Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

The vitamin D receptor (VDR) and its ligand 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] are required for normal keratinocyte differentiation. Both the epidermis and the hair follicle are disrupted in VDR-null mice. Hairless (Hr), a presumptive transcription factor with no known ligand, when mutated, disr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2006-01, Vol.147 (1), p.314-323
Hauptverfasser:	Xie, Zhongjian, Chang, Sandra, Oda, Yuko, Bikle, Daniel D
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Animals Biological and medical sciences Calciferol Calcitriol Cell Line Chromatin Chromatin - genetics Chromatin - ultrastructure Differentiation DNA Primers Electrophoretic mobility Epidermis Follicles Fundamental and applied biological sciences. Psychology Genes Hair Hairless Humans Immunoprecipitation Keratinocytes Keratinocytes - physiology Kidney Ligands Phospholipase C Polymerase Chain Reaction Receptors Receptors, Calcitriol - genetics Transcription Factors - physiology Transcriptional Activation Vertebrates: endocrinology Vitamin D Vitamin D receptors Vitamin D3 Zinc Fingers
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!