Post-ischemic leakiness of the blood–brain barrier: A quantitative and systematic assessment by Patlak plots

The Patlak plot analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) allows estimation of blood–brain barrier (BBB) leakage following temporary focal cerebral ischemia. Thus far, a systematic and quantitative in vivo evaluation of post-ischemic BBB leakage is lacking. Here, usi...

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Veröffentlicht in:	Experimental neurology 2009-09, Vol.219 (1), p.328-333
Hauptverfasser:	Abo-Ramadan, Usama, Durukan, Aysan, Pitkonen, Miia, Marinkovic, Ivan, Tatlisumak, Ertugrul, Pedrono, Eric, Soinne, Lauri, Strbian, Daniel, Tatlisumak, Turgut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BBB (blood–brain barrier) Biological and medical sciences Blood-Brain Barrier - pathology Blood-Brain Barrier - physiopathology Brain Edema - etiology Brain Edema - pathology Brain Edema - physiopathology Brain Ischemia - complications Brain Ischemia - pathology Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - physiology Contrast Media Disease Progression Focal ischemia Fundamental and applied biological sciences. Psychology Gadolinium Image Interpretation, Computer-Assisted - methods Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Laser-Doppler Flowmetry Magnetic Resonance Imaging - methods Male Medical sciences MRI (magnetic resonance imaging) Neurology Rat Rats Rats, Wistar Recovery of Function - physiology Reperfusion Injury - pathology Reperfusion Injury - physiopathology Time Factors Vertebrates: nervous system and sense organs
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