Doxycycline Modulates Nitric Oxide Production in Murine Lung Epithelial Cells

Many effective therapeutic agents exhibit effects that are different from their intended primary mode of action. Antibiotics such as doxycycline and erythromycin A are no exception. They also display anti-inflammatory activity. Using LA4 murine lung alveolar epithelial cells, effects of doxycycline...

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Veröffentlicht in:	Journal of Immunology 2006-01, Vol.176 (1), p.567-572
Hauptverfasser:	Hoyt, Jeffrey C, Ballering, Janelle, Numanami, Hiroki, Hayden, John M, Robbins, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Blotting, Western Cell Line Dose-Response Relationship, Drug Doxycycline - pharmacology Electrophoresis, Polyacrylamide Gel Epithelial Cells - drug effects Epithelial Cells - metabolism Erythromycin - pharmacology Mice NF-kappa B - drug effects NF-kappa B - metabolism Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - drug effects Nitrites - metabolism p38 Mitogen-Activated Protein Kinases - drug effects p38 Mitogen-Activated Protein Kinases - metabolism Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Transcription Factor AP-1 - drug effects Transcription Factor AP-1 - metabolism
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