An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer
The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a replicating adenovirus, Ad[I/PPT-E1A], where E1A gene expression is controlled by a recombinant regulatory sequence designated PPT. The PPT sequen...
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| Veröffentlicht in: | Cancer gene therapy 2006-01, Vol.13 (1), p.13-20 |
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| creator | Cheng, W-S Dzojic, H Nilsson, B Tötterman, T H Essand, M |
| description | The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a replicating adenovirus, Ad[I/PPT-E1A], where E1A gene expression is controlled by a recombinant regulatory sequence designated PPT. The PPT sequence comprises a PSA enhancer, a PSMA enhancer and a T-cell receptor
γ
-chain alternate reading frame protein promoter, and it is shielded from transcriptional interference from adenoviral backbone sequences by an H19 insulator. Ad[I/PPT-E1A] yields prostate-specific E1A protein expression, viral replication and cytolysis
in vitro
. Furthermore, Ad[I/PPT-E1A] considerably regresses the growth of subcutaneous LNCaP prostate cancer tumors in nude mice. Importantly, the viral replication and cytolytic effect of Ad[I/PPT-E1A] are independent of the testosterone levels in the prostate cancer cells. This may be beneficial in a clinical setting since many prostate cancer patients are treated with androgen withdrawal. In conclusion, Ad[I/PPT-E1A] may prove to be useful in the treatment of localized prostate cancer. |
| doi_str_mv | 10.1038/sj.cgt.7700881 |
| format | Article |
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γ
-chain alternate reading frame protein promoter, and it is shielded from transcriptional interference from adenoviral backbone sequences by an H19 insulator. Ad[I/PPT-E1A] yields prostate-specific E1A protein expression, viral replication and cytolysis
in vitro
. Furthermore, Ad[I/PPT-E1A] considerably regresses the growth of subcutaneous LNCaP prostate cancer tumors in nude mice. Importantly, the viral replication and cytolytic effect of Ad[I/PPT-E1A] are independent of the testosterone levels in the prostate cancer cells. This may be beneficial in a clinical setting since many prostate cancer patients are treated with androgen withdrawal. In conclusion, Ad[I/PPT-E1A] may prove to be useful in the treatment of localized prostate cancer.</description><identifier>ISSN: 0929-1903</identifier><identifier>EISSN: 1476-5500</identifier><identifier>DOI: 10.1038/sj.cgt.7700881</identifier><identifier>PMID: 16052227</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adenoviridae - metabolism ; Adenovirus ; Adenovirus E1A Proteins - genetics ; Adenovirus E1A Proteins - metabolism ; Adenoviruses ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Care and treatment ; Gene Expression ; Gene Expression Regulation, Neoplastic ; Gene Therapy ; Genetic aspects ; Genetic Vectors - metabolism ; Genetic Vectors - therapeutic use ; Health aspects ; Humans ; Male ; Methods ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Neoplasms, Hormone-Dependent - genetics ; Neoplasms, Hormone-Dependent - metabolism ; original-article ; Physiological aspects ; Prostate cancer ; Prostatic Neoplasms - metabolism ; Testosterone - metabolism ; Time Factors ; Transfection ; Virus Replication</subject><ispartof>Cancer gene therapy, 2006-01, Vol.13 (1), p.13-20</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-17788191ceee293d250d66f2e115c8cfbf621abedc1454099ab1614e9e77a4173</citedby><cites>FETCH-LOGICAL-c489t-17788191ceee293d250d66f2e115c8cfbf621abedc1454099ab1614e9e77a4173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.cgt.7700881$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.cgt.7700881$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16052227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, W-S</creatorcontrib><creatorcontrib>Dzojic, H</creatorcontrib><creatorcontrib>Nilsson, B</creatorcontrib><creatorcontrib>Tötterman, T H</creatorcontrib><creatorcontrib>Essand, M</creatorcontrib><title>An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer</title><title>Cancer gene therapy</title><addtitle>Cancer Gene Ther</addtitle><addtitle>Cancer Gene Ther</addtitle><description>The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a replicating adenovirus, Ad[I/PPT-E1A], where E1A gene expression is controlled by a recombinant regulatory sequence designated PPT. The PPT sequence comprises a PSA enhancer, a PSMA enhancer and a T-cell receptor
γ
-chain alternate reading frame protein promoter, and it is shielded from transcriptional interference from adenoviral backbone sequences by an H19 insulator. Ad[I/PPT-E1A] yields prostate-specific E1A protein expression, viral replication and cytolysis
in vitro
