RSV replication is attenuated by counteracting expression of the suppressor of cytokine signaling (SOCS) molecules

Abstract Human RSV causes an annual epidemic of respiratory tract illness in infants and in elderly. Mechanisms by which RSV antagonizes IFN-mediated antiviral responses include inhibition of type I IFN mRNA transcription and blocking signal transduction of JAK/STAT family members. The suppressor of...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2009-09, Vol.391 (2), p.162-170
Hauptverfasser:	Hashimoto, Koichi, Ishibashi, Kei, Ishioka, Ken, Zhao, Dongchi, Sato, Masatoki, Ohara, Shinichiro, Abe, Yusaku, Kawasaki, Yukihiko, Sato, Yuka, Yokota, Shin-ichi, Fujii, Nobuhiro, Peebles, Ray Stokes, Hosoya, Mitsuaki, Suzutani, Tatsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cytokines - antagonists & inhibitors Epithelial Cells - virology Gene Expression Profiling Gene Knockdown Techniques - methods Gene Silencing Humans IFN Infectious Disease JAK/STAT Respiratory Syncytial Viruses - immunology Respiratory Syncytial Viruses - physiology RNA, Small Interfering - genetics RSV siRNA SOCS Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - biosynthesis Up-Regulation Virus Replication
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