CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge
Despite their close physical and functional relationships, alveolar macrophages (AMs) and pulmonary dendritic cells (pulDCs) have rarely been examined together in the context of infection. Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae we d...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-01, Vol.193 (2), p.205-213 |
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| creator | Kirby, Alun C. Raynes, John G. Kaye, Paul M. |
| description | Despite their close physical and functional relationships, alveolar macrophages (AMs) and pulmonary dendritic cells (pulDCs) have rarely been examined together in the context of infection. Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae we demonstrate that AMs and pulDCs exhibit distinct characteristics during pulmonary inflammation. Recruitment of AMs and pulDCs occurred with different kinetics, and increased numbers of AMs resulted mainly from the appearance of a distinct subset of CD11bHigh AMs. Increased numbers of CD11bHigh and CD11bLow AMs, but not pulDCs, were recoverable from bronchoalveolar lavage fluid. CD11b expression on AMs was significantly increased by granulocyte-macrophage colony-stimulating factor but not by interleukin-10 or pathogen-associated stimuli. Finally, antibody blockade demonstrated that CD11b was critical for the recruitment of AMs, but not pulDCs, into the lung after pneumococcal challenge. These data demonstrate that there are significant differences between AM and pulDC responses to inflammatory pathogenic stimuli in vivo |
| doi_str_mv | 10.1086/498874 |
| format | Article |
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Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae we demonstrate that AMs and pulDCs exhibit distinct characteristics during pulmonary inflammation. Recruitment of AMs and pulDCs occurred with different kinetics, and increased numbers of AMs resulted mainly from the appearance of a distinct subset of CD11bHigh AMs. Increased numbers of CD11bHigh and CD11bLow AMs, but not pulDCs, were recoverable from bronchoalveolar lavage fluid. CD11b expression on AMs was significantly increased by granulocyte-macrophage colony-stimulating factor but not by interleukin-10 or pathogen-associated stimuli. Finally, antibody blockade demonstrated that CD11b was critical for the recruitment of AMs, but not pulDCs, into the lung after pneumococcal challenge. 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Psychology ; Granulocyte-Macrophage Colony-Stimulating Factor - immunology ; Infections ; Infectious diseases ; Interleukin-10 - immunology ; Lung - immunology ; Lungs ; Macrophages, Alveolar - immunology ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microbiology ; Miscellaneous ; Monocytes ; Physiological regulation ; Pneumonia, Pneumococcal - immunology ; Pulmonary alveoli ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology</subject><ispartof>The Journal of infectious diseases, 2006-01, Vol.193 (2), p.205-213</ispartof><rights>Copyright 2006 Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2007 INIST-CNRS</rights><rights>Copyright University of Chicago Press Jan 15, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-ad0e10bfe5defe6da7d51392a9d86a81150775f6ce0a97ac71151aba09737ce63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086463$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086463$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18764169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16362884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirby, Alun C.</creatorcontrib><creatorcontrib>Raynes, John G.</creatorcontrib><creatorcontrib>Kaye, Paul M.</creatorcontrib><title>CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>Despite their close physical and functional relationships, alveolar macrophages (AMs) and pulmonary dendritic cells (pulDCs) have rarely been examined together in the context of infection. Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae we demonstrate that AMs and pulDCs exhibit distinct characteristics during pulmonary inflammation. Recruitment of AMs and pulDCs occurred with different kinetics, and increased numbers of AMs resulted mainly from the appearance of a distinct subset of CD11bHigh AMs. Increased numbers of CD11bHigh and CD11bLow AMs, but not pulDCs, were recoverable from bronchoalveolar lavage fluid. CD11b expression on AMs was significantly increased by granulocyte-macrophage colony-stimulating factor but not by interleukin-10 or pathogen-associated stimuli. Finally, antibody blockade demonstrated that CD11b was critical for the recruitment of AMs, but not pulDCs, into the lung after pneumococcal challenge. These data demonstrate that there are significant differences between AM and pulDC responses to inflammatory pathogenic stimuli in vivo</description><subject>Alveolar