. Furthermore, Ad[I/PPT-E1A] considerably regresses the growth of subcutaneous LNCaP prostate cancer tumors in nude mice. Importantly, the viral replication and cytolytic effect of Ad[I/PPT-E1A] are independent of the testosterone levels in the prostate cancer cells. This may be beneficial in a clinical setting since many prostate cancer patients are treated with androgen withdrawal. In conclusion, Ad[I/PPT-E1A] may prove to be useful in the treatment of localized prostate cancer.</description><subject>Adenoviridae - metabolism</subject><subject>Adenovirus</subject><subject>Adenovirus E1A Proteins - genetics</subject><subject>Adenovirus E1A Proteins - metabolism</subject><subject>Adenoviruses</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Care and treatment</subject><subject>Gene Expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Therapy</subject><subject>Genetic aspects</subject><subject>Genetic Vectors - metabolism</subject><subject>Genetic Vectors - therapeutic use</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Nude</subject><subject>Neoplasms, Hormone-Dependent - genetics</subject><subject>Neoplasms, Hormone-Dependent - metabolism</subject><subject>original-article</subject><subject>Physiological aspects</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Testosterone - metabolism</subject><subject>Time Factors</subject><subject>Transfection</subject><subject>Virus Replication</subject><issn>0929-1903</issn><issn>1476-5500</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFks2rEzEUxYMovlrdupRB4e2mLzfzkcmyPPyCB250HdLkTpuSSWqSEfrfm9JiVZ5IFoF7f_eEe3IIeQ10BbQZ7tJ-pbd5xTmlwwBPyAJa3tddR-lTsqCCiRoEbW7Ii5T2lJYmb56TG-hpxxjjCxLWvgpeB3fMVlc6eGOzDV45d6wiHpzVKlu_rZRBH37YOKdqDLHahTgFj7XBA_rSypXy5lfV-mv9EEPKKmOlldcYX5Jno3IJX13uJfn24f3X-0_1w5ePn-_XD7VuB5Fr4LysI0AjIhONYR01fT8yBOj0oMfN2DNQGzQa2q6lQqgN9NCiQM5VC7xZktuzbnn_-4wpy8kmjc4pj2FOsucdbylr_guCKJYNoivg27_AfZhjcSpJBrwtVsNQoHdnaKscSuvHkKPSJ0W5hoH1HT3JLcnqEaocg5Mtf4CjLfU_Bm5_G9ihcnmXgptPX5UeVdbF9hRxlIdoJxWPEqg8BUamvSyBkZfAlIE3l63mzYTmil8SUoC7M5BKy28xXtf-h-RP9mTL6A</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Cheng, W-S</creator><creator>Dzojic, H</creator><creator>Nilsson, B</creator><creator>Tötterman, T H</creator><creator>Essand, M</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20060101</creationdate><title>An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer</title><author>Cheng, W-S ; Dzojic, H ; Nilsson, B ; Tötterman, T H ; Essand, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-17788191ceee293d250d66f2e115c8cfbf621abedc1454099ab1614e9e77a4173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenoviridae - metabolism</topic><topic>Adenovirus</topic><topic>Adenovirus E1A Proteins - genetics</topic><topic>Adenovirus E1A Proteins - metabolism</topic><topic>Adenoviruses</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Care and treatment</topic><topic>Gene Expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Therapy</topic><topic>Genetic aspects</topic><topic>Genetic Vectors - metabolism</topic><topic>Genetic Vectors - therapeutic use</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Methods</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Nude</topic><topic>Neoplasms, Hormone-Dependent - genetics</topic><topic>Neoplasms, Hormone-Dependent - metabolism</topic><topic>original-article</topic><topic>Physiological aspects</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Testosterone - metabolism</topic><topic>Time Factors</topic><topic>Transfection</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, W-S</creatorcontrib><creatorcontrib>Dzojic, H</creatorcontrib><creatorcontrib>Nilsson, B</creatorcontrib><creatorcontrib>Tötterman, T H</creatorcontrib><creatorcontrib>Essand, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer gene therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, W-S</au><au>Dzojic, H</au><au>Nilsson, B</au><au>Tötterman, T H</au><au>Essand, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer</atitle><jtitle>Cancer gene therapy</jtitle><stitle>Cancer Gene Ther</stitle><addtitle>Cancer Gene Ther</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>13</volume><issue>1</issue><spage>13</spage><epage>20</epage><pages>13-20</pages><issn>0929-1903</issn><eissn>1476-5500</eissn><abstract>The use of conditionally replicating adenoviruses offers an attractive complementary treatment strategy for localized prostate cancer. We have produced a replicating adenovirus, Ad[I/PPT-E1A], where E1A gene expression is controlled by a recombinant regulatory sequence designated PPT. The PPT sequence comprises a PSA enhancer, a PSMA enhancer and a T-cell receptor
γ
-chain alternate reading frame protein promoter, and it is shielded from transcriptional interference from adenoviral backbone sequences by an H19 insulator. Ad[I/PPT-E1A] yields prostate-specific E1A protein expression, viral replication and cytolysis
in vitro
. Furthermore, Ad[I/PPT-E1A] considerably regresses the growth of subcutaneous LNCaP prostate cancer tumors in nude mice. Importantly, the viral replication and cytolytic effect of Ad[I/PPT-E1A] are independent of the testosterone levels in the prostate cancer cells. This may be beneficial in a clinical setting since many prostate cancer patients are treated with androgen withdrawal. In conclusion, Ad[I/PPT-E1A] may prove to be useful in the treatment of localized prostate cancer.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16052227</pmid><doi>10.1038/sj.cgt.7700881</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenoviridae - metabolism Adenovirus Adenovirus E1A Proteins - genetics Adenovirus E1A Proteins - metabolism Adenoviruses Animals Biomedical and Life Sciences Biomedicine Care and treatment Gene Expression Gene Expression Regulation, Neoplastic Gene Therapy Genetic aspects Genetic Vectors - metabolism Genetic Vectors - therapeutic use Health aspects Humans Male Methods Mice Mice, Inbred C57BL Mice, Nude Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism original-article Physiological aspects Prostate cancer Prostatic Neoplasms - metabolism Testosterone - metabolism Time Factors Transfection Virus Replication |
| title | An oncolytic conditionally replicating adenovirus for hormone-dependent and hormone-independent prostate cancer |
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