Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys
Aim: We investigate the effects of a 2‐month weight‐loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys. Methods: Twenty‐one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m2) completed the weight‐loss programme including: 1/ either energy restriction (R), 2/ o...
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| Veröffentlicht in: | Acta Paediatrica 2009-09, Vol.98 (9), p.1487-1493 |
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| creator | Elloumi, M Ben Ounis, O Makni, E Van Praagh, E Tabka, Z Lac, G |
| description | Aim: We investigate the effects of a 2‐month weight‐loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.
Methods: Twenty‐one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m2) completed the weight‐loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipoxmax) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
Results: Following the weight‐loss programme, adolescents of the RE group showed an improvement of their body composition (p |
| doi_str_mv | 10.1111/j.1651-2227.2009.01365.x |
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Methods: Twenty‐one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m2) completed the weight‐loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipoxmax) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
Results: Following the weight‐loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (−38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipoxmax (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA‐IR) index and Lipoxmax.
Conclusion: In obese adolescents boys, moderate exercise training completed at Lipoxmax and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA‐IR.]]></description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2009.01365.x</identifier><identifier>PMID: 19489770</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adipocyte hormones ; Adiponectin - blood ; Adolescent ; Biological and medical sciences ; Body Composition ; Caloric Restriction ; Combined Modality Therapy ; Diet, Reducing ; Energy restriction ; Exercise - physiology ; Exercise training ; Fundamental and applied biological sciences. Psychology ; General aspects ; Homeostasis ; Humans ; Leptin - blood ; Lipids - chemistry ; Male ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - blood ; Obesity - therapy ; Oxidation-Reduction ; Regression Analysis ; Resistin - blood ; Treatment Outcome ; Vertebrates: endocrinology ; Weight Loss - physiology</subject><ispartof>Acta Paediatrica, 2009-09, Vol.98 (9), p.1487-1493</ispartof><rights>2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4665-4b01e9af93f73d139f3aa82362d548bd9524baff3994428ca1af01c2543893333</citedby><cites>FETCH-LOGICAL-c4665-4b01e9af93f73d139f3aa82362d548bd9524baff3994428ca1af01c2543893333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1651-2227.2009.01365.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1651-2227.2009.01365.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21790838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19489770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elloumi, M</creatorcontrib><creatorcontrib>Ben Ounis, O</creatorcontrib><creatorcontrib>Makni, E</creatorcontrib><creatorcontrib>Van Praagh, E</creatorcontrib><creatorcontrib>Tabka, Z</creatorcontrib><creatorcontrib>Lac, G</creatorcontrib><title>Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description><![CDATA[Aim: We investigate the effects of a 2‐month weight‐loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.
Methods: Twenty‐one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m2) completed the weight‐loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipoxmax) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
Results: Following the weight‐loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (−38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipoxmax (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA‐IR) index and Lipoxmax.
Conclusion: In obese adolescents boys, moderate exercise training completed at Lipoxmax and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA‐IR.]]