Potent Antitumor Effect of Interleukin-24 Gene in the Survivin Promoter and Retinoblastoma Double-Regulated Oncolytic Adenovirus

Interleukin (IL)-24 is an excellent therapeutic gene for cancer therapy. In this work, IL-24 was inserted into Ad.sp-E1A(Delta24), an oncolytic adenovirus with a 24-bp deletion in the E1A gene, which was driven by the survivin promoter to form Ad.sp-E1A(Delta24)-IL-24. Ad.sp-E1A(Delta24)-IL-24 has a...

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Veröffentlicht in:	Human gene therapy 2009-08, Vol.20 (8), p.818-830
Hauptverfasser:	Zhang, Kang Jian, Wang, Yi Gang, Cao, Xin, Zhong, Su Yang, Wei, Rui Cheng, Wu, Yu Mei, Yue, Xue Tian, Li, Gong Chu, Liu, Xin Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - physiology Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Apoptosis Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Care and treatment Cell Line, Tumor Cell Proliferation Cell Survival Cellular proteins Cytopathogenic Effect, Viral - immunology Fundamental and applied biological sciences. Psychology Gene therapy Genetic aspects Genetic Therapy Health aspects Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Inhibitor of Apoptosis Proteins Interleukins Interleukins - genetics Interleukins - therapeutic use Medical sciences Mice Microtubule-Associated Proteins - genetics Oncolytic Virotherapy Oncolytic Viruses - genetics Oncolytic Viruses - physiology Physiological aspects Promoter Regions, Genetic - genetics Retinoblastoma Retinoblastoma Protein - genetics Transfusions. Complications. Transfusion reactions. Cell and gene therapy Virus Replication Xenograft Model Antitumor Assays
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