High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity

Rats bred for a high-capacity to run (HCR) do not develop insulin resistance on a high-fat diet (HFD) vs. those bred for a low-capacity for running (LCR). Recently, a link between obesity and insulin resistance has been established via IKKbeta action and IRS-1 Ser (312/307) phosphorylation. This stu...

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Veröffentlicht in:	International journal of sports medicine 2009-09, Vol.30 (9), p.631-635
Hauptverfasser:	Bikman, B T, Woodlief, T L, Noland, R C, Britton, S L, Koch, L G, Lust, R M, Dohm, G L, Cortright, R N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Dietary Fats I-kappa B Kinase - metabolism I-kappa B Proteins - metabolism Insulin - blood Insulin Receptor Substrate Proteins - metabolism Insulin Resistance - physiology Male Muscle, Skeletal - metabolism NF-KappaB Inhibitor alpha Rats Running - physiology
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