Dosage balance in gene regulation: biological implications
Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-determination mechanisms indicated a balance phenomenon such that changes of individual chromosomal dosage altered the phenotype more dramatically than changes in ploidy. Recent evidence suggests that a major contribut...
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| Veröffentlicht in: | Trends in genetics 2005-04, Vol.21 (4), p.219-226 |
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| container_title | Trends in genetics |
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| creator | Birchler, James A. Riddle, Nicole C. Auger, Donald L. Veitia, Reiner A. |
| description | Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-determination mechanisms indicated a balance phenomenon such that changes of individual chromosomal dosage altered the phenotype more dramatically than changes in ploidy. Recent evidence suggests that a major contributor to this balance is the behavior of molecular complexes that function in various regulatory processes affecting gene expression. In this article, we discuss the potential contribution of regulatory balance to the control of quantitative traits, hybrid vigor, genome evolution and post-zygotic speciation mechanisms. |
| doi_str_mv | 10.1016/j.tig.2005.02.010 |
| format | Article |
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| subjects | Aneuploidy Animals Biological and medical sciences Biological Evolution Dosage Compensation, Genetic Fundamental and applied biological sciences. Psychology Gene Dosage Gene Expression Regulation - genetics Genetics of eukaryotes. Biological and molecular evolution Humans Molecular and cellular biology Phenotype |
| title | Dosage balance in gene regulation: biological implications |
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