Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori
Background: An increased number of intraepithelial lymphocytes (IELs) can be the only histological feature in early stages of celiac disease (CD). This is also presented in duodenum of patients with Helicobacter pylori‐associated gastritis and in autoimmune diseases. Because CD is frequently associa...
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| Veröffentlicht in: | Pediatric diabetes 2009-08, Vol.10 (5), p.316-320 |
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| description | Background: An increased number of intraepithelial lymphocytes (IELs) can be the only histological feature in early stages of celiac disease (CD). This is also presented in duodenum of patients with Helicobacter pylori‐associated gastritis and in autoimmune diseases. Because CD is frequently associated with type 1 diabetes mellitus, we analyzed the density of IELs in the distal duodenum of non‐celiac diabetic patients associated or not with H.pylori infection.
Methods: IEL density and the presence of H.pylori were determined in biopsies of the distal duodenum and gastric antrum and body obtained from Brazilian diabetic adolescents who were negative for anti‐human tissue transglutaminase and anti‐endomysial. The results were compared with the histological findings of gastric and duodenal biopsies obtained from non‐diabetic older children and adolescents.
Results: H.
pylori was detected in 33.3% of diabetic patients and in 56.7% of the control group. No association was observed between the presence of H.pylori and an increased lymphocyte density in the distal duodenum in either group. Diabetic patients presented a duodenal IEL density similar to that of the control group. Lymphocytic gastritis was not identified in any of the biopsies analyzed.
Conclusions: The density of IELs in the distal duodenum of diabetic adolescents did not differ from that observed in older children and adolescents without this autoimmune disease. H.pylori infection, which is frequent among adolescents from developing countries, did not modify lymphocyte density in the distal duodenum in the absence of lymphocytic gastritis. |
| doi_str_mv | 10.1111/j.1399-5448.2008.00478.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67586376</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67586376</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4368-b308ddad953556b044090deae32870936a1820c93aec32ef957aaf1085c7d0923</originalsourceid><addsrcrecordid>eNqNkUFv1DAUhCMEoqXwF5BP3BLsOIntAwdoy3ZRBUgFFXGxHPtF9eLEwU7UTX99vexqOYIvHsnzzbM9WYYILkhabzcFoULkdVXxosSYFxhXjBfbJ9np8eDpUdMfJ9mLGDcYEyZo9Tw7ISLJkpen2bIepqBgtNMdOKsccks_3nm9TBCRHZCZvYFh7lEXfI8-BPVgk21AyngHUcMwRXSfYDQtIyCCjFUtJLZA66FzMwwakO_QVQrXvlV6goDGxflgX2bPOuUivDrsZ9n3j5ffzq_y6y-r9fn761xXtOF5SzE3RhlR07puWlxVWGADCmjJGRa0UYSXWAuqQNMSOlEzpTqCea2ZwaKkZ9mbfe4Y_O8Z4iR7my7unBrAz1E2rOYNZc0_jSVmTJCaJiPfG3XwMQbo5Bhsr8IiCZa7fuRG7r5e7mqQu37kn37kNqGvDzPmtgfzFzwUkgzv9oZ762D572D59fJinVTi8z1v4wTbI6_Cr_RQymp5-3klyaeL1erm5qe8pY8kcq_L</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20779153</pqid></control><display><type>article</type><title>Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Cabral, Virgínia Lúcia Ribeiro ; Patrício, Francy Reis Da Silva ; Gabbay, Mônica Andrade Lima ; Dib, Sérgio Atala ; Miszputen, Sender Jankiel</creator><creatorcontrib>Cabral, Virgínia Lúcia Ribeiro ; Patrício, Francy Reis Da Silva ; Gabbay, Mônica Andrade Lima ; Dib, Sérgio Atala ; Miszputen, Sender Jankiel</creatorcontrib><description>Background: An increased number of intraepithelial lymphocytes (IELs) can be the only histological feature in early stages of celiac disease (CD). This is also presented in duodenum of patients with Helicobacter pylori‐associated gastritis and in autoimmune diseases. Because CD is frequently associated with type 1 diabetes mellitus, we analyzed the density of IELs in the distal duodenum of non‐celiac diabetic patients associated or not with H.pylori infection.
Methods: IEL density and the presence of H.pylori were determined in biopsies of the distal duodenum and gastric antrum and body obtained from Brazilian diabetic adolescents who were negative for anti‐human tissue transglutaminase and anti‐endomysial. The results were compared with the histological findings of gastric and duodenal biopsies obtained from non‐diabetic older children and adolescents.
Results: H.
pylori was detected in 33.3% of diabetic patients and in 56.7% of the control group. No association was observed between the presence of H.pylori and an increased lymphocyte density in the distal duodenum in either group. Diabetic patients presented a duodenal IEL density similar to that of the control group. Lymphocytic gastritis was not identified in any of the biopsies analyzed.
