Probing the Drosophila retinal determination gene network in Tribolium ( II): The Pax6 genes eyeless and twin of eyeless
The Pax6 genes eyeless ( ey) and twin of eyeless ( toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is...
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Veröffentlicht in: | Developmental biology 2009-09, Vol.333 (1), p.215-227 |
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creator | Yang, Xiaoyun Weber, Markus ZarinKamar, Nazanin Posnien, Nico Friedrich, Frank Wigand, Barbara Beutel, Rolf Damen, Wim G.M. Bucher, Gregor Klingler, Martin Friedrich, Markus |
description | The
Pax6 genes
eyeless (
ey) and
twin of eyeless (
toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in
Drosophila. Most animals possess a singleton
Pax6 ortholog, but the dependence of eye development on
Pax6 is widely conserved. A rare exception is given by the larval eyes of
Drosophila, which develop independently of
ey and
toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of
toy and
ey in the red flour beetle
Tribolium castaneum. We find that single and combinatorial knockdown of
toy and
ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when
ey and
toy were RNAi-silenced in combination with the early retinal gene
dachshund (
dac). We propose that these data reflect a role of
Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of
toy,
ey and
dac in
Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that
Tribolium represents an ancestral state of redundant control by
ey and
toy. |
doi_str_mv | 10.1016/j.ydbio.2009.06.013 |
format | Article |
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Pax6 genes
eyeless (
ey) and
twin of eyeless (
toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in
Drosophila. Most animals possess a singleton
Pax6 ortholog, but the dependence of eye development on
Pax6 is widely conserved. A rare exception is given by the larval eyes of
Drosophila, which develop independently of
ey and
toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of
toy and
ey in the red flour beetle
Tribolium castaneum. We find that single and combinatorial knockdown of
toy and
ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when
ey and
toy were RNAi-silenced in combination with the early retinal gene
dachshund (
dac). We propose that these data reflect a role of
Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of
toy,
ey and
dac in
Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that
Tribolium represents an ancestral state of redundant control by
ey and
toy.</description><identifier>ISSN: 0012-1606</identifier><identifier>EISSN: 1095-564X</identifier><identifier>DOI: 10.1016/j.ydbio.2009.06.013</identifier><identifier>PMID: 19527703</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Compound Eye, Arthropod - embryology ; Compound Eye, Arthropod - growth & development ; Compound Eye, Arthropod - metabolism ; Conserved Sequence ; Dachshund ; DNA-Binding Proteins - genetics ; Drosophila ; Drosophila - genetics ; Drosophila Proteins - genetics ; Evolution of development ; Eye development ; Eye Proteins - genetics ; Eyeless ; Gene Knockdown Techniques ; Gene Regulatory Networks ; Homeodomain Proteins - genetics ; Insect Proteins - biosynthesis ; Insect Proteins - genetics ; Molecular Sequence Data ; Paired Box Transcription Factors - genetics ; PAX6 Transcription Factor ; Redundancy ; Repressor Proteins - genetics ; Retinal determination gene network ; Trans-Activators - genetics ; Tribolium ; Tribolium - embryology ; Tribolium - genetics ; Tribolium - growth & development ; Tribolium - metabolism ; Twin of eyeless</subject><ispartof>Developmental biology, 2009-09, Vol.333 (1), p.215-227</ispartof><rights>2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-8ffd79537c2da0028ec95446c9777b1d0bae649d60bd629df0ebc220cb5d2f653</citedby><cites>FETCH-LOGICAL-c454t-8ffd79537c2da0028ec95446c9777b1d0bae649d60bd629df0ebc220cb5d2f653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ydbio.2009.06.013$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19527703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xiaoyun</creatorcontrib><creatorcontrib>Weber, Markus</creatorcontrib><creatorcontrib>ZarinKamar, Nazanin</creatorcontrib><creatorcontrib>Posnien, Nico</creatorcontrib><creatorcontrib>Friedrich, Frank</creatorcontrib><creatorcontrib>Wigand, Barbara</creatorcontrib><creatorcontrib>Beutel, Rolf</creatorcontrib><creatorcontrib>Damen, Wim G.M.</creatorcontrib><creatorcontrib>Bucher, Gregor</creatorcontrib><creatorcontrib>Klingler, Martin</creatorcontrib><creatorcontrib>Friedrich, Markus</creatorcontrib><title>Probing the Drosophila retinal determination gene network in Tribolium ( II): The Pax6 genes eyeless and twin of eyeless</title><title>Developmental biology</title><addtitle>Dev Biol</addtitle><description>The
