Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

Caspases are intracellular proteases and key initiators and effectors of apoptosis. Here the authors describe fluorescently labeled activity-based probes that allow the noninvasive in vivo monitoring of the kinetics of caspase activity. Approaches to optimize the probes to enhance their specificity...

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Veröffentlicht in:	Nature medicine 2009-08, Vol.15 (8), p.967-973
Hauptverfasser:	Edgington, Laura E, Berger, Alicia B, Blum, Galia, Albrow, Victoria E, Paulick, Margot G, Lineberry, Neil, Bogyo, Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimitotic agents Antineoplastic agents Apoptosis Apoptosis - physiology Biomedical and Life Sciences Biomedicine Cancer Cancer Research Caspases - metabolism Chemotherapy Control Dexamethasone - therapeutic use Diagnostic Imaging - methods Dosage and administration Drug Delivery Systems - methods Enzyme Activation - physiology Enzymes Fluorescence Fluorescent Dyes Humans Infectious Diseases Kinetics Medical imaging Metabolic Diseases Mice Mice, Nude Models, Biological Molecular Medicine Molecular probes Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Neurosciences Optical Phenomena Physiological aspects Probes Rodents technical-report Thymus Gland - metabolism Thymus Gland - pathology Xenograft Model Antitumor Assays
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