Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: Verification and complementation of hypotheses derived from transcriptomics

The physiological effects of genetic and transcriptional changes observed in a phenol producing mutant of the solvent-tolerant Pseudomonas putida S12 were assessed with metabolic flux analysis. The upregulation of a malate/lactate dehydrogenase encoding gene could be connected to a flux increase fro...

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Veröffentlicht in:	Journal of biotechnology 2009-08, Vol.143 (2), p.124-129
Hauptverfasser:	Wierckx, Nick, Ruijssenaars, Harald J., de Winde, Johannes H., Schmid, Andreas, Blank, Lars M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Bacterial Proteins - metabolism Biological and medical sciences Biotechnology Carbon Encoding Fermentation Flux Fluxes Fundamental and applied biological sciences. Psychology Gene Expression Profiling - methods Genes Gluconates - metabolism Glucose - metabolism Malate Membrane Transport Proteins - metabolism Metabolic engineering Metabolic flux analysis Metabolic Networks and Pathways NADP - metabolism Phenol Phenols - metabolism Porins - metabolism Pseudomonas putida Pseudomonas putida - genetics Pseudomonas putida - growth & development Pseudomonas putida - metabolism Pseudomonas putida S12 Pyruvate Kinase - metabolism Solvent tolerance Systems Biology - methods
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