Facilitated column selection in pharmaceutical analyses using a simple column classification system

In this paper, the performance of a previously developed classification system applied to pharmaceutical chromatographic analyses, is investigated. The separation of seven different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid,...

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Veröffentlicht in:Journal of Chromatography A 2006-01, Vol.1101 (1), p.103-114
Hauptverfasser: Visky, Dóra, Haghedooren, Erik, Dehouck, Pieter, Kovács, Zsuzsanna, Kóczián, Kristof, Noszál, Béla, Hoogmartens, Jos, Adams, Erwin
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container_end_page 114
container_issue 1
container_start_page 103
container_title Journal of Chromatography A
container_volume 1101
creator Visky, Dóra
Haghedooren, Erik
Dehouck, Pieter
Kovács, Zsuzsanna
Kóczián, Kristof
Noszál, Béla
Hoogmartens, Jos
Adams, Erwin
description In this paper, the performance of a previously developed classification system applied to pharmaceutical chromatographic analyses, is investigated. The separation of seven different drug substances from their respective impurities was studied. The chromatographic procedure for acetylsalicylic acid, clindamycin hydrochloride, buflomedil hydrochloride, chloramphenicol sodium succinate, nimesulide and phenoxymethylpenicillin was performed according to the corresponding European Pharmacopoeia (Ph. Eur.) monograph. The separation of dihydrostreptomycin sulphate was performed according to the literature. It is shown that the column ranking system is a helpful tool in the selection of a suitable column in these analyses.
doi_str_mv 10.1016/j.chroma.2005.09.069
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subjects Analysis
Analytical chemistry
Aspirin - isolation & purification
Biological and medical sciences
Chemistry
Chloramphenicol - analogs & derivatives
Chloramphenicol - isolation & purification
Chromatographic methods and physical methods associated with chromatography
Chromatographic tests
Chromatography, Liquid - instrumentation
Chromatography, Liquid - methods
Clindamycin - isolation & purification
Column characterisation
Column classification
Dihydrostreptomycin Sulfate - isolation & purification
Exact sciences and technology
General pharmacology
Medical sciences
Other chromatographic methods
Penicillin V - isolation & purification
Pharmaceutical Preparations - isolation & purification
Pharmacology. Drug treatments
Pyrrolidines - isolation & purification
Sensitivity and Specificity
Sulfonamides - isolation & purification
title Facilitated column selection in pharmaceutical analyses using a simple column classification system
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