The CD8+ T Cell Population Elicited by Recombinant Adenovirus Displays a Novel Partially Exhausted Phenotype Associated with Prolonged Antigen Presentation That Nonetheless Provides Long-Term Immunity

We have previously reported that the CD8+ T cell response elicited by recombinant adenovirus vaccination displayed a delayed contraction in the spleen. In our current study, we demonstrate that this unusual kinetic is a general phenomenon observed in multiple tissues. Phenotypic analysis of transgen...

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Veröffentlicht in:	The Journal of immunology (1950) 2006-01, Vol.176 (1), p.200-210
Hauptverfasser:	Yang, Teng-Chih, Millar, James, Groves, Timothy, Grinshtein, Natalie, Parsons, Robin, Takenaka, Shunsuke, Wan, Yonghong, Bramson, Jonathan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - immunology Adoptive Transfer Animals Antigen Presentation - immunology Antigens, Viral - immunology CD8-Positive T-Lymphocytes - immunology Egg Proteins - immunology Female Flow Cytometry Genetic Vectors - administration & dosage Genetic Vectors - immunology Immunophenotyping Lymph Nodes - immunology Mice Ovalbumin - immunology Peptide Fragments Time Factors Transgenes
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