The primary periodic paralyses: diagnosis, pathogenesis and treatment

Periodic paralyses (PPs) are rare inherited channelopathies that manifest as abnormal, often potassium (K)-sensitive, muscle membrane excitability leading to episodic flaccid paralysis. Hypokalaemic (HypoPP) and hyperkalaemic PP and Andersen-Tawil syndrome are genetically heterogeneous. Over the pas...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2006-01, Vol.129 (1), p.8-17
Hauptverfasser:	Venance, S. L., Cannon, S. C., Fialho, D., Fontaine, B., Hanna, M. G., Ptacek, L. J., Tristani-Firouzi, M., Tawil, R., Griggs, R. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Andersen-Tawil syndrome Animals ATS = Andersen-Tawil syndrome Biological and medical sciences Carbonic Anhydrase Inhibitors - therapeutic use channelopathy CMAP = compound motor action potential episodic weakness Genotype Human viral diseases Humans HyperPP = hyperkalaemic periodic paralysis HypoPP = hypokalaemic periodic paralysis Immunomodulators Infectious diseases Ion Channel Gating K = potassium Medical sciences Mice Mice, Knockout Models, Animal Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Mutation Neurology Paralyses, Familial Periodic - diagnosis Paralyses, Familial Periodic - drug therapy Paralyses, Familial Periodic - genetics periodic paralysis Pharmacology. Drug treatments Phenotype PMC = paramyotonia congenita Potassium - metabolism Potassium - therapeutic use Potassium Channels - genetics Potassium Channels - metabolism potassium-sensitive PP = periodic paralysis Sodium Channels - genetics Sodium Channels - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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