Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells. Three clusters, miR-200c-141, miR-200b-200a-429, and miR-183-96-182...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2009-08, Vol.138 (3), p.592-603
Hauptverfasser:	Shimono, Yohei, Zabala, Maider, Cho, Robert W., Lobo, Neethan, Dalerba, Piero, Qian, Dalong, Diehn, Maximilian, Liu, Huiping, Panula, Sarita P., Chiao, Eric, Dirbas, Frederick M., Somlo, George, Pera, Renee A. Reijo, Lao, Kaiqin, Clarke, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast - cytology Breast Neoplasms - genetics Cell Line Cell Line, Tumor Down-Regulation Embryonal Carcinoma Stem Cells - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans HUMDISEASE MicroRNAs - genetics MicroRNAs - metabolism Neoplastic Stem Cells - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Polycomb Repressive Complex 1 Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Stem Cells - metabolism STEMCELL
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!