Effect of Adeno-Associated Virus Serotype and Genomic Structure on Liver Transduction and Biodistribution in Mice of Both Genders

Recombinant adeno-associated viral (AAV) vectors have unique properties, which make them suitable vectors for gene transfer. Here we assess the liver transduction efficiency and biodistribution of AAV-pseudotyped capsids (serotypes) 1, 5, 6, and 8, combined with single-stranded and double-stranded g...

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Veröffentlicht in:	Human gene therapy 2009-08, Vol.20 (8), p.908-917
Hauptverfasser:	PANEDA, Astrid, VANRELL, Lucia, FONTANELLAS, Antonio, SOL RODRIGUEZ-PENA, Maria, GONZALEZ-ASEGUINOLAZA, Gloria, MAULEON, Itsaso, CRETTAZ, Julien S, BERRAONDO, Pedro, TIMMERMANS, Eric J, BEATTIE, Stuart G, TWISK, Jaap, VAN DEVENTER, Sander, PRIETO, Jesus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Dependovirus - classification Dependovirus - genetics Diverse techniques Female Fundamental and applied biological sciences. Psychology Gene therapy Genetic aspects Genetic vectors Genome, Viral - genetics Germ Cells - virology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Injections, Intravenous Liver - metabolism Liver - virology Luciferase Luciferases - metabolism Luminescent Measurements Male Medical sciences Mice Mice, Inbred BALB C Molecular and cellular biology Ovary - cytology Ovary - virology Physiological aspects Serotyping Sex Characteristics Time Factors Tissue Distribution Transduction Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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