Age-related spatial working memory impairment is caused by prefrontal cortical dopaminergic dysfunction in rats

Abstract There is evidence of prefrontal cortex (PFC)–dependent cognitive deficits, such as working memory impairment, during the normal aging process in humans and animals. Although working memory function and the PFC dopaminergic system are thought to be closely related, the relationship between t...

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Veröffentlicht in:	Neuroscience 2009-09, Vol.162 (4), p.1192-1201
Hauptverfasser:	Mizoguchi, K, Shoji, H, Tanaka, Y, Maruyama, W, Tabira, T
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Animals Benzazepines - pharmacology Biological and medical sciences cognitive function D1 receptor dopamine Dopamine - biosynthesis Dopamine - physiology Fundamental and applied biological sciences. Psychology Male Maze Learning - drug effects Memory, Short-Term - physiology Neurology Neurons - physiology prefrontal cortex Prefrontal Cortex - physiology Rats Rats, Inbred F344 Receptors, Dopamine D1 - agonists Receptors, Dopamine D1 - antagonists & inhibitors Spatial Behavior - physiology Synaptic Transmission Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase Vertebrates: nervous system and sense organs
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