Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study
presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of presenilin-2 has recently been reported to be...
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| Veröffentlicht in: | Journal of the neurological sciences 2006-01, Vol.240 (1), p.71-75 |
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| container_title | Journal of the neurological sciences |
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| creator | Quan, Wenxiang Yasuda, Minoru Hashimoto, Mamoru Yamamoto, Yasuji Ishii, Kazunari Kazui, Hiroaki Mori, Etsuro Kakigi, Tatsuya Maeda, Kiyoshi |
| description | presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the
apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of
presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the
presenilin-2 gene polymorphism and the
apolipoprotein E genotype in an extended case-control study.
We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis.
The
presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the
presenilin-2 polymorphism and the
apolipoprotein E ε4 allele.
Our results fail to support an association of
presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences. |
| doi_str_mv | 10.1016/j.jns.2005.09.004 |
| format | Article |
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apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of
presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the
presenilin-2 gene polymorphism and the
apolipoprotein E genotype in an extended case-control study.
We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis.
The
presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the
presenilin-2 polymorphism and the
apolipoprotein E ε4 allele.
Our results fail to support an association of
presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/j.jns.2005.09.004</identifier><identifier>PMID: 16233903</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease - genetics ; Alzheimer's disease ; Apolipoprotein E4 ; Apolipoproteins E - genetics ; Biological and medical sciences ; Case-Control Studies ; Case-control study ; Chi-Square Distribution ; Confidence Intervals ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; DNA Mutational Analysis - methods ; Female ; Gene Frequency ; Genotype ; Humans ; Male ; Medical sciences ; Membrane Proteins - genetics ; Middle Aged ; Neurology ; Odds Ratio ; Polymorphism ; Polymorphism, Genetic ; Presenilin-2 ; Regulatory region ; Regulatory Sequences, Nucleic Acid - genetics ; Retrospective Studies ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Journal of the neurological sciences, 2006-01, Vol.240 (1), p.71-75</ispartof><rights>2005 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4285f507e128f700ae3ba13e730c67d63f420088e6acf858ec080ae1077f23c63</citedby><cites>FETCH-LOGICAL-c447t-4285f507e128f700ae3ba13e730c67d63f420088e6acf858ec080ae1077f23c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jns.2005.09.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17379007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16233903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quan, Wenxiang</creatorcontrib><creatorcontrib>Yasuda, Minoru</creatorcontrib><creatorcontrib>Hashimoto, Mamoru</creatorcontrib><creatorcontrib>Yamamoto, Yasuji</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kazui, Hiroaki</creatorcontrib><creatorcontrib>Mori, Etsuro</creatorcontrib><creatorcontrib>Kakigi, Tatsuya</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><title>Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the
apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of
presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the
presenilin-2 gene polymorphism and the
apolipoprotein E genotype in an extended case-control study.
We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis.
The
presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the
presenilin-2 polymorphism and the
apolipoprotein E ε4 allele.
Our results fail to support an association of
presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Case-control study</subject><subject>Chi-Square Distribution</subject><subject>Confidence Intervals</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>DNA Mutational Analysis - methods</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Presenilin-2</subject><subject>Regulatory region</subject><subject>Regulatory Sequences, Nucleic Acid - genetics</subject><subject>Retrospective