Toll-Like Receptor 4 Polymorphisms and Risk of Gram-Negative Bacteremia after Allogeneic Stem Cell Transplantation. A Prospective Pilot Study
The Toll-like receptor 4 (TLR4) gene is a major recognition receptor for lipopolysaccharide (LPS). In a pilot prospective study, we examined the association of 2 TLR4 polymorphisms (Asp299Gly and Thr399Ile) in the donor or the recipient with Gram-negative bloodstream infection (BSI) in 77 allogeneic...
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| Veröffentlicht in: | Biology of blood and marrow transplantation 2009-09, Vol.15 (9), p.1130-1133 |
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| container_title | Biology of blood and marrow transplantation |
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| creator | Yaa, Mensah Nana Paolo, Peterlongo Peter, Steinherz Eric, Pamer G Jaya, Satagopan Papanicolaou, Genovefa Anna |
| description | The Toll-like receptor 4 (TLR4) gene is a major recognition receptor for lipopolysaccharide (LPS). In a pilot prospective study, we examined the association of 2 TLR4 polymorphisms (Asp299Gly and Thr399Ile) in the donor or the recipient with Gram-negative bloodstream infection (BSI) in 77 allogeneic hematopoietic stem cell transplant (HSCT) patients. Heterozygosity at both loci was defined as “risk genotype.” The cumulative incidence of infection was estimated by treating death prior to infection as a competing risk event and compared between relevant groups using a modified chi-square test. Nine patients had the risk genotype based on donor and 5 based on recipient genotype data. Donor risk genotype showed marginal statistical significance (0.06) in univariate analysis, but not in multivariate analysis. A larger study is required to validate our findings and define genetic susceptibility to this serious infection in HSTC patients. |
| doi_str_mv | 10.1016/j.bbmt.2009.04.012 |
| format | Article |
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A Prospective Pilot Study</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><source>Alma/SFX Local Collection</source><creator>Yaa, Mensah Nana ; Paolo, Peterlongo ; Peter, Steinherz ; Eric, Pamer G ; Jaya, Satagopan ; Papanicolaou, Genovefa Anna</creator><creatorcontrib>Yaa, Mensah Nana ; Paolo, Peterlongo ; Peter, Steinherz ; Eric, Pamer G ; Jaya, Satagopan ; Papanicolaou, Genovefa Anna</creatorcontrib><description>The Toll-like receptor 4 (TLR4) gene is a major recognition receptor for lipopolysaccharide (LPS). In a pilot prospective study, we examined the association of 2 TLR4 polymorphisms (Asp299Gly and Thr399Ile) in the donor or the recipient with Gram-negative bloodstream infection (BSI) in 77 allogeneic hematopoietic stem cell transplant (HSCT) patients. Heterozygosity at both loci was defined as “risk genotype.” The cumulative incidence of infection was estimated by treating death prior to infection as a competing risk event and compared between relevant groups using a modified chi-square test. Nine patients had the risk genotype based on donor and 5 based on recipient genotype data. Donor risk genotype showed marginal statistical significance (0.06) in univariate analysis, but not in multivariate analysis. A larger study is required to validate our findings and define genetic susceptibility to this serious infection in HSTC patients.</description><identifier>ISSN: 1083-8791</identifier><identifier>EISSN: 1523-6536</identifier><identifier>DOI: 10.1016/j.bbmt.2009.04.012</identifier><identifier>PMID: 19660727</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bacteremia - etiology ; Bacteremia - genetics ; Bone marrow transplantation ; Genetic Predisposition to Disease ; Gram-Negative Bacteria - growth & development ; Gram-Negative Bacterial Infections - etiology ; Gram-Negative Bacterial Infections - genetics ; Gram-negative infection ; Hematology, Oncology and Palliative Medicine ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Innate immunity ; Multivariate Analysis ; Mutation ; Pilot Projects ; Polymorphism ; Polymorphism, Single Nucleotide ; Prospective Studies ; Toll-like receptor ; Toll-Like Receptor 4 - genetics ; Transplantation, Homologous</subject><ispartof>Biology of blood and marrow transplantation, 2009-09, Vol.15 (9), p.1130-1133</ispartof><rights>American Society for Blood and Marrow Transplantation</rights><rights>2009 American Society for Blood and Marrow