3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study
The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate...
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| Veröffentlicht in: | European radiology 2005-04, Vol.15 (4), p.653-660 |
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| creator | Lichy, Matthias P Pintaske, Jörg Kottke, Raimund Machann, Jürgen Anastasiadis, Aristotelis Roell, Stefan Hennenlotter, Jörg Diergarten, Till Schick, Fritz Stenzl, Arnulf Claussen, Claus D Schlemmer, Heinz-Peter |
| description | The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils. |
| doi_str_mv | 10.1007/s00330-004-2547-2 |
| format | Article |
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Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-004-2547-2</identifier><identifier>PMID: 15627193</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arrays ; Biopsy ; Choline ; Creatine ; Feasibility Studies ; Histology ; Humans ; Hyperplasia ; Image quality ; Magnetic resonance imaging ; Magnetic Resonance Spectroscopy - methods ; Male ; Malignancy ; Medical imaging ; Middle Aged ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - metabolism ; Protons ; Radiation therapy ; Retrospective Studies ; Signal quality ; Signal to noise ratio ; Spectroscopic analysis ; Spectroscopy ; Spectrum analysis ; Spine</subject><ispartof>European radiology, 2005-04, Vol.15 (4), p.653-660</ispartof><rights>Springer-Verlag 2004.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-f3c1fe70e0997ad84a6b1bc1ad92ce30611f6ceab0dd14dc944355908628550a3</citedby><cites>FETCH-LOGICAL-c327t-f3c1fe70e0997ad84a6b1bc1ad92ce30611f6ceab0dd14dc944355908628550a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15627193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lichy, Matthias P</creatorcontrib><creatorcontrib>Pintaske, Jörg</creatorcontrib><creatorcontrib>Kottke, Raimund</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Anastasiadis, Aristotelis</creatorcontrib><creatorcontrib>Roell, Stefan</creatorcontrib><creatorcontrib>Hennenlotter, Jörg</creatorcontrib><creatorcontrib>Diergarten, Till</creatorcontrib><creatorcontrib>Schick, Fritz</creatorcontrib><creatorcontrib>Stenzl, Arnulf</creatorcontrib><creatorcontrib>Claussen, Claus D</creatorcontrib><creatorcontrib>Schlemmer, Heinz-Peter</creatorcontrib><title>3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><description>The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arrays</subject><subject>Biopsy</subject><subject>Choline</subject><subject>Creatine</subject><subject>Feasibility Studies</subject><subject>Histology</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Image quality</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Protons</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Signal quality</subject><subject>Signal to noise ratio</subject><subject>Spectroscopic analysis</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Spine</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUFrFTEQx4Mo7bP2A3iRgOBt60yS3Wy8SautUBGkPYdski0p-5Jnkj28s1-8ebwHgqeBzO83TOZPyHuEKwSQnwsA59ABiI71QnbsFdmg4KxDGMVrsgHFx04qJc7J21KeAUChkGfkHPuBSVR8Q_7yG7rLqaZIf_6mZedtzanYtAuWhq15CvGJpvmAlGqqp9ZE6zNdy6FhaHuMzmTXzBBbN4WFmkrxqqcPNERqlxCDNQvNaa2N-NKc2ZsSprCEum_-6vbvyJvZLMVfnuoFefz-7eH6rrv_dfvj-ut9ZzmTtZu5xdlL8KCUNG4UZphwsmicYtZzGBDnwXozgXMonFVC8L5XMA5s7Hsw_IJ8Os5tv_mz-lL1NhTrl8VEn9aiB9kPowLZwI__gc9pzbHtpjmyYRQMcGwUHinbjlOyn_Uut5PlvUbQh3z0MR_d8tGHfDRrzofT5HXaevfPOAXCXwCFSIsR</recordid><startdate>200504</startdate><enddate>200504</enddate><creator>Lichy, Matthias P</creator><creator>Pintaske, Jörg</creator><creator>Kottke, Raimund</creator><creator>Machann, Jürgen</creator><creator>Anastasiadis, Aristotelis</creator><creator>Roell, Stefan</creator><creator>Hennenlotter, Jörg</creator><creator>Diergarten, Till</creator><creator>Schick, Fritz</creator><creator>Stenzl, Arnulf</creator><creator>Claussen, Claus D</creator><creator>Schlemmer, Heinz-Peter</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200504</creationdate><title>3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study</title><author>Lichy, Matthias P ; Pintaske, Jörg ; Kottke, Raimund ; Machann, Jürgen ; Anastasiadis, Aristotelis ; Roell, Stefan ; Hennenlotter, Jörg ; Diergarten, Till ; Schick, Fritz ; Stenzl, Arnulf ; Claussen, Claus D ; Schlemmer, Heinz-Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-f3c1fe70e0997ad84a6b1bc1ad92ce30611f6ceab0dd14dc944355908628550a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arrays</topic><topic>Biopsy</topic><topic>Choline</topic><topic>Creatine</topic><topic>Feasibility Studies</topic><topic>Histology</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Image quality</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Protons</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Signal quality</topic><topic>Signal to noise ratio</topic><topic>Spectroscopic analysis</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Spine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lichy, Matthias P</creatorcontrib><creatorcontrib>Pintaske, Jörg</creatorcontrib><creatorcontrib>Kottke, Raimund</creatorcontrib><creatorcontrib>Machann, Jürgen</creatorcontrib><creatorcontrib>Anastasiadis, Aristotelis</creatorcontrib><creatorcontrib>Roell, Stefan</creatorcontrib><creatorcontrib>Hennenlotter, Jörg</creatorcontrib><creatorcontrib>Diergarten, Till</creatorcontrib><creatorcontrib>Schick, Fritz</creatorcontrib><creatorcontrib>Stenzl, Arnulf</creatorcontrib><creatorcontrib>Claussen, Claus D</creatorcontrib><creatorcontrib>Schlemmer, Heinz-Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lichy, Matthias P</au><au>Pintaske, Jörg</au><au>Kottke, Raimund</au><au>Machann, Jürgen</au><au>Anastasiadis, Aristotelis</au><au>Roell, Stefan</au><au>Hennenlotter, Jörg</au><au>Diergarten, Till</au><au>Schick, Fritz</au><au>Stenzl, Arnulf</au><au>Claussen, Claus D</au><au>Schlemmer, Heinz-Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study</atitle><jtitle>European radiology</jtitle><addtitle>Eur Radiol</addtitle><date>2005-04</date><risdate>2005</risdate><volume>15</volume><issue>4</issue><spage>653</spage><epage>660</epage><pages>653-660</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The objective of this study was to demonstrate the feasibility of 3D proton MR spectroscopic imaging (MRSI) of the prostate using a standard spine instead of a dedicated endorectal coil at 1.5 T. Twenty-eight patients (25 with biopsy proven prostate cancers and three patients with a benign prostate hyperplasia) were examined. MRI and MRSI were conducted with commercial array surface coils at 1.5 T. Ratios of choline (Cho), creatine (Cr) and citrate (Ci) were calculated for tumour, central and peripheral zone retrospectively, based on axial T2 weighed MR images and histology reports. Prostate cancer was characterized by significantly elevated (Cho+Cr)/Ci ratio compared with non-tumourous prostate tissue. The quality of all proton MR spectra was considered to be good or acceptable in 17/28 patients (61%) and poor in 11/28 (39%) examinations. In 20/25 patients with proven malignancy (80%), MRSI was considered to be helpful for the detection of prostate cancer. In 4/25 patients with proven malignancy (16%) who underwent seed implantation, radiotherapy or hormone deprivation before MR examination spectroscopy was of poor and non-diagnostic quality. MRSI of the prostate is feasible within clinical routine using the spine array surface coil at 1.5 T. It can consequently be applied to patients even with contraindications for endorectal coils. However, spectral quality and signal-to-noise ratio is clearly inferior to 3D MRSI examinations with endorectal coils.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>15627193</pmid><doi>10.1007/s00330-004-2547-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Arrays Biopsy Choline Creatine Feasibility Studies Histology Humans Hyperplasia Image quality Magnetic resonance imaging Magnetic Resonance Spectroscopy - methods Male Malignancy Medical imaging Middle Aged Prostate cancer Prostatic Neoplasms - diagnosis Prostatic Neoplasms - metabolism Protons Radiation therapy Retrospective Studies Signal quality Signal to noise ratio Spectroscopic analysis Spectroscopy Spectrum analysis Spine |
| title | 3D proton MR spectroscopic imaging of prostate cancer using a standard spine coil at 1.5 T in clinical routine: a feasibility study |
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