Premature immunosenescence in HIV-infected patients on highly active antiretroviral therapy with low-level CD4 T cell repopulation

Objectives To analyse the role of thymic function and its association with cellular immunosenescence markers in patients with low-level CD4 T cell repopulation, despite complete HIV RNA replication control on highly active antiretroviral therapy (HAART). Methods Cellular immunosenescence markers com...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2009-09, Vol.64 (3), p.579-588
Hauptverfasser:	Molina-Pinelo, Sonia, Vallejo, Alejandro, Díaz, Laura, Soriano-Sarabia, Natalia, Ferrando-Martínez, Sara, Resino, Salvador, Muñoz-Fernández, María Ángeles, Leal, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Adult Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretroviral Therapy, Highly Active - methods Apoptosis Biological and medical sciences Biomarkers - analysis CD4 Lymphocyte Count CD4 T cells CD4-Positive T-Lymphocytes - immunology Drug therapy Female HAART HIV HIV - immunology HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Immune system Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lymphocyte Activation Lymphocytes Male Medical sciences Middle Aged Pharmacology. Drug treatments senescence thymic function Thymus Gland - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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