Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells

Replication-competent oncolytic viruses are being developed for human cancer therapy. We previously reported that an attenuated adenovirus OBP-301 (Telomelysin), in which the human telomerase reverse transcriptase promoter element drives expression of E1A and E1B genes linked with an internal riboso...

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Veröffentlicht in:	Experimental cell research 2006-02, Vol.312 (3), p.256-265
Hauptverfasser:	Watanabe, Takanori, Hioki, Masayoshi, Fujiwara, Toshiya, Nishizaki, Masahiko, Kagawa, Shunsuke, Taki, Masaki, Kishimoto, Hiroyuki, Endo, Yoshikatsu, Urata, Yasuo, Tanaka, Noriaki, Fujiwara, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae Infections - metabolism Adenoviridae Infections - therapy Adenovirus Adenovirus E1 Proteins - genetics Antibiotics, Antineoplastic - pharmacology CAR Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - therapy Cell Cycle - drug effects Cell Line, Tumor Cell Survival Coxsackie and Adenovirus Receptor-Like Membrane Protein Depsipeptides - pharmacology DNA-Binding Proteins - genetics Enzyme Inhibitors - pharmacology Flow Cytometry Genetic Therapy - methods Green Fluorescent Proteins - metabolism HDAC inhibitor Histone Deacetylase Inhibitors Humans Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - therapy Oncolytic virus Oncolytic Viruses - genetics Promoter Regions, Genetic Receptors, Virus - metabolism Telomerase - genetics Virus Replication - drug effects
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