Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro
Prostate cancer is the most predominant cancer in men and prostate cancer related death increases every year. Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies re...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2005, Vol.28(4), pp.740-743 |
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| container_title | Biological & Pharmaceutical Bulletin |
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| creator | Arunkumar, Arumugam Vijayababu, Marati Radhakrishnan Kanagaraj, Palaniyandi Balasubramanian, Karundevi Aruldhas, Maria Michael Arunakaran, Jagadeesan |
| description | Prostate cancer is the most predominant cancer in men and prostate cancer related death increases every year. Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [3H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50 μM and 100 μM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. It is concluded that diallyl disulfide, component of aged garlic extract, inhibits proliferation of prostate cancer cells through the induction of apoptosis. |
| doi_str_mv | 10.1248/bpb.28.740 |
| format | Article |
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Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [3H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50 μM and 100 μM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. It is concluded that diallyl disulfide, component of aged garlic extract, inhibits proliferation of prostate cancer cells through the induction of apoptosis.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.28.740</identifier><identifier>PMID: 15802821</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Allyl Compounds - pharmacology ; Antineoplastic Agents - pharmacology ; antiproliferation ; apoptosis ; Apoptosis - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; diallyl disulfide ; Disulfides - pharmacology ; DNA Damage - drug effects ; DNA fragmentation ; Dose-Response Relationship, Drug ; Garlic - chemistry ; Humans ; Male ; prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - pathology</subject><ispartof>Biological and Pharmaceutical Bulletin, 2005, Vol.28(4), pp.740-743</ispartof><rights>2005 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c685t-9575ffd93f39f99b7fcfa83ec68cb4b0a9f16ad32263dd8a21282d940c7e7f393</citedby><cites>FETCH-LOGICAL-c685t-9575ffd93f39f99b7fcfa83ec68cb4b0a9f16ad32263dd8a21282d940c7e7f393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15802821$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arunkumar, Arumugam</creatorcontrib><creatorcontrib>Vijayababu, Marati Radhakrishnan</creatorcontrib><creatorcontrib>Kanagaraj, Palaniyandi</creatorcontrib><creatorcontrib>Balasubramanian, Karundevi</creatorcontrib><creatorcontrib>Aruldhas, Maria Michael</creatorcontrib><creatorcontrib>Arunakaran, Jagadeesan</creatorcontrib><creatorcontrib>Dr. ALM PG Institute of Basic Medical Sciences</creatorcontrib><creatorcontrib>Department of Endocrinology</creatorcontrib><creatorcontrib>University of Madras</creatorcontrib><title>Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Prostate cancer is the most predominant cancer in men and prostate cancer related death increases every year. Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [3H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50 μM and 100 μM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. It is concluded that diallyl disulfide, component of aged garlic extract, inhibits proliferation of prostate cancer cells through the induction of apoptosis.</description><subject>Allyl Compounds - pharmacology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antiproliferation</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>diallyl disulfide</subject><subject>Disulfides - pharmacology</subject><subject>DNA Damage - drug effects</subject><subject>DNA fragmentation</subject><subject>Dose-Response Relationship, Drug</subject><subject>Garlic - chemistry</subject><subject>Humans</subject><subject>Male</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - pathology</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVtrFDEUxwdR7Lb64geQgCAqzJrrZOZJZFpXYcGCl9eQySRt1mwyJjNIv71n2a0FX84JOb_zP7eqekHwmlDevh-mYU3bteT4UbUijMtaUCIeVyvckbZuiGjPqvNSdhhjiSl7Wp3BF6YtJavq1yanP_Mt-rZMU7al-HiDrpyzZkbJoY3OwRvUp_2UljiiS69DuAvgyxKcHy1KEV3nVGY9W9TraGxGvQ0BbX206M11X7O3yEf00885PaueOB2KfX7yF9WPT1ff-8_19uvmS_9xW5umFXPdCSmcGzvmWOe6bpDOON0yC1Ez8AHrzpFGj4zSho1jqymBUcaOYyOthBx2Ub0-6k45_V5smdXeFwNd6WjTUlQjhcScCgBf_Qfu0pIj9KYI5x3jhGMJ1LsjZWDQkq1TU_Z7ne8UwepwAAUHULRVcACAX54kl2Fvxwf0tHEANkcAot7okGKAVT0UNkUOPoWkKMZCYUjCXGEGT5A_GEawJFQ0oPThqLSD9d_Yf6V0nr0J9r4rfjSH7PuIudVZ2cj-Akq3rLw</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>Arunkumar, Arumugam</creator><creator>Vijayababu, Marati Radhakrishnan</creator><creator>Kanagaraj, Palaniyandi</creator><creator>Balasubramanian, Karundevi</creator><creator>Aruldhas, Maria Michael</creator><creator>Arunakaran, Jagadeesan</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro</title><author>Arunkumar, Arumugam ; 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Till date, there is no effective therapy other than androgen ablation therapy. At this stage, induction of apoptosis is considered as a better strategy to control cancer. Previous studies reported that aged garlic extract suppresses cancer growth and enhances immune system against cancer. In the present study, diallyl disulfide, oil soluble organosulfur compound of garlic, was studied for its antiproliferative effect on prostate cancer cells in vitro. The suppression of cell growth was demonstrated by [3H]thymidine incorporation assay. Induction of DNA damage was assessed by agarose gel electrophoresis. The results showed that diallyl disulfide inhibited the growth of prostate cancer cells in a dose dependent manner, compared to the control. At 50 μM and 100 μM concentrations, diallyl disulfide induced DNA damage in PC-3 cells. 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| subjects | Allyl Compounds - pharmacology Antineoplastic Agents - pharmacology antiproliferation apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Proliferation - drug effects diallyl disulfide Disulfides - pharmacology DNA Damage - drug effects DNA fragmentation Dose-Response Relationship, Drug Garlic - chemistry Humans Male prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology |
| title | Growth Suppressing Effect of Garlic Compound Diallyl Disulfide on Prostate Cancer Cell Line (PC-3) in Vitro |
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