Substituted 5,5‘-Diphenyl-2-thioxoimidazolidin-4-one as CB1 Cannabinoid Receptor Ligands: Synthesis and Pharmacological Evaluation

A set of 30 substituted 5,5‘-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB1 cannabinoid receptor has been evaluated. These compounds are derived from the previously described cannabinoid ligands 5,5‘-diphenylimidazolidine-2,4-di...

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Veröffentlicht in:	Journal of medicinal chemistry 2005-04, Vol.48 (7), p.2509-2517
Hauptverfasser:	Muccioli, Giulio G, Martin, Diana, Scriba, Gerhard K. E, Poppitz, Wolfgang, Poupaert, Jacques H, Wouters, Johan, Lambert, Didier M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences CHO Cells Cricetinae Cricetulus Humans Imidazolidines - chemical synthesis Imidazolidines - chemistry Imidazolidines - pharmacology Ligands Medical sciences Miscellaneous Models, Molecular Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Radioligand Assay Receptor, Cannabinoid, CB1 - drug effects Receptor, Cannabinoid, CB1 - metabolism Structure-Activity Relationship Thiohydantoins - chemical synthesis Thiohydantoins - chemistry Thiohydantoins - pharmacology
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