Down regulation of KMP-11 in Leishmania infantum axenic antimony resistant amastigotes as revealed by a proteomic screen

The therapeutic mainstay against the protozoan parasite Leishmania is still based on the antiquated pentavalent antimonials, but resistance is increasing in several parts of the world. Resistance is now partly understood in laboratory promastigote isolates, but the mechanism leading to drug resistan...

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Veröffentlicht in:	Experimental parasitology 2009-09, Vol.123 (1), p.51-57
Hauptverfasser:	El Fadili, Karima, Drummelsmith, Jolyne, Roy, Gaétan, Jardim, Armando, Ouellette, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimony Sodium Gluconate - pharmacology Antiprotozoal Agents - pharmacology Argininosuccinate Synthase - genetics Argininosuccinate Synthase - metabolism Biological and medical sciences Blotting, Northern Blotting, Western Down-Regulation Drug resistance Drug Resistance - physiology Electrophoresis, Gel, Two-Dimensional Fundamental and applied biological sciences. Psychology Gene Expression Leishmania Leishmania infantum Leishmania infantum - drug effects Leishmania infantum - genetics Leishmania infantum - metabolism Life cycle. Host-agent relationship. Pathogenesis Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Open Reading Frames Proteomics Proteomics - methods Protozoa Protozoan Proteins - genetics Protozoan Proteins - metabolism RNA, Protozoan - metabolism
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