The Local Anesthetic Butamben Inhibits and Accelerates Low-Voltage Activated T-Type Currents in Small Sensory Neurons

Butamben (BAB) is a local anesthetic that can be used in epidural suspensions for long-term selective suppression of dorsal root pain signal transmission and in ointments for the treatment of skin pain. Previously, high-voltage activated N-type calcium channel inhibition has been implicated in the a...

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Veröffentlicht in:	Anesthesia and analgesia 2006-01, Vol.102 (1), p.141-145
Hauptverfasser:	Beekwilder, Jeroen P., van Kempen, Gertrudis Th.H., van den Berg, Rutgeris J., Ypey, Dirk L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Local Animals Animals, Newborn Benzocaine - analogs & derivatives Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channels, T-Type - metabolism Calcium Channels, T-Type - physiology Cells, Cultured Dose-Response Relationship, Drug Medical sciences Mice Neurons, Afferent - drug effects Neurons, Afferent - physiology
Online-Zugang:	Volltext
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