></description><subject>Adipocyte hormones</subject><subject>Adiponectin - blood</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Caloric Restriction</subject><subject>Combined Modality Therapy</subject><subject>Diet, Reducing</subject><subject>Energy restriction</subject><subject>Exercise - physiology</subject><subject>Exercise training</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Lipids - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - therapy</subject><subject>Oxidation-Reduction</subject><subject>Regression Analysis</subject><subject>Resistin - blood</subject><subject>Treatment Outcome</subject><subject>Vertebrates: endocrinology</subject><subject>Weight Loss - physiology</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP0zAUhS0EYkrhLyBvYEWCn7G9YFF1hgFUwSx4LC0nuR5cnKTE7UzLr8ehVVnC3Vxb_s710T0IYUpKmuv1uqSVpAVjTJWMEFMSyitZ7h-g2fnhIZoRTXghmeQX6ElKa0IYN6J6jC6oEdooRWYoXXkPzRYPHoe-DXeh3bkYfkGL7yHcft8WcUgJb8bhdnRdBwkPPXZt2Ax9VoX-FY6wyR27vsUjpJCmS4Q7iCkPxEMNCbJgiJAa6Le4Hg7pKXrkXUzw7NTn6Mvbq8_Ld8Xq0_X75WJVNKKqZCFqQsE4b7hXvKXceO6cZrxirRS6bo1konbec2OEYLpx1HlCGyYF14bnmqOXx7nZ_s8dpK3tQnYRo-th2CVbKakrwdQ_QUaUMjLveI70EWzGvJYRvN2MoXPjwVJip2Ts2k4B2CkAOyVj_yRj91n6_PTHru6g_Ss8RZGBFyfApcZFP7q-CenMMaoM0Vxn7s2Ruw8RDv9twC5uFtMp64ujPmcF-7PejT_yQriS9tvHa1t9uFzdfL1c2iX_DdY3uYI</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Elloumi, M</creator><creator>Ben Ounis, O</creator><creator>Makni, E</creator><creator>Van Praagh, E</creator><creator>Tabka, Z</creator><creator>Lac, G</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys</title><author>Elloumi, M ; Ben Ounis, O ; Makni, E ; Van Praagh, E ; Tabka, Z ; Lac, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4665-4b01e9af93f73d139f3aa82362d548bd9524baff3994428ca1af01c2543893333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipocyte hormones</topic><topic>Adiponectin - blood</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Caloric Restriction</topic><topic>Combined Modality Therapy</topic><topic>Diet, Reducing</topic><topic>Energy restriction</topic><topic>Exercise - physiology</topic><topic>Exercise training</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Lipids - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - therapy</topic><topic>Oxidation-Reduction</topic><topic>Regression Analysis</topic><topic>Resistin - blood</topic><topic>Treatment Outcome</topic><topic>Vertebrates: endocrinology</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elloumi, M</creatorcontrib><creatorcontrib>Ben Ounis, O</creatorcontrib><creatorcontrib>Makni, E</creatorcontrib><creatorcontrib>Van Praagh, E</creatorcontrib><creatorcontrib>Tabka, Z</creatorcontrib><creatorcontrib>Lac, G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elloumi, M</au><au>Ben Ounis, O</au><au>Makni, E</au><au>Van Praagh, E</au><au>Tabka, Z</au><au>Lac, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2009-09</date><risdate>2009</risdate><volume>98</volume><issue>9</issue><spage>1487</spage><epage>1493</epage><pages>1487-1493</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract><![CDATA[Aim: We investigate the effects of a 2‐month weight‐loss programme on plasma levels of adiponectin, leptin and resistin in obese adolescent boys.
Methods: Twenty‐one obese adolescent boys (BMI = 30.8 ± 3.2 kg/m2) completed the weight‐loss programme including: 1/ either energy restriction (R), 2/ or individualized exercise training at the point of maximum lipid oxidation (Lipoxmax) (E), 3/ or energy restriction and training (RE). Body composition, lipid oxidation and plasma levels of adiponectin, leptin and resistin were measured before and after intervention.
Results: Following the weight‐loss programme, adolescents of the RE group showed an improvement of their body composition (p < 0.01), an increase in plasma adiponectin (+73.7%, p < 0.01) and a decrease in plasma leptin (−38.8%, p < 0.01) leading to an increase in adiponectine/leptin ratio (ALR, +144.4%, p < 0.01) higher than the R or E groups. E and RE groups only showed a similar significant increase in plasma resistin (p < 0.05) and a significant improvement of lipid oxidation rate at Lipoxmax (p < 0.01 and p < 0.001). In addition, in RE group, ALR is correlated with waist/hip and waist/height ratios, resistin level, homoeostasis mode assessment (HOMA‐IR) index and Lipoxmax.
Conclusion: In obese adolescents boys, moderate exercise training completed at Lipoxmax and combined with energy restriction improves their ability to oxidize lipids, which is associated with a normalization of their adiponectin, leptin and resistin levels resulting in an improved insulin sensitivity, as attested by a higher ALR and a lower HOMA‐IR.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19489770</pmid><doi>10.1111/j.1651-2227.2009.01365.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adipocyte hormones Adiponectin - blood Adolescent Biological and medical sciences Body Composition Caloric Restriction Combined Modality Therapy Diet, Reducing Energy restriction Exercise - physiology Exercise training Fundamental and applied biological sciences. Psychology General aspects Homeostasis Humans Leptin - blood Lipids - chemistry Male Medical sciences Metabolic diseases Obesity Obesity - blood Obesity - therapy Oxidation-Reduction Regression Analysis Resistin - blood Treatment Outcome Vertebrates: endocrinology Weight Loss - physiology |
| title | Effect of individualized weight-loss programmes on adiponectin, leptin and resistin levels in obese adolescent boys |
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