Fertilization regulates apoptosis of Ciona intestinalis extra-embryonic cells through thyroxine (T4)-dependent NF-kappaB pathway activation during early embryonic development

In Ciona intestinalis, the elimination of extra-embryonic test cells during early stage of development is delayed by a fertilization signal. Test cells undergo a caspase-dependent apoptosis event repressed by thyroxine (T4)-activated NF-kappaB. When apoptosis was experimentally blocked, the hatching...

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Veröffentlicht in:	Developmental biology 2006-01, Vol.289 (1), p.152-165
Hauptverfasser:	Maury, Benoît, Martinand-Mari, Camille, Chambon, Jean-Philippe, Soulé, Jonathan, Degols, Geneviève, Sahuquet, Alain, Weill, Mylène, Berthomieu, Arnaud, Fort, Philippe, Mangeat, Paul, Baghdiguian, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Apoptosis - drug effects Apoptosis - genetics Caspase Inhibitors Caspases - metabolism Cell Extracts - pharmacology Cell Nucleus - chemistry Ciona intestinalis - cytology Ciona intestinalis - embryology Ciona intestinalis - genetics Dexamethasone - pharmacology Embryonic Development Fertilization Gene Expression Molecular Sequence Data NF-kappa B - analysis NF-kappa B - genetics NF-kappa B - metabolism Ovum - drug effects Ovum - metabolism Signal Transduction Thyroxine - metabolism Thyroxine - pharmacology Zygote - chemistry Zygote - cytology Zygote - metabolism
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