An in vivo and in vitro comparison of CYP gene induction in mice using liver slices and quantitative RT-PCR

The scope of this study was to compare in vitro and in vivo cytochrome P450 (CYP) gene induction in mice, using liver slices as an in vitro model. We have chosen to study mice to be able to better interpret CYP induction during long-term safety studies in this species. Mouse liver slices were incuba...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology in vitro 2006-02, Vol.20 (1), p.125-131
Hauptverfasser:	Martignoni, Marcella, de Kanter, Ruben, Grossi, Pietro, Saturno, Grazia, Barbaria, Elena, Monshouwer, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Naphthoflavone - pharmacology Biological Assay CYP induction Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Dexamethasone - pharmacology Gene Expression Regulation, Enzymologic - drug effects In vitro In Vitro Techniques Liver Liver - enzymology Male Methods Mice Mice, Inbred Strains Mouse Phenobarbital - pharmacology RNA, Messenger - metabolism Slices Transcriptional Activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!