Transplantation</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-b9c701defe6d9c1e2a660d5f2a1b99ba52cdf974c08f36ecb0feb5d6751b1293</citedby><cites>FETCH-LOGICAL-c453t-b9c701defe6d9c1e2a660d5f2a1b99ba52cdf974c08f36ecb0feb5d6751b1293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbmt.2009.04.012$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19660727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yaa, Mensah Nana</creatorcontrib><creatorcontrib>Paolo, Peterlongo</creatorcontrib><creatorcontrib>Peter, Steinherz</creatorcontrib><creatorcontrib>Eric, Pamer G</creatorcontrib><creatorcontrib>Jaya, Satagopan</creatorcontrib><creatorcontrib>Papanicolaou, Genovefa Anna</creatorcontrib><title>Toll-Like Receptor 4 Polymorphisms and Risk of Gram-Negative Bacteremia after Allogeneic Stem Cell Transplantation. A Prospective Pilot Study</title><title>Biology of blood and marrow transplantation</title><addtitle>Biol Blood Marrow Transplant</addtitle><description>The Toll-like receptor 4 (TLR4) gene is a major recognition receptor for lipopolysaccharide (LPS). In a pilot prospective study, we examined the association of 2 TLR4 polymorphisms (Asp299Gly and Thr399Ile) in the donor or the recipient with Gram-negative bloodstream infection (BSI) in 77 allogeneic hematopoietic stem cell transplant (HSCT) patients. Heterozygosity at both loci was defined as “risk genotype.” The cumulative incidence of infection was estimated by treating death prior to infection as a competing risk event and compared between relevant groups using a modified chi-square test. Nine patients had the risk genotype based on donor and 5 based on recipient genotype data. Donor risk genotype showed marginal statistical significance (0.06) in univariate analysis, but not in multivariate analysis. A larger study is required to validate our findings and define genetic susceptibility to this serious infection in HSTC patients.</description><subject>Bacteremia - etiology</subject><subject>Bacteremia - genetics</subject><subject>Bone marrow transplantation</subject><subject>Genetic Predisposition to Disease</subject><subject>Gram-Negative Bacteria - growth & development</subject><subject>Gram-Negative Bacterial Infections - etiology</subject><subject>Gram-Negative Bacterial Infections - genetics</subject><subject>Gram-negative infection</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Innate immunity</subject><subject>Multivariate Analysis</subject><subject>Mutation</subject><subject>Pilot Projects</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Toll-like receptor</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Transplantation, Homologous</subject><issn>1083-8791</issn><issn>1523-6536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks-O0zAQxiMEYpeFF-CAfOKWMHb-1RJCKhUsSBVUu71bjj1e3DpxsJOV-hC8Mw6thMSB08zh932amW-y7DWFggJt3h2KruunggHwAqoCKHuSXdOalXlTl83T1MOqzFctp1fZixgPANBWK_48u6K8aaBl7XX2a--dy7f2iOQOFY6TD6QiO-9OvQ_jDxv7SOSgyZ2NR-INuQ2yz7_hg5zsI5KPUk0YsLeSSJM6snbOP-CAVpH7CXuyQefIPsghjk4OU1L5oSBrsgs-jqj-mOys81PCZ316mT0z0kV8dak32f7zp_3mS779fvt1s97mqqrLKe-4aoFqNNhorigymdbRtWGSdpx3smZKG95WClambFB1YLCrddPWtKOMlzfZ27PtGPzPGeMkehtVGlUO6OcoEti0jJYJZGdQpXljQCPGYHsZToKCWDIQB7FkIJYMBFQiZZBEby7uc9ej_iu5HD0B788AphUfLQYRlcVBobYh3URob__v_-EfuXJ2sEq6I54wHvwchnQ8QUVkAsT98gXLEwAHYJSx8jcOQq9V</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Yaa, Mensah Nana</creator><creator>Paolo, Peterlongo</creator><creator>Peter, Steinherz</creator><creator>Eric, Pamer G</creator><creator>Jaya, Satagopan</creator><creator>Papanicolaou, Genovefa Anna</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Toll-Like Receptor 4 Polymorphisms and Risk of Gram-Negative Bacteremia after Allogeneic Stem Cell Transplantation. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Bacteremia - etiology Bacteremia - genetics Bone marrow transplantation Genetic Predisposition to Disease Gram-Negative Bacteria - growth & development Gram-Negative Bacterial Infections - etiology Gram-Negative Bacterial Infections - genetics Gram-negative infection Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation - adverse effects Humans Innate immunity Multivariate Analysis Mutation Pilot Projects Polymorphism Polymorphism, Single Nucleotide Prospective Studies Toll-like receptor Toll-Like Receptor 4 - genetics Transplantation, Homologous |
| title | Toll-Like Receptor 4 Polymorphisms and Risk of Gram-Negative Bacteremia after Allogeneic Stem Cell Transplantation. A Prospective Pilot Study |
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