Studies</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EotvCD-CCfIGeEsZxEjv0tKr4kirBASRulutMul4ldvAkSMuvx6td1BunGWmedzTzMPZKQClAtO_25T5QWQE0JXQlQP2EbYRWumi0lk_ZBqCqikbAzwt2SbQHgFbr7jm7EG0lZQdyw5ZvcTxMMc07TxOPA192yBM-rKNdYjocWx_Dv8GckDD40Yei4g8YkPvAaY7J9t7x7fhnh37CdE2894SW8D3fcpdr4WJYUhw5LWt_eMGeDXYkfHmuV-zHxw_fbz8Xd18_fbnd3hWurtVS1JVuhgYUikoPCsCivLdCopLgWtW3cqjz71pja92gG40OdIYEKDVU0rXyir097Z1T_LUiLWby5HAcbcC4kmlVo0XX6gyKE-hSJEo4mDn5yaaDEWCOqs3eZNXmqNpAZ7LqnHl9Xr7eT9g_Js5uM_DmDFhydhySDc7TI6ek6gBU5m5OHGYVvz0mQ85jcNj7hG4xffT_OeMvSPWcjg</recordid><startdate>20060115</startdate><enddate>20060115</enddate><creator>Quan, Wenxiang</creator><creator>Yasuda, Minoru</creator><creator>Hashimoto, Mamoru</creator><creator>Yamamoto, Yasuji</creator><creator>Ishii, Kazunari</creator><creator>Kazui, Hiroaki</creator><creator>Mori, Etsuro</creator><creator>Kakigi, Tatsuya</creator><creator>Maeda, Kiyoshi</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060115</creationdate><title>Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study</title><author>Quan, Wenxiang ; Yasuda, Minoru ; Hashimoto, Mamoru ; Yamamoto, Yasuji ; Ishii, Kazunari ; Kazui, Hiroaki ; Mori, Etsuro ; Kakigi, Tatsuya ; Maeda, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4285f507e128f700ae3ba13e730c67d63f420088e6acf858ec080ae1077f23c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E4</topic><topic>Apolipoproteins E - genetics</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Case-control study</topic><topic>Chi-Square Distribution</topic><topic>Confidence Intervals</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>DNA Mutational Analysis - methods</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Presenilin-2</topic><topic>Regulatory region</topic><topic>Regulatory Sequences, Nucleic Acid - genetics</topic><topic>Retrospective Studies</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quan, Wenxiang</creatorcontrib><creatorcontrib>Yasuda, Minoru</creatorcontrib><creatorcontrib>Hashimoto, Mamoru</creatorcontrib><creatorcontrib>Yamamoto, Yasuji</creatorcontrib><creatorcontrib>Ishii, Kazunari</creatorcontrib><creatorcontrib>Kazui, Hiroaki</creatorcontrib><creatorcontrib>Mori, Etsuro</creatorcontrib><creatorcontrib>Kakigi, Tatsuya</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quan, Wenxiang</au><au>Yasuda, Minoru</au><au>Hashimoto, Mamoru</au><au>Yamamoto, Yasuji</au><au>Ishii, Kazunari</au><au>Kazui, Hiroaki</au><au>Mori, Etsuro</au><au>Kakigi, Tatsuya</au><au>Maeda, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2006-01-15</date><risdate>2006</risdate><volume>240</volume><issue>1</issue><spage>71</spage><epage>75</epage><pages>71-75</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>presenilin-2 is one of the causative genes for familial Alzheimer's disease, and the
apolipoprotein E ε4 allele is a major genetic risk factor for late-onset and sporadic early-onset Alzheimer's disease. Polymorphism of the regulatory region of
presenilin-2 has recently been reported to be associated with sporadic Alzheimer's disease in a Russian population. The purpose of this study was to determine whether Alzheimer's disease is associated with the
presenilin-2 gene polymorphism and the
apolipoprotein E genotype in an extended case-control study.
We examined 230 patients with Alzheimer's disease, along with an equal number of age- and sex-matched controls from the same community, in a Japanese population by using a Chi-square test for homogeneity and a logistic regression analysis.
The
presenilin-2 polymorphism frequencies were similar in early-onset Alzheimer's disease patients (0.17) and younger controls (0.15), and in late-onset Alzheimer's disease (0.20) and elderly controls (0.20). We found no evidence for an association between the
presenilin-2 polymorphism and the
apolipoprotein E ε4 allele.
Our results fail to support an association of
presenilin-2 gene polymorphism with Alzheimer's disease. The discrepancy between our results and the results of the Russian study appear to be due to racial differences.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>16233903</pmid><doi>10.1016/j.jns.2005.09.004</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the neurological sciences, 2006-01, Vol.240 (1), p.71-75 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Age Factors Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 Apolipoproteins E - genetics Biological and medical sciences Case-Control Studies Case-control study Chi-Square Distribution Confidence Intervals Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis - methods Female Gene Frequency Genotype Humans Male Medical sciences Membrane Proteins - genetics Middle Aged Neurology Odds Ratio Polymorphism Polymorphism, Genetic Presenilin-2 Regulatory region Regulatory Sequences, Nucleic Acid - genetics Retrospective Studies Tumors of the nervous system. Phacomatoses |
| title | Polymorphism of the regulatory region of the presenilin-2 gene in sporadic Alzheimer's disease: A case-control study |
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