Cannabinoid signalling
After their discovery, the two known cannabinoid receptors, CB 1 and CB 2, have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G i/o proteins, negatively modulate cyclic AM...
Gespeichert in:
| Veröffentlicht in: | Life sciences (1973) 2006-01, Vol.78 (6), p.549-563 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 563 |
|---|---|
| container_issue | 6 |
| container_start_page | 549 |
| container_title | Life sciences (1973) |
| container_volume | 78 |
| creator | Demuth, Dirk G. Molleman, Areles |
| description | After their discovery, the two known cannabinoid receptors, CB
1 and CB
2, have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G
i/o proteins, negatively modulate cyclic AMP levels, and activate inward rectifying K
+ channels. Recent findings have complicated this assessment on different levels: (1) cannabinoids include a wide range of compounds with varying profiles of affinity and efficacy at the known CB receptors, and these profiles do not necessarily match their biological activity; (2) CB receptors appear to be intrinsically active and possibly coupled to more than one type of G protein; (3) CB receptor signalling mechanisms are diverse and dependent on the system studied; (4) cannabinoids have other targets than CB receptors. The aim of this mini review is to discuss the current literature regarding CB receptor signalling pathways. These include regulation of adenylyl cyclase, MAP kinase, intracellular Ca
2+, and ion channels. In addition, actions of cannabinoids that are not mediated by CB
1 or CB
2 receptors are discussed. |
| doi_str_mv | 10.1016/j.lfs.2005.05.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67573893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0024320505006727</els_id><sourcerecordid>67573893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-1a88a27ea99df1b2aa22cecdb29766a9cc9012c8c3105b60cef6d96c37a1450e3</originalsourceid><addsrcrecordid>eNp9kM1LAzEQxYMotlavghfx5G3XmaTJbvAkxS8oeNFzyCazJWWb1U0r-N-bfoA34cFcfu8x7zF2hVAioLpbll2bSg4gy53kERtjXekClMBjNgbg00JwkCN2ltISMigrccpGqBD0VMCYXc5sjLYJsQ_-JoVFtF0X4uKcnbS2S3RxuBP28fT4Pnsp5m_Pr7OHeeGExHWBtq4tr8hq7VtsuLWcO3K-4bpSymrnNCB3tRMIslHgqFVeKycqi1MJJCbsdp_7OfRfG0prswrJUdfZSP0mGVXlh2stMoh70A19SgO15nMIKzv8GASzHcMsTR7DbMcwO8nsuT6Eb5oV-T_HoX0G7vcA5YrfgQaTXKDoyIeB3Nr4PvwT_wv_623x</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67573893</pqid></control><display><type>article</type><title>Cannabinoid signalling</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Demuth, Dirk G. ; Molleman, Areles</creator><creatorcontrib>Demuth, Dirk G. ; Molleman, Areles</creatorcontrib><description>After their discovery, the two known cannabinoid receptors, CB
1 and CB
2, have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G
i/o proteins, negatively modulate cyclic AMP levels, and activate inward rectifying K
+ channels. Recent findings have complicated this assessment on different levels: (1) cannabinoids include a wide range of compounds with varying profiles of affinity and efficacy at the known CB receptors, and these profiles do not necessarily match their biological activity; (2) CB receptors appear to be intrinsically active and possibly coupled to more than one type of G protein; (3) CB receptor signalling mechanisms are diverse and dependent on the system studied; (4) cannabinoids have other targets than CB receptors. The aim of this mini review is to discuss the current literature regarding CB receptor signalling pathways. These include regulation of adenylyl cyclase, MAP kinase, intracellular Ca
2+, and ion channels. In addition, actions of cannabinoids that are not mediated by CB
1 or CB
2 receptors are discussed.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2005.05.055</identifier><identifier>PMID: 16109430</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adenylyl Cyclases - metabolism ; Animals ; Calcium - metabolism ; Cannabinoid receptor ; Cannabinoids ; Cannabinoids - pharmacology ; G proteins ; GTP-Binding Proteins - physiology ; Humans ; Ion channels ; Ion Channels - physiology ; Mitogen-Activated Protein Kinases - metabolism ; Receptor, Cannabinoid, CB1 - physiology ; Receptor, Cannabinoid, CB2 - physiology ; Receptors, N-Methyl-D-Aspartate - drug effects ; Receptors, Opioid - drug effects ; Receptors, Serotonin, 5-HT3 - drug effects ; Second messengers ; Signal transduction ; Signal Transduction - physiology ; TRPV Cation Channels - drug effects</subject><ispartof>Life sciences (1973), 2006-01, Vol.78 (6), p.549-563</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-1a88a27ea99df1b2aa22cecdb29766a9cc9012c8c3105b60cef6d96c37a1450e3</citedby><cites>FETCH-LOGICAL-c351t-1a88a27ea99df1b2aa22cecdb29766a9cc9012c8c3105b60cef6d96c37a1450e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2005.05.055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16109430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demuth, Dirk G.</creatorcontrib><creatorcontrib>Molleman, Areles</creatorcontrib><title>Cannabinoid signalling</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>After their discovery, the two known cannabinoid receptors, CB
1 and CB
2, have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G
i/o proteins, negatively modulate cyclic AMP levels, and activate inward rectifying K
+ channels. Recent findings have complicated this assessment on different levels: (1) cannabinoids include a wide range of compounds with varying profiles of affinity and efficacy at the known CB receptors, and these profiles do not necessarily match their biological activity; (2) CB receptors appear to be intrinsically active and possibly coupled to more than one type of G protein; (3) CB receptor signalling mechanisms are diverse and dependent on the system studied; (4) cannabinoids have other targets than CB receptors. The aim of this mini review is to discuss the current literature regarding CB receptor signalling pathways. These include regulation of adenylyl cyclase, MAP kinase, intracellular Ca