macrophages</subject><subject>Animals</subject><subject>Antigens</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>CD11b Antigen - biosynthesis</subject><subject>CD11b Antigen - physiology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Disease Models, Animal</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - immunology</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interleukin-10 - immunology</subject><subject>Lung - immunology</subject><subject>Lungs</subject><subject>Macrophages, Alveolar - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Monocytes</subject><subject>Physiological regulation</subject><subject>Pneumonia, Pneumococcal - immunology</subject><subject>Pulmonary alveoli</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VGL1DAQB_Aiiree-g2UnKBv1UzTJunj0fXuhFMXURBfyjSd7nVtmzVJRb-9ObrcgiA-JWR-TJL_JMlT4K-Ba_kmL7VW-b1kBYVQqZQg7icrzrMsBV2WJ8kj73ec81xI9TA5ASlkpnW-Sly1BmjYJ9rOAwbycWfc3IeRpsBsx86Hn2QHdOw9Gmf3N7iNppkD-2AD28zDaCd0v9maptb1oTesomHwDLtAjm0mmkdrrDE4sOoGh4GmLT1OHnQ4eHpyWE-TLxdvP1dX6fXHy3fV-XVqci1Cii0n4E1HRUsdyRZVW4AoMyxbLVEDFFypopOGOJYKjYongA3yUgllSIrT5NXSd-_sj5l8qMfem_g8nMjOvpaq0By0-i8ElasM9G3HF3_BnZ3dFD9RZ5kouQDIj91iXt476uq968cYUg28vp1VvcwqwueHbnMzUntkh-FE8PIA0McEO4eT6f3RaSVzkGV0Z4uz8_7flz1bzM4H6-6U4NHkUsR6utR7H-jXXR3d95iTUEV99fVbvYaLvLrc8FqIPz1CvVE</recordid><startdate>20060115</startdate><enddate>20060115</enddate><creator>Kirby, Alun C.</creator><creator>Raynes, John G.</creator><creator>Kaye, Paul M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060115</creationdate><title>CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge</title><author>Kirby, Alun C. ; Raynes, John G. ; Kaye, Paul M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-ad0e10bfe5defe6da7d51392a9d86a81150775f6ce0a97ac71151aba09737ce63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alveolar macrophages</topic><topic>Animals</topic><topic>Antigens</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>CD11b Antigen - biosynthesis</topic><topic>CD11b Antigen - physiology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - immunology</topic><topic>Disease Models, Animal</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - immunology</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interleukin-10 - immunology</topic><topic>Lung - immunology</topic><topic>Lungs</topic><topic>Macrophages, Alveolar - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Monocytes</topic><topic>Physiological regulation</topic><topic>Pneumonia, Pneumococcal - immunology</topic><topic>Pulmonary alveoli</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirby, Alun C.</creatorcontrib><creatorcontrib>Raynes, John G.</creatorcontrib><creatorcontrib>Kaye, Paul M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirby, Alun C.</au><au>Raynes, John G.</au><au>Kaye, Paul M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>2006-01-15</date><risdate>2006</risdate><volume>193</volume><issue>2</issue><spage>205</spage><epage>213</epage><pages>205-213</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Despite their close physical and functional relationships, alveolar macrophages (AMs) and pulmonary dendritic cells (pulDCs) have rarely been examined together in the context of infection. Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae we demonstrate that AMs and pulDCs exhibit distinct characteristics during pulmonary inflammation. Recruitment of AMs and pulDCs occurred with different kinetics, and increased numbers of AMs resulted mainly from the appearance of a distinct subset of CD11bHigh AMs. Increased numbers of CD11bHigh and CD11bLow AMs, but not pulDCs, were recoverable from bronchoalveolar lavage fluid. CD11b expression on AMs was significantly increased by granulocyte-macrophage colony-stimulating factor but not by interleukin-10 or pathogen-associated stimuli. Finally, antibody blockade demonstrated that CD11b was critical for the recruitment of AMs, but not pulDCs, into the lung after pneumococcal challenge. 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| subjects | Alveolar macrophages Animals Antigens Bacteria Bacteriology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology CD11b Antigen - biosynthesis CD11b Antigen - physiology Dendritic cells Dendritic Cells - immunology Disease Models, Animal Flow Cytometry Fundamental and applied biological sciences. Psychology Granulocyte-Macrophage Colony-Stimulating Factor - immunology Infections Infectious diseases Interleukin-10 - immunology Lung - immunology Lungs Macrophages, Alveolar - immunology Medical sciences Mice Mice, Inbred C57BL Microbiology Miscellaneous Monocytes Physiological regulation Pneumonia, Pneumococcal - immunology Pulmonary alveoli Streptococcus pneumoniae Streptococcus pneumoniae - immunology |
| title | CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge |
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