Conclusions: The density of IELs in the distal duodenum of diabetic adolescents did not differ from that observed in older children and adolescents without this autoimmune disease. H.pylori infection, which is frequent among adolescents from developing countries, did not modify lymphocyte density in the distal duodenum in the absence of lymphocytic gastritis.</description><identifier>ISSN: 1399-543X</identifier><identifier>EISSN: 1399-5448</identifier><identifier>DOI: 10.1111/j.1399-5448.2008.00478.x</identifier><identifier>PMID: 19017282</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescence ; Adolescent ; Autoimmune diseases ; Biopsy ; Brazil ; Celiac disease ; Children ; Developing countries ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - microbiology ; Diabetes Mellitus, Type 1 - pathology ; Duodenum ; Duodenum - cytology ; Duodenum - pathology ; Female ; Gastritis ; Gastritis - immunology ; Gastritis - microbiology ; Gastritis - pathology ; Helicobacter Infections - immunology ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori ; Helicobacter pylori - growth & development ; Helicobacter pylori - immunology ; Humans ; IELs ; Immunohistochemistry ; Infection ; Lymphocyte Count ; Lymphocytes ; Lymphocytosis - immunology ; Lymphocytosis - microbiology ; Lymphocytosis - pathology ; Male ; Pediatrics ; Transglutaminase 2</subject><ispartof>Pediatric diabetes, 2009-08, Vol.10 (5), p.316-320</ispartof><rights>2008 The Authors. Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4368-b308ddad953556b044090deae32870936a1820c93aec32ef957aaf1085c7d0923</citedby><cites>FETCH-LOGICAL-c4368-b308ddad953556b044090deae32870936a1820c93aec32ef957aaf1085c7d0923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-5448.2008.00478.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-5448.2008.00478.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19017282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabral, Virgínia Lúcia Ribeiro</creatorcontrib><creatorcontrib>Patrício, Francy Reis Da Silva</creatorcontrib><creatorcontrib>Gabbay, Mônica Andrade Lima</creatorcontrib><creatorcontrib>Dib, Sérgio Atala</creatorcontrib><creatorcontrib>Miszputen, Sender Jankiel</creatorcontrib><title>Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori</title><title>Pediatric diabetes</title><addtitle>Pediatr Diabetes</addtitle><description>Background: An increased number of intraepithelial lymphocytes (IELs) can be the only histological feature in early stages of celiac disease (CD). This is also presented in duodenum of patients with Helicobacter pylori‐associated gastritis and in autoimmune diseases. Because CD is frequently associated with type 1 diabetes mellitus, we analyzed the density of IELs in the distal duodenum of non‐celiac diabetic patients associated or not with H.pylori infection.
Methods: IEL density and the presence of H.pylori were determined in biopsies of the distal duodenum and gastric antrum and body obtained from Brazilian diabetic adolescents who were negative for anti‐human tissue transglutaminase and anti‐endomysial. The results were compared with the histological findings of gastric and duodenal biopsies obtained from non‐diabetic older children and adolescents.
Results: H.
pylori was detected in 33.3% of diabetic patients and in 56.7% of the control group. No association was observed between the presence of H.pylori and an increased lymphocyte density in the distal duodenum in either group. Diabetic patients presented a duodenal IEL density similar to that of the control group. Lymphocytic gastritis was not identified in any of the biopsies analyzed.
Conclusions: The density of IELs in the distal duodenum of diabetic adolescents did not differ from that observed in older children and adolescents without this autoimmune disease. H.pylori infection, which is frequent among adolescents from developing countries, did not modify lymphocyte density in the distal duodenum in the absence of lymphocytic gastritis.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Autoimmune diseases</subject><subject>Biopsy</subject><subject>Brazil</subject><subject>Celiac disease</subject><subject>Children</subject><subject>Developing countries</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - microbiology</subject><subject>Diabetes Mellitus, Type 1 - pathology</subject><subject>Duodenum</subject><subject>Duodenum - cytology</subject><subject>Duodenum - pathology</subject><subject>Female</subject><subject>Gastritis</subject><subject>Gastritis - immunology</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - growth & development</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>IELs</subject><subject>Immunohistochemistry</subject><subject>Infection</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes</subject><subject>Lymphocytosis - immunology</subject><subject>Lymphocytosis - microbiology</subject><subject>Lymphocytosis - pathology</subject><subject>Male</subject><subject>Pediatrics</subject><subject>Transglutaminase 