Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus
The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and α-MSH/cocaine and amphetamine-regulated transcript. Because t...
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| creator | Fekete, Csaba Singru, Praful S Sanchez, Edith Sarkar, Sumit Christoffolete, Marcelo A Riberio, Rogerio S Rand, William M Emerson, Charles H Bianco, Antonio C Lechan, Ronald M |
| description | The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and α-MSH/cocaine and amphetamine-regulated transcript. Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 μg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting. |
| doi_str_mv | 10.1210/en.2005-0956 |
| format | Article |
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Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 μg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2005-0956</identifier><identifier>PMID: 16210367</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Agouti Signaling Protein ; Agouti-related protein ; Amphetamines ; Animals ; Arcuate nucleus ; Arcuate Nucleus of Hypothalamus - drug effects ; Arcuate Nucleus of Hypothalamus - physiology ; Biological and medical sciences ; Cerebrospinal fluid ; Circulation ; Cocaine ; Cocaine - pharmacology ; Cocaine- and amphetamine-regulated transcript protein ; Fasting ; Fasting - physiology ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose - administration & dosage ; Glucose - pharmacology ; Homeostasis ; Hypothalamic-pituitary-thyroid axis ; Hypothalamo-Hypophyseal System - drug effects ; Hypothalamo-Hypophyseal System - physiology ; Hypothalamus ; Insulin ; Insulin - administration & dosage ; Insulin - pharmacology ; Intercellular Signaling Peptides and Proteins - genetics ; Leptin ; Leptin - administration & dosage ; Leptin - pharmacology ; Male ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Neuropeptide Y ; Neuropeptide Y - genetics ; Paraventricular nucleus ; Pituitary ; Proopiomelanocortin ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - genetics ; Thyroid ; Thyroid gland ; Thyroid Gland - drug effects ; Thyroid Gland - physiology ; Thyrotropin - genetics ; Thyrotropin-releasing hormone ; Transcription, Genetic - drug effects ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2006-01, Vol.147 (1), p.520-529</ispartof><rights>Copyright © 2006 by The Endocrine Society 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006 by The Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-c857588ec6650ada6d3c3760aac608facd043877f633200373e1a17145b3a03e3</citedby><cites>FETCH-LOGICAL-c558t-c857588ec6650ada6d3c3760aac608facd043877f633200373e1a17145b3a03e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17380200$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16210367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fekete, Csaba</creatorcontrib><creatorcontrib>Singru, Praful S</creatorcontrib><creatorcontrib>Sanchez, Edith</creatorcontrib><creatorcontrib>Sarkar, Sumit</creatorcontrib><creatorcontrib>Christoffolete, Marcelo A</creatorcontrib><creatorcontrib>Riberio, Rogerio S</creatorcontrib><creatorcontrib>Rand, William M</creatorcontrib><creatorcontrib>Emerson, Charles H</creatorcontrib><creatorcontrib>Bianco, Antonio C</creatorcontrib><creatorcontrib>Lechan, Ronald M</creatorcontrib><title>Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and α-MSH/cocaine and amphetamine-regulated transcript. Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 μg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting.</description><subject>Agouti Signaling Protein</subject><subject>Agouti-related protein</subject><subject>Amphetamines</subject><subject>Animals</subject><subject>Arcuate nucleus</subject><subject>Arcuate Nucleus of Hypothalamus - drug effects</subject><subject>Arcuate Nucleus of Hypothalamus - physiology</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Circulation</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Cocaine- and amphetamine-regulated transcript protein</subject><subject>Fasting</subject><subject>Fasting - physiology</subject><subject>Feeding Behavior - drug effects</subject><subject>Feeding Behavior - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - pharmacology</subject><subject>Homeostasis</subject><subject>Hypothalamic-pituitary-thyroid axis</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Hypothalamus</subject><subject>Insulin</subject><subject>Insulin - administration & dosage</subject><subject>Insulin - pharmacology</subject><subject>Intercellular Signaling Peptides and Proteins - genetics</subject><subject>Leptin</subject><subject>Leptin - administration & dosage</subject><subject>Leptin - pharmacology</subject><subject>Male</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Neuropeptide Y</subject><subject>Neuropeptide Y - genetics</subject><subject>Paraventricular nucleus</subject><subject>Pituitary</subject><subject>Proopiomelanocortin</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - genetics</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>Thyrotropin - genetics</subject><subject>Thyrotropin-releasing hormone</subject><subject>Transcription, Genetic - drug