><pub>by the Society of Critical Care Medicine and Lippincott Williams & Wilkins</pub><pmid>16374159</pmid><doi>10.1097/01.CCM.0000190429.52746.33</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biomarkers - blood Cardiology. Vascular system Cohort Studies Confidence Intervals Coronary Artery Bypass - adverse effects Coronary Artery Bypass - methods Coronary Disease - diagnostic imaging Coronary Disease - surgery Coronary heart disease Female Glycoproteins - blood Glycoproteins - metabolism Graft Rejection Graft Survival Heart Humans Intensive care medicine Male Medical sciences Middle Aged Osteoprotegerin Perioperative Care - methods Postoperative Complications - blood Postoperative Complications - diagnosis Predictive Value of Tests Probability Prognosis Radiography Receptors, Cytoplasmic and Nuclear - blood Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Tumor Necrosis Factor - blood Receptors, Tumor Necrosis Factor - metabolism Risk Assessment Sensitivity and Specificity Severity of Illness Index Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Treatment Outcome |
| title | Initially elevated osteoprotegerin serum levels may predict a perioperative myocardial lesion in patients undergoing coronary artery bypass grafting |
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