Effects of Oxypeucedanin on hKv1.5 and Action Potential Duration

A furocoumarin derivative, oxypeucedanin, was purified from Angelica dahurica, and its effects on the human Kv1.5 (hKv1.5) channel and on the cardiac action potential duration (APD), were examined using the patch-clamp technique and the conventional microelectrode technique. Oxypeucedanin inhibited...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2005, Vol.28(4), pp.657-660
Hauptverfasser:	Eun, Jae Soon, Park, Jung Ah, Choi, Bok Hee, Cho, Sun Kyung, Kim, Dae Keun, Kwak, Yong Geun
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Angelica Angelica dahurica Animals antiarrhythmic drug Cell Line Dose-Response Relationship, Drug Furocoumarins - chemistry Furocoumarins - pharmacology Heart - physiology hKv1.5 channel blocker Humans In Vitro Techniques Molecular Structure oxypeucedanin Potassium Channel Blockers - chemistry Potassium Channel Blockers - pharmacology Potassium Channels, Voltage-Gated - drug effects Potassium Channels, Voltage-Gated - physiology Rats
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