Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma
Background: Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic factors that influence the clinical outcome of the patient remain a matter of controversy. Patients and Methods: Twenty patients with esophageal carcinosarcoma were referred t...
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| Veröffentlicht in: | Anticancer research 2009-08, Vol.29 (8), p.3375-3380 |
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| creator | SANO, Akihiko SAKURAI, Shinji SANO, Takaaki HOSOYA, Yoshinori ENOMOTO, Takehiko KANDA, Tatsuo AJIOKA, Yoichi OYAMA, Tetsunari KUWANO, Hiroyuki KATO, Hiroyuki SAKAI, Makoto TANAKA, Naritaka INOSE, Takanori SAITO, Kana SOHDA, Makoto NAKAJIMA, Masanobu SAKAMOTO, Kazuha |
| description | Background: Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic
factors that influence the clinical outcome of the patient remain a matter of controversy. Patients and Methods: Twenty patients
with esophageal carcinosarcoma were referred to our institutions. Tissue blocks were reviewed and sections containing both
carcinomatous and sarcomatous components were stained for epithelial and mesenchymal markers and a proliferating cell marker.
The prognosis of the esophageal carcinosarcoma patients was compared with 142 cases of esophageal squamous cell carcinoma.
Results: In the carcinomatous component, the expression of cytokeratin, epithelial membrane antigen, vimentin, smooth muscle
actin, and S100 were detected in 20, 20, 1, 1, and 1 case, respectively, whereas in the sarcomatous component, expression
of these were detected in 4, 2, 18, 15, and 3 cases, respectively. The Ki-67 labeling index of carcinomatous and sarcomatous
components was 35.5% and 41.8%, respectively. The 5-year survival rate was not statistically different between squamous cell
carcinoma and carcinosarcoma (p=0.219). However, for T1 cases only, carcinosarcoma patients had statistically poorer prognosis
than did squamous cell carcinoma patients (p=0.008). Conclusion: The sarcomatous component shows various histological and
immunohisto-chemical forms. In comparison with squamous cell carcinoma patients, carcinosarcoma patients had poorer prognosis
amongst the T1 cases. For the treatment of esophageal carcinosarcoma, it is important to monitor lymph nodes and be watchful
for hematogenous metastasis, as in cases of esophageal squamous cell carcinoma. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_67566705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67566705</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-67ec470544fdb3c608544e3a330f0d4c23006f73e2caca2fc56fdd9765e8d51f3</originalsourceid><addsrcrecordid>eNpFkc1KxDAUhYMozjj6CjIb3RXSpknapZRRBwQ3Cu7CnTSZRJKmJi3i2xt11NW5nPtxf4_QsuRtWXBK8DFa4origmNMF-gspVeMGWsbcooWZctYSWi7RC-ds4OVYYTJBBf2VoJbw9Cvt97PQzA2TUEa5b_9zkAEOamYXSvTOuj1JoXRwF59ZSFKO4SUJXg4RycaXFIXB12h59vNU3dfPDzebbubh8JUrJ0KxpWsOaZ1rfsdkQw3OVQECMEa97WsSJ5ac6IqCRIqLSnTfd9yRlXT01KTFbr-qTvG8DarNAlvk1TOwaDCnATjlLHcIIOXB3DeedWLMVoP8UP83iIDVwcAUt5WRxikTX9clS_LGcH_nLF7826jEsmDc7ksERCrVjSCkPyBT7Kzdxc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67566705</pqid></control><display><type>article</type><title>Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>SANO, Akihiko ; SAKURAI, Shinji ; SANO, Takaaki ; HOSOYA, Yoshinori ; ENOMOTO, Takehiko ; KANDA, Tatsuo ; AJIOKA, Yoichi ; OYAMA, Tetsunari ; KUWANO, Hiroyuki ; KATO, Hiroyuki ; SAKAI, Makoto ; TANAKA, Naritaka ; INOSE, Takanori ; SAITO, Kana ; SOHDA, Makoto ; NAKAJIMA, Masanobu ; SAKAMOTO, Kazuha</creator><creatorcontrib>SANO, Akihiko ; SAKURAI, Shinji ; SANO, Takaaki ; HOSOYA, Yoshinori ; ENOMOTO, Takehiko ; KANDA, Tatsuo ; AJIOKA, Yoichi ; OYAMA, Tetsunari ; KUWANO, Hiroyuki ; KATO, Hiroyuki ; SAKAI, Makoto ; TANAKA, Naritaka ; INOSE, Takanori ; SAITO, Kana ; SOHDA, Makoto ; NAKAJIMA, Masanobu ; SAKAMOTO, Kazuha</creatorcontrib><description>Background: Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic
factors that influence the clinical outcome of the patient remain a matter of controversy. Patients and Methods: Twenty patients
with esophageal carcinosarcoma were referred to our institutions. Tissue blocks were reviewed and sections containing both
carcinomatous and sarcomatous components were stained for epithelial and mesenchymal markers and a proliferating cell marker.
The prognosis of the esophageal carcinosarcoma patients was compared with 142 cases of esophageal squamous cell carcinoma.
Results: In the carcinomatous component, the expression of cytokeratin, epithelial membrane antigen, vimentin, smooth muscle
actin, and S100 were detected in 20, 20, 1, 1, and 1 case, respectively, whereas in the sarcomatous component, expression
of these were detected in 4, 2, 18, 15, and 3 cases, respectively. The Ki-67 labeling index of carcinomatous and sarcomatous
components was 35.5% and 41.8%, respectively. The 5-year survival rate was not statistically different between squamous cell
carcinoma and carcinosarcoma (p=0.219). However, for T1 cases only, carcinosarcoma patients had statistically poorer prognosis
than did squamous cell carcinoma patients (p=0.008). Conclusion: The sarcomatous component shows various histological and
immunohisto-chemical forms. In comparison with squamous cell carcinoma patients, carcinosarcoma patients had poorer prognosis
amongst the T1 cases. For the treatment of esophageal carcinosarcoma, it is important to monitor lymph nodes and be watchful
for hematogenous metastasis, as in cases of esophageal squamous cell carcinoma.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 19661359</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinosarcoma - metabolism ; Carcinosarcoma - mortality ; Carcinosarcoma - pathology ; Esophageal Neoplasms - metabolism ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - pathology ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Survival Rate ; Tumors</subject><ispartof>Anticancer research, 2009-08, Vol.29 (8), p.3375-3380</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21797630$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19661359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANO, Akihiko</creatorcontrib><creatorcontrib>SAKURAI, Shinji</creatorcontrib><creatorcontrib>SANO, Takaaki</creatorcontrib><creatorcontrib>HOSOYA, Yoshinori</creatorcontrib><creatorcontrib>ENOMOTO, Takehiko</creatorcontrib><creatorcontrib>KANDA, Tatsuo</creatorcontrib><creatorcontrib>AJIOKA, Yoichi</creatorcontrib><creatorcontrib>OYAMA, Tetsunari</creatorcontrib><creatorcontrib>KUWANO, Hiroyuki</creatorcontrib><creatorcontrib>KATO, Hiroyuki</creatorcontrib><creatorcontrib>SAKAI, Makoto</creatorcontrib><creatorcontrib>TANAKA, Naritaka</creatorcontrib><creatorcontrib>INOSE, Takanori</creatorcontrib><creatorcontrib>SAITO, Kana</creatorcontrib><creatorcontrib>SOHDA, