GABA(A) receptors of cerebellar granule cells in culture: explanation of overall insensitivity to ethanol

GABA-activated chloride currents were studied in cerebellar granule cells put in culture from neonatal rats. As previously described, 10 microM GABA perfusion of these cells recorded by whole cell patch-clamp elicits chloride currents displaying a peak and a steady-state component. The two component...

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Veröffentlicht in:	Neuroscience 2009-09, Vol.162 (4), p.1187-1191
Hauptverfasser:	Gatta, E, Cupello, A, Pellistri, F, Robello, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Cations, Divalent Cells, Cultured Cerebellum - cytology Chloride Channels - physiology Chlorides - pharmacology Ethanol - pharmacology Furosemide - pharmacology GABA-A Receptor Antagonists Neurons - drug effects Neurons - physiology Patch-Clamp Techniques Protein Subunits - physiology Rats Receptors, GABA-A - physiology Zinc Compounds - pharmacology
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