Phthalic acid diamides activate ryanodine-sensitive Ca2+ release channels in insects

Flubendiamide represents a novel chemical family of substituted phthalic acid diamides with potent insecticidal activity. So far, the molecular target and the mechanism of action were not known. Here we present for the first time evidence that phthalic acid diamides activate ryanodine-sensitive intr...

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Veröffentlicht in:	Cell calcium (Edinburgh) 2006-01, Vol.39 (1), p.21-33
Hauptverfasser:	Ebbinghaus-Kintscher, Ulrich, Luemmen, Peter, Lobitz, Nicole, Schulte, Thomas, Funke, Christian, Fischer, Rüdiger, Masaki, Takao, Yasokawa, Noriaki, Tohnishi, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzamides - pharmacology Caffeine - pharmacology Calcium - metabolism Cell Line CHO Cells Cricetinae Cytosol - metabolism Diamide - pharmacology Drosophila melanogaster Fura-2 Intracellular Membranes - chemistry Macrocyclic Compounds Mice Microscopy, Fluorescence Moths - metabolism Muscles - chemistry Muscles - metabolism Neurons - metabolism Oxazoles - pharmacology Ryanodine - metabolism Ryanodine Receptor Calcium Release Channel - drug effects Ryanodine Receptor Calcium Release Channel - metabolism Sulfones - pharmacology Transfection
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