Pax6 genes
eyeless (
ey) and
twin of eyeless (
toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in
Drosophila. Most animals possess a singleton
Pax6 ortholog, but the dependence of eye development on
Pax6 is widely conserved. A rare exception is given by the larval eyes of
Drosophila, which develop independently of
ey and
toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of
toy and
ey in the red flour beetle
Tribolium castaneum. We find that single and combinatorial knockdown of
toy and
ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when
ey and
toy were RNAi-silenced in combination with the early retinal gene
dachshund (
dac). We propose that these data reflect a role of
Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of
toy,
ey and
dac in
Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that
Tribolium represents an ancestral state of redundant control by
ey and
toy.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Compound Eye, Arthropod - embryology</subject><subject>Compound Eye, Arthropod - growth & development</subject><subject>Compound Eye, Arthropod - metabolism</subject><subject>Conserved Sequence</subject><subject>Dachshund</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drosophila</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins - genetics</subject><subject>Evolution of development</subject><subject>Eye development</subject><subject>Eye Proteins - genetics</subject><subject>Eyeless</subject><subject>Gene Knockdown Techniques</subject><subject>Gene Regulatory Networks</subject><subject>Homeodomain Proteins - genetics</subject><subject>Insect Proteins - biosynthesis</subject><subject>Insect Proteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>Paired Box Transcription Factors - genetics</subject><subject>PAX6 Transcription Factor</subject><subject>Redundancy</subject><subject>Repressor Proteins - genetics</subject><subject>Retinal determination gene network</subject><subject>Trans-Activators - genetics</subject><subject>Tribolium</subject><subject>Tribolium - embryology</subject><subject>Tribolium - genetics</subject><subject>Tribolium - growth & development</subject><subject>Tribolium - metabolism</subject><subject>Twin of eyeless</subject><issn>0012-1606</issn><issn>1095-564X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFrFDEUx4Modq1-AkFyEj3M-JKZJBvBg1RbFwr2sIK3MJO8abPOTNYka7vf3rS74k1PeYTf___g_Qh5yaBmwOS7Tb13vQ81B9A1yBpY84gsGGhRCdl-f0wWAIxXTII8Ic9S2gBAs1w2T8kJ04IrBc2C3F3F0Pv5muYbpJ9iSGF748eORsx-7kbqMGOcyph9mOk1zkhnzLch_qB-puvo-zD63UTf0NXq7Xu6Li1X3Z18IBPFPY6YEu1mR_NtCYThz99z8mToxoQvju8p-Xb-eX32pbr8erE6-3hZ2Va0uVoOg1NaNMpy1wHwJVot2lZarZTqmYO-Q9lqJ6F3kms3APaWc7C9cHyQojklrw-92xh-7jBlM_lkcRy7GcMuGamE0oX7L8hBaS44L2BzAG05V4o4mG30Uxf3hoG5N2M25sGMuTdjQJpipqReHet3_YTub-aoogAfDgCWa_zyGE2yHmeLzke02bjg_7ngN-NSoQo</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Yang, Xiaoyun</creator><creator>Weber, Markus</creator><creator>ZarinKamar, Nazanin</creator><creator>Posnien, Nico</creator><creator>Friedrich, Frank</creator><creator>Wigand, Barbara</creator><creator>Beutel, Rolf</creator><creator>Damen, Wim G.M.</creator><creator>Bucher, Gregor</creator><creator>Klingler, Martin</creator><creator>Friedrich, Markus</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Probing the Drosophila retinal determination gene network in Tribolium ( II): The Pax6 genes eyeless and twin of eyeless</title><author>Yang, Xiaoyun ; Weber, Markus ; ZarinKamar, Nazanin ; Posnien, Nico ; Friedrich, Frank ; Wigand, Barbara ; Beutel, Rolf ; Damen, Wim G.M. ; Bucher, Gregor ; Klingler, Martin ; Friedrich, Markus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-8ffd79537c2da0028ec95446c9777b1d0bae649d60bd629df0ebc220cb5d2f653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Compound Eye, Arthropod - embryology</topic><topic>Compound Eye, Arthropod - growth & development</topic><topic>Compound Eye, Arthropod - metabolism</topic><topic>Conserved Sequence</topic><topic>Dachshund</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drosophila</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins - genetics</topic><topic>Evolution of development</topic><topic>Eye development</topic><topic>Eye Proteins - genetics</topic><topic>Eyeless</topic><topic>Gene Knockdown Techniques</topic><topic>Gene Regulatory Networks</topic><topic>Homeodomain Proteins - genetics</topic><topic>Insect Proteins - biosynthesis</topic><topic>Insect Proteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>Paired Box Transcription Factors - genetics</topic><topic>PAX6 Transcription Factor</topic><topic>Redundancy</topic><topic>Repressor Proteins - genetics</topic><topic>Retinal determination gene network</topic><topic>Trans-Activators - genetics</topic><topic>Tribolium</topic><topic>Tribolium - embryology</topic><topic>Tribolium - genetics</topic><topic>Tribolium - growth & development</topic><topic>Tribolium - metabolism</topic><topic>Twin of eyeless</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xiaoyun</creatorcontrib><creatorcontrib>Weber, Markus</creatorcontrib><creatorcontrib>ZarinKamar, Nazanin</creatorcontrib><creatorcontrib>Posnien, Nico</creatorcontrib><creatorcontrib>Friedrich, Frank</creatorcontrib><creatorcontrib>Wigand, Barbara</creatorcontrib><creatorcontrib>Beutel, Rolf</creatorcontrib><creatorcontrib>Damen, Wim G.M.</creatorcontrib><creatorcontrib>Bucher, Gregor</creatorcontrib><creatorcontrib>Klingler, Martin</creatorcontrib><creatorcontrib>Friedrich, Markus</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xiaoyun</au><au>Weber, Markus</au><au>ZarinKamar, Nazanin</au><au>Posnien, Nico</au><au>Friedrich, Frank</au><au>Wigand, Barbara</au><au>Beutel, Rolf</au><au>Damen, Wim G.M.</au><au>Bucher, Gregor</au><au>Klingler, Martin</au><au>Friedrich, Markus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probing the Drosophila retinal determination gene network in Tribolium ( II): The Pax6 genes eyeless and twin of eyeless</atitle><jtitle>Developmental biology</jtitle><addtitle>Dev Biol</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>333</volume><issue>1</issue><spage>215</spage><epage>227</epage><pages>215-227</pages><issn>0012-1606</issn><eissn>1095-564X</eissn><abstract>The
Pax6 genes
eyeless (
ey) and
twin of eyeless (
toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in
Drosophila. Most animals possess a singleton
Pax6 ortholog, but the dependence of eye development on
Pax6 is widely conserved. A rare exception is given by the larval eyes of
Drosophila, which develop independently of
ey and
toy. To obtain insight into the origin of differential larval and adult eye regulation, we studied the function of
toy and
ey in the red flour beetle
Tribolium castaneum. We find that single and combinatorial knockdown of
toy and
ey affect larval eye development strongly but adult eye development only mildly in this primitive hemimetabolous species. Compound eye-loss, however, was provoked when
ey and
toy were RNAi-silenced in combination with the early retinal gene
dachshund (
dac). We propose that these data reflect a role of
Pax6 during regional specification in the developing head and that the subsequent maintenance and growth of the adult eye primordium is regulated partly by redundant and partly by specific functions of
toy,
ey and
dac in
Tribolium. The results from embryonic knockdown and comparative protein sequence analysis lead us further to conclude that
Tribolium represents an ancestral state of redundant control by
ey and
toy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19527703</pmid><doi>10.1016/j.ydbio.2009.06.013</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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ispartof | Developmental biology, 2009-09, Vol.333 (1), p.215-227 |
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language | eng |
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source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
subjects | Amino Acid Sequence Animals Compound Eye, Arthropod - embryology Compound Eye, Arthropod - growth & development Compound Eye, Arthropod - metabolism Conserved Sequence Dachshund DNA-Binding Proteins - genetics Drosophila Drosophila - genetics Drosophila Proteins - genetics Evolution of development Eye development Eye Proteins - genetics Eyeless Gene Knockdown Techniques Gene Regulatory Networks Homeodomain Proteins - genetics Insect Proteins - biosynthesis Insect Proteins - genetics Molecular Sequence Data Paired Box Transcription Factors - genetics PAX6 Transcription Factor Redundancy Repressor Proteins - genetics Retinal determination gene network Trans-Activators - genetics Tribolium Tribolium - embryology Tribolium - genetics Tribolium - growth & development Tribolium - metabolism Twin of eyeless |
title | Probing the Drosophila retinal determination gene network in Tribolium ( II): The Pax6 genes eyeless and twin of eyeless |
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