A Bridge Crosses the Active-Site Canyon of the Epstein–Barr Virus Nuclease with DNase and RNase Activities

Epstein–Barr virus, a double-stranded DNA (dsDNA) virus, is a major human pathogen from the herpesvirus family. The nuclease is one of the lytic cycle proteins required for successful viral replication. In addition to the previously described endonuclease and exonuclease activities on single-strande...

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Veröffentlicht in:	Journal of molecular biology 2009-08, Vol.391 (4), p.717-728
Hauptverfasser:	Buisson, Marlyse, Géoui, Thibault, Flot, David, Tarbouriech, Nicolas, Ressing, Maaike E., Wiertz, Emmanuel J., Burmeister, Wim P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Catalytic Domain Crystal structure Crystallography, X-Ray Cycle protein Deoxyribonuclease Deoxyribonucleases - chemistry Deoxyribonucleases - genetics Deoxyribonucleases - metabolism DNA - chemistry DNA - metabolism Endonuclease Endonucleases - chemistry Endonucleases - genetics Endonucleases - metabolism Epstein-Barr virus exonuclease Exonucleases - chemistry Exonucleases - genetics Exonucleases - metabolism Herpesvirus Herpesvirus 4, Human - enzymology Herpesvirus 4, Human - pathogenicity Humans Models, Molecular Molecular Sequence Data Molecular Structure mRNA Nuclease Pathogens Phages Protein Conformation Replication Ribonuclease Ribonucleases - chemistry Ribonucleases - genetics Ribonucleases - metabolism Sequence Alignment Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism
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