2</subject><issn>1399-543X</issn><issn>1399-5448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAUhCMEoqXwF5BP3BLsOIntAwdoy3ZRBUgFFXGxHPtF9eLEwU7UTX99vexqOYIvHsnzzbM9WYYILkhabzcFoULkdVXxosSYFxhXjBfbJ9np8eDpUdMfJ9mLGDcYEyZo9Tw7ISLJkpen2bIepqBgtNMdOKsccks_3nm9TBCRHZCZvYFh7lEXfI8-BPVgk21AyngHUcMwRXSfYDQtIyCCjFUtJLZA66FzMwwakO_QVQrXvlV6goDGxflgX2bPOuUivDrsZ9n3j5ffzq_y6y-r9fn761xXtOF5SzE3RhlR07puWlxVWGADCmjJGRa0UYSXWAuqQNMSOlEzpTqCea2ZwaKkZ9mbfe4Y_O8Z4iR7my7unBrAz1E2rOYNZc0_jSVmTJCaJiPfG3XwMQbo5Bhsr8IiCZa7fuRG7r5e7mqQu37kn37kNqGvDzPmtgfzFzwUkgzv9oZ762D572D59fJinVTi8z1v4wTbI6_Cr_RQymp5-3klyaeL1erm5qe8pY8kcq_L</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Cabral, Virgínia Lúcia Ribeiro</creator><creator>Patrício, Francy Reis Da Silva</creator><creator>Gabbay, Mônica Andrade Lima</creator><creator>Dib, Sérgio Atala</creator><creator>Miszputen, Sender Jankiel</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori</title><author>Cabral, Virgínia Lúcia Ribeiro ; Patrício, Francy Reis Da Silva ; Gabbay, Mônica Andrade Lima ; Dib, Sérgio Atala ; Miszputen, Sender Jankiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4368-b308ddad953556b044090deae32870936a1820c93aec32ef957aaf1085c7d0923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Autoimmune diseases</topic><topic>Biopsy</topic><topic>Brazil</topic><topic>Celiac disease</topic><topic>Children</topic><topic>Developing countries</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - microbiology</topic><topic>Diabetes Mellitus, Type 1 - pathology</topic><topic>Duodenum</topic><topic>Duodenum - cytology</topic><topic>Duodenum - pathology</topic><topic>Female</topic><topic>Gastritis</topic><topic>Gastritis - immunology</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - growth & development</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>IELs</topic><topic>Immunohistochemistry</topic><topic>Infection</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes</topic><topic>Lymphocytosis - immunology</topic><topic>Lymphocytosis - microbiology</topic><topic>Lymphocytosis - pathology</topic><topic>Male</topic><topic>Pediatrics</topic><topic>Transglutaminase 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabral, Virgínia Lúcia Ribeiro</creatorcontrib><creatorcontrib>Patrício, Francy Reis Da Silva</creatorcontrib><creatorcontrib>Gabbay, Mônica Andrade Lima</creatorcontrib><creatorcontrib>Dib, Sérgio Atala</creatorcontrib><creatorcontrib>Miszputen, Sender Jankiel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric diabetes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabral, Virgínia Lúcia Ribeiro</au><au>Patrício, Francy Reis Da Silva</au><au>Gabbay, Mônica Andrade Lima</au><au>Dib, Sérgio Atala</au><au>Miszputen, Sender Jankiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori</atitle><jtitle>Pediatric diabetes</jtitle><addtitle>Pediatr Diabetes</addtitle><date>2009-08</date><risdate>2009</risdate><volume>10</volume><issue>5</issue><spage>316</spage><epage>320</epage><pages>316-320</pages><issn>1399-543X</issn><eissn>1399-5448</eissn><abstract>Background: An increased number of intraepithelial lymphocytes (IELs) can be the only histological feature in early stages of celiac disease (CD). This is also presented in duodenum of patients with Helicobacter pylori‐associated gastritis and in autoimmune diseases. Because CD is frequently associated with type 1 diabetes mellitus, we analyzed the density of IELs in the distal duodenum of non‐celiac diabetic patients associated or not with H.pylori infection.
Methods: IEL density and the presence of H.pylori were determined in biopsies of the distal duodenum and gastric antrum and body obtained from Brazilian diabetic adolescents who were negative for anti‐human tissue transglutaminase and anti‐endomysial. The results were compared with the histological findings of gastric and duodenal biopsies obtained from non‐diabetic older children and adolescents.
Results: H.
pylori was detected in 33.3% of diabetic patients and in 56.7% of the control group. No association was observed between the presence of H.pylori and an increased lymphocyte density in the distal duodenum in either group. Diabetic patients presented a duodenal IEL density similar to that of the control group. Lymphocytic gastritis was not identified in any of the biopsies analyzed.
Conclusions: The density of IELs in the distal duodenum of diabetic adolescents did not differ from that observed in older children and adolescents without this autoimmune disease. H.pylori infection, which is frequent among adolescents from developing countries, did not modify lymphocyte density in the distal duodenum in the absence of lymphocytic gastritis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19017282</pmid><doi>10.1111/j.1399-5448.2008.00478.x</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescence Adolescent Autoimmune diseases Biopsy Brazil Celiac disease Children Developing countries Diabetes mellitus Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 1 - pathology Duodenum Duodenum - cytology Duodenum - pathology Female Gastritis Gastritis - immunology Gastritis - microbiology Gastritis - pathology Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - growth & development Helicobacter pylori - immunology Humans IELs Immunohistochemistry Infection Lymphocyte Count Lymphocytes Lymphocytosis - immunology Lymphocytosis - microbiology Lymphocytosis - pathology Male Pediatrics Transglutaminase 2 |
| title | Intraepithelial lymphocytes in duodenum from Brazilian adolescents with type 1 diabetes. Influence of Helicobacter pylori |
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