2+, and ion channels. In addition, actions of cannabinoids that are not mediated by CB
1 or CB
2 receptors are discussed.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Cannabinoid receptor</subject><subject>Cannabinoids</subject><subject>Cannabinoids - pharmacology</subject><subject>G proteins</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Humans</subject><subject>Ion channels</subject><subject>Ion Channels - physiology</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Receptor, Cannabinoid, CB1 - physiology</subject><subject>Receptor, Cannabinoid, CB2 - physiology</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Receptors, Opioid - drug effects</subject><subject>Receptors, Serotonin, 5-HT3 - drug effects</subject><subject>Second messengers</subject><subject>Signal transduction</subject><subject>Signal Transduction - physiology</subject><subject>TRPV Cation Channels - drug effects</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMotlavghfx5G3XmaTJbvAkxS8oeNFzyCazJWWb1U0r-N-bfoA34cFcfu8x7zF2hVAioLpbll2bSg4gy53kERtjXekClMBjNgbg00JwkCN2ltISMigrccpGqBD0VMCYXc5sjLYJsQ_-JoVFtF0X4uKcnbS2S3RxuBP28fT4Pnsp5m_Pr7OHeeGExHWBtq4tr8hq7VtsuLWcO3K-4bpSymrnNCB3tRMIslHgqFVeKycqi1MJJCbsdp_7OfRfG0prswrJUdfZSP0mGVXlh2stMoh70A19SgO15nMIKzv8GASzHcMsTR7DbMcwO8nsuT6Eb5oV-T_HoX0G7vcA5YrfgQaTXKDoyIeB3Nr4PvwT_wv_623x</recordid><startdate>20060102</startdate><enddate>20060102</enddate><creator>Demuth, Dirk G.</creator><creator>Molleman, Areles</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060102</creationdate><title>Cannabinoid signalling</title><author>Demuth, Dirk G. ; Molleman, Areles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-1a88a27ea99df1b2aa22cecdb29766a9cc9012c8c3105b60cef6d96c37a1450e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Cannabinoid receptor</topic><topic>Cannabinoids</topic><topic>Cannabinoids - pharmacology</topic><topic>G proteins</topic><topic>GTP-Binding Proteins - physiology</topic><topic>Humans</topic><topic>Ion channels</topic><topic>Ion Channels - physiology</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Receptor, Cannabinoid, CB1 - physiology</topic><topic>Receptor, Cannabinoid, CB2 - physiology</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Receptors, Opioid - drug effects</topic><topic>Receptors, Serotonin, 5-HT3 - drug effects</topic><topic>Second messengers</topic><topic>Signal transduction</topic><topic>Signal Transduction - physiology</topic><topic>TRPV Cation Channels - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demuth, Dirk G.</creatorcontrib><creatorcontrib>Molleman, Areles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demuth, Dirk G.</au><au>Molleman, Areles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cannabinoid signalling</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2006-01-02</date><risdate>2006</risdate><volume>78</volume><issue>6</issue><spage>549</spage><epage>563</epage><pages>549-563</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>After their discovery, the two known cannabinoid receptors, CB
1 and CB
2, have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G
i/o proteins, negatively modulate cyclic AMP levels, and activate inward rectifying K
+ channels. Recent findings have complicated this assessment on different levels: (1) cannabinoids include a wide range of compounds with varying profiles of affinity and efficacy at the known CB receptors, and these profiles do not necessarily match their biological activity; (2) CB receptors appear to be intrinsically active and possibly coupled to more than one type of G protein; (3) CB receptor signalling mechanisms are diverse and dependent on the system studied; (4) cannabinoids have other targets than CB receptors. The aim of this mini review is to discuss the current literature regarding CB receptor signalling pathways. These include regulation of adenylyl cyclase, MAP kinase, intracellular Ca
2+, and ion channels. In addition, actions of cannabinoids that are not mediated by CB
1 or CB
2 receptors are discussed.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>16109430</pmid><doi>10.1016/j.lfs.2005.05.055</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2006-01, Vol.78 (6), p.549-563 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67573893 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenylyl Cyclases - metabolism Animals Calcium - metabolism Cannabinoid receptor Cannabinoids Cannabinoids - pharmacology G proteins GTP-Binding Proteins - physiology Humans Ion channels Ion Channels - physiology Mitogen-Activated Protein Kinases - metabolism Receptor, Cannabinoid, CB1 - physiology Receptor, Cannabinoid, CB2 - physiology Receptors, N-Methyl-D-Aspartate - drug effects Receptors, Opioid - drug effects Receptors, Serotonin, 5-HT3 - drug effects Second messengers Signal transduction Signal Transduction - physiology TRPV Cation Channels - drug effects |
| title | Cannabinoid signalling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T03%3A32%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cannabinoid%20signalling&rft.jtitle=Life%20sciences%20(1973)&rft.au=Demuth,%20Dirk%20G.&rft.date=2006-01-02&rft.volume=78&rft.issue=6&rft.spage=549&rft.epage=563&rft.pages=549-563&rft.issn=0024-3205&rft.eissn=1879-0631&rft_id=info:doi/10.1016/j.lfs.2005.05.055&rft_dat=%3Cproquest_cross%3E67573893%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67573893&rft_id=info:pmid/16109430&rft_els_id=S0024320505006727&rfr_iscdi=true |