effects</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EoiFw44wsIcqlW-x4bW-OUdq0laKCUDmvXHuWuNrYiz8k8sv4e3iVlSIhEKcZv3pmxjMvQm8puaQLSj6Bu1wQwiuy5OIZmtFlzStJJXmOZoRQVsnFQp6hVzE-lWdd1-wlOqOiVDIhZ-jXle06COCSVT2-LrlOEfsOr4sUirSFIVl3ge9czP2Y-IBv-qx9BLwye-tsLFyy3mGTg3Xf8UbFNMaipB3g28Pg0071am919cWmbJMKh-phdwjeGrz6aSNWzuANgCll1VfoVQKD7yEH7yK2xzaroHPR8X3WPeT4Gr3oVB_hzRTn6Nvm-mF9W20_39ytV9tKc96kSjdc8qYBLQQnyihhmGZSEKW0IE2ntCE1a6TsBGPlikwyoIpKWvNHpggDNkfnx75D8D8yxNTubdTQ98qBz7EVksuGUflfkMqakWUtCvj-D_DJ5-DKEi2jjPCG1qwu1MWR0sHHGKBrh2D35XAtJe3oewuuHX1vR98L_m5qmh_3YE7wZHQBPkyAilr1XVBO23jiJGvIeIA5-njkfB7-NbKaRrIjCc54XZyHIUCMp23--tHfX6XTuA</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Fekete, Csaba</creator><creator>Singru, Praful S</creator><creator>Sanchez, Edith</creator><creator>Sarkar, Sumit</creator><creator>Christoffolete, Marcelo A</creator><creator>Riberio, Rogerio S</creator><creator>Rand, William M</creator><creator>Emerson, Charles H</creator><creator>Bianco, Antonio C</creator><creator>Lechan, Ronald M</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus</title><author>Fekete, Csaba ; Singru, Praful S ; Sanchez, Edith ; Sarkar, Sumit ; Christoffolete, Marcelo A ; Riberio, Rogerio S ; Rand, William M ; Emerson, Charles H ; Bianco, Antonio C ; Lechan, Ronald M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-c857588ec6650ada6d3c3760aac608facd043877f633200373e1a17145b3a03e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Agouti Signaling Protein</topic><topic>Agouti-related protein</topic><topic>Amphetamines</topic><topic>Animals</topic><topic>Arcuate nucleus</topic><topic>Arcuate Nucleus of Hypothalamus - drug effects</topic><topic>Arcuate Nucleus of Hypothalamus - physiology</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Circulation</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Cocaine- and amphetamine-regulated transcript protein</topic><topic>Fasting</topic><topic>Fasting - physiology</topic><topic>Feeding Behavior - drug effects</topic><topic>Feeding Behavior - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - pharmacology</topic><topic>Homeostasis</topic><topic>Hypothalamic-pituitary-thyroid axis</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Hypothalamus</topic><topic>Insulin</topic><topic>Insulin - administration & dosage</topic><topic>Insulin - pharmacology</topic><topic>Intercellular Signaling Peptides and Proteins - genetics</topic><topic>Leptin</topic><topic>Leptin - administration & dosage</topic><topic>Leptin - pharmacology</topic><topic>Male</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Neuropeptide Y</topic><topic>Neuropeptide Y - genetics</topic><topic>Paraventricular nucleus</topic><topic>Pituitary</topic><topic>Proopiomelanocortin</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - genetics</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>Thyrotropin - genetics</topic><topic>Thyrotropin-releasing hormone</topic><topic>Transcription, Genetic - drug effects</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fekete, Csaba</creatorcontrib><creatorcontrib>Singru, Praful S</creatorcontrib><creatorcontrib>Sanchez, Edith</creatorcontrib><creatorcontrib>Sarkar, Sumit</creatorcontrib><creatorcontrib>Christoffolete, Marcelo A</creatorcontrib><creatorcontrib>Riberio, Rogerio S</creatorcontrib><creatorcontrib>Rand, William M</creatorcontrib><creatorcontrib>Emerson, Charles H</creatorcontrib><creatorcontrib>Bianco, Antonio C</creatorcontrib><creatorcontrib>Lechan, Ronald M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fekete, Csaba</au><au>Singru, Praful S</au><au>Sanchez, Edith</au><au>Sarkar, Sumit</au><au>Christoffolete, Marcelo A</au><au>Riberio, Rogerio S</au><au>Rand, William M</au><au>Emerson, Charles H</au><au>Bianco, Antonio C</au><au>Lechan, Ronald M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2006-01</date><risdate>2006</risdate><volume>147</volume><issue>1</issue><spage>520</spage><epage>529</epage><pages>520-529</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and α-MSH/cocaine and amphetamine-regulated transcript. Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 μg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>16210367</pmid><doi>10.1210/en.2005-0956</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Agouti Signaling Protein Agouti-related protein Amphetamines Animals Arcuate nucleus Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - physiology Biological and medical sciences Cerebrospinal fluid Circulation Cocaine Cocaine - pharmacology Cocaine- and amphetamine-regulated transcript protein Fasting Fasting - physiology Feeding Behavior - drug effects Feeding Behavior - physiology Fundamental and applied biological sciences. Psychology Glucose Glucose - administration & dosage Glucose - pharmacology Homeostasis Hypothalamic-pituitary-thyroid axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Hypothalamus Insulin Insulin - administration & dosage Insulin - pharmacology Intercellular Signaling Peptides and Proteins - genetics Leptin Leptin - administration & dosage Leptin - pharmacology Male Neurons Neurons - drug effects Neurons - physiology Neuropeptide Y Neuropeptide Y - genetics Paraventricular nucleus Pituitary Proopiomelanocortin Rats Rats, Sprague-Dawley RNA, Messenger - genetics Thyroid Thyroid gland Thyroid Gland - drug effects Thyroid Gland - physiology Thyrotropin - genetics Thyrotropin-releasing hormone Transcription, Genetic - drug effects Vertebrates: endocrinology |
| title | Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus |
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