Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ultrasound surgery
Abstract Objective To demonstrate the safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatments regardless of the distance between the treatment region and the uterine serosa. Study design 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2009-09, Vol.146 (1), p.92-95 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Morita, Yutaka Takeuchi, Sawako Hikida, Hiromi Ohashi, Hirofumi Ito, Naoki |
| description | Abstract Objective To demonstrate the safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatments regardless of the distance between the treatment region and the uterine serosa. Study design 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in 88 treatments. Treatment data was analyzed, measuring the distance between the treatment spots (sonications) and the serosa. Patients were followed up for 1 year and adverse events were collected. Results 79% and 37% of the sonications were less than 15 mm and 10 mm from the serosa, respectively. Treatment was always confined to the fibroid capsule. There were no unexpected or serious adverse events. Conclusion Reducing the margin between the fibroid treatment area and the uterine serosa, when possible, enables MRgFUS treatment of greater fibroid volume, while maintaining a high safety profile. Special attention should be paid when the uterus lies adjacent to other sensitive organs to avoid unintentional heating of these organs, using the planning and real-time MR images. |
| doi_str_mv | 10.1016/j.ejogrb.2009.05.004 |
| format | Article |
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Study design 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in 88 treatments. Treatment data was analyzed, measuring the distance between the treatment spots (sonications) and the serosa. Patients were followed up for 1 year and adverse events were collected. Results 79% and 37% of the sonications were less than 15 mm and 10 mm from the serosa, respectively. Treatment was always confined to the fibroid capsule. There were no unexpected or serious adverse events. Conclusion Reducing the margin between the fibroid treatment area and the uterine serosa, when possible, enables MRgFUS treatment of greater fibroid volume, while maintaining a high safety profile. Special attention should be paid when the uterus lies adjacent to other sensitive organs to avoid unintentional heating of these organs, using the planning and real-time MR images.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2009.05.004</identifier><identifier>PMID: 19481328</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Leiomyoma - diagnostic imaging ; Leiomyoma - surgery ; Magnetic Resonance Imaging, Interventional - methods ; Medical sciences ; MRgFUS ; Obstetrics and Gynecology ; Serosa ; Serous Membrane - diagnostic imaging ; Serous Membrane - surgery ; Sonication ; Tumors ; Ultrasonic Therapy - methods ; Ultrasonography ; Uterine fibroids ; Uterine Neoplasms - diagnostic imaging ; Uterine Neoplasms - surgery ; Uterus - surgery</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2009-09, Vol.146 (1), p.92-95</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-31a166c85d5aecf9e0a144912109b46027bf7a0e0eafd400622fc0ada7f175003</citedby><cites>FETCH-LOGICAL-c445t-31a166c85d5aecf9e0a144912109b46027bf7a0e0eafd400622fc0ada7f175003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211509003145$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21897141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19481328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morita, Yutaka</creatorcontrib><creatorcontrib>Takeuchi, Sawako</creatorcontrib><creatorcontrib>Hikida, Hiromi</creatorcontrib><creatorcontrib>Ohashi, Hirofumi</creatorcontrib><creatorcontrib>Ito, Naoki</creatorcontrib><title>Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ultrasound surgery</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective To demonstrate the safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatments regardless of the distance between the treatment region and the uterine serosa. Study design 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in 88 treatments. Treatment data was analyzed, measuring the distance between the treatment spots (sonications) and the serosa. Patients were followed up for 1 year and adverse events were collected. Results 79% and 37% of the sonications were less than 15 mm and 10 mm from the serosa, respectively. Treatment was always confined to the fibroid capsule. There were no unexpected or serious adverse events. Conclusion Reducing the margin between the fibroid treatment area and the uterine serosa, when possible, enables MRgFUS treatment of greater fibroid volume, while maintaining a high safety profile. Special attention should be paid when the uterus lies adjacent to other sensitive organs to avoid unintentional heating of these organs, using the planning and real-time MR images.</description><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Leiomyoma - diagnostic imaging</subject><subject>Leiomyoma - surgery</subject><subject>Magnetic Resonance Imaging, Interventional - methods</subject><subject>Medical sciences</subject><subject>MRgFUS</subject><subject>Obstetrics and Gynecology</subject><subject>Serosa</subject><subject>Serous Membrane - diagnostic imaging</subject><subject>Serous Membrane - surgery</subject><subject>Sonication</subject><subject>Tumors</subject><subject>Ultrasonic Therapy - methods</subject><subject>Ultrasonography</subject><subject>Uterine fibroids</subject><subject>Uterine Neoplasms - diagnostic imaging</subject><subject>Uterine Neoplasms - surgery</subject><subject>Uterus - surgery</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkstu1DAUhiMEotPCGyDkDewSjhPntkFChQJSJRbA2nLs44xDxi6-FM278LA4mlGR2OCNN9_5bX3_KYoXFCoKtHuzVLi42U9VDTBW0FYA7FGxo0Nfl33XssfFDhqgZU1pe1FchrBAPk0zPi0u6MgG2tTDrvj9HqVHEYydyUH42dhAoiNxjyRF9MYiCehdEEQEIsgB494pop0nxj4MbvS9W9MBidNEm8k7ozI-rSKiIr9M3Ofw2WI0kngMzgorsZyTUbiFyRTyndboRXDJKhKSn9EfnxVPtFgDPj_fV8X3mw_frj-Vt18-fr5-d1tKxtpYNlTQrpNDq1qBUo8IgjI20prCOLEO6n7SvQAEFFoxgK6utQShRK9p32YnV8XrU-6ddz8ThsgPJkhcV2HRpcC7vu3HYRgzyE6gzEqCR83vvMnajpwC31rhCz-1wrdWOLQ8t5LHXp7z03RA9XfoXEMGXp0BEaRYtc9-THjgajqMPWU0c29PHGYb9wY9D9JgdqmMRxm5cuZ_P_k3QK7GmvzmDzxiWFzyNpvmlIeaA_-6bdC2QDBmTZS1zR_6MsUI</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Morita, Yutaka</creator><creator>Takeuchi, Sawako</creator><creator>Hikida, Hiromi</creator><creator>Ohashi, Hirofumi</creator><creator>Ito, Naoki</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ultrasound surgery</title><author>Morita, Yutaka ; Takeuchi, Sawako ; Hikida, Hiromi ; Ohashi, Hirofumi ; Ito, Naoki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-31a166c85d5aecf9e0a144912109b46027bf7a0e0eafd400622fc0ada7f175003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Leiomyoma - diagnostic imaging</topic><topic>Leiomyoma - surgery</topic><topic>Magnetic Resonance Imaging, Interventional - methods</topic><topic>Medical sciences</topic><topic>MRgFUS</topic><topic>Obstetrics and Gynecology</topic><topic>Serosa</topic><topic>Serous Membrane - diagnostic imaging</topic><topic>Serous Membrane - surgery</topic><topic>Sonication</topic><topic>Tumors</topic><topic>Ultrasonic Therapy - methods</topic><topic>Ultrasonography</topic><topic>Uterine fibroids</topic><topic>Uterine Neoplasms - diagnostic imaging</topic><topic>Uterine Neoplasms - surgery</topic><topic>Uterus - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morita, Yutaka</creatorcontrib><creatorcontrib>Takeuchi, Sawako</creatorcontrib><creatorcontrib>Hikida, Hiromi</creatorcontrib><creatorcontrib>Ohashi, Hirofumi</creatorcontrib><creatorcontrib>Ito, Naoki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morita, Yutaka</au><au>Takeuchi, Sawako</au><au>Hikida, Hiromi</au><au>Ohashi, Hirofumi</au><au>Ito, Naoki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ultrasound surgery</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>146</volume><issue>1</issue><spage>92</spage><epage>95</epage><pages>92-95</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Abstract Objective To demonstrate the safety of magnetic resonance-guided focused ultrasound surgery (MRgFUS) treatments regardless of the distance between the treatment region and the uterine serosa. Study design 83 pre-menopausal women with symptomatic uterine fibroids were treated with MRgFUS in 88 treatments. Treatment data was analyzed, measuring the distance between the treatment spots (sonications) and the serosa. Patients were followed up for 1 year and adverse events were collected. Results 79% and 37% of the sonications were less than 15 mm and 10 mm from the serosa, respectively. Treatment was always confined to the fibroid capsule. There were no unexpected or serious adverse events. Conclusion Reducing the margin between the fibroid treatment area and the uterine serosa, when possible, enables MRgFUS treatment of greater fibroid volume, while maintaining a high safety profile. Special attention should be paid when the uterus lies adjacent to other sensitive organs to avoid unintentional heating of these organs, using the planning and real-time MR images.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19481328</pmid><doi>10.1016/j.ejogrb.2009.05.004</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Leiomyoma - diagnostic imaging Leiomyoma - surgery Magnetic Resonance Imaging, Interventional - methods Medical sciences MRgFUS Obstetrics and Gynecology Serosa Serous Membrane - diagnostic imaging Serous Membrane - surgery Sonication Tumors Ultrasonic Therapy - methods Ultrasonography Uterine fibroids Uterine Neoplasms - diagnostic imaging Uterine Neoplasms - surgery Uterus - surgery |
| title | Decreasing margins to the uterine serosa as a method for increasing the volume of fibroids ablated with magnetic resonance-guided focused ultrasound surgery |
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