Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter

To develop a gene therapy that would selectively kill prostate cancer cells while sparing normal cells, we have constructed lentiviral vectors that contain a therapeutic gene with a short DNA sequence in the 5′-untranslated region (UTR) that is recognized by the translation initiation factor, eIF4E,...

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Veröffentlicht in:	Cancer gene therapy 2006-01, Vol.13 (1), p.32-43
Hauptverfasser:	Yu, D, Scott, C, Jia, W W, De Benedetti, A, Williams, B J, Fazli, L, Wen, Y, Gleave, M, Nelson, C, Rennie, P S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Care and treatment Cell Death - drug effects Cytomegalovirus Dose-Response Relationship, Drug Eukaryotic Initiation Factor-4E - metabolism Eukaryotic Initiation Factor-4E - pharmacology Gene Expression Gene Expression Regulation, Neoplastic Gene Therapy Genetic aspects Genetic regulation Genetic Vectors - genetics Genetic Vectors - metabolism Genetic Vectors - pharmacology Health aspects Humans Immunohistochemistry Lentivirus Lentivirus - metabolism Lentivirus - pathogenicity Male Methods Models, Genetic original-article Physiological aspects Promoter Regions, Genetic - physiology Prostate cancer Prostatic Neoplasms - metabolism Thymidine Kinase - metabolism Transfection Tumor Cells, Cultured
Online-Zugang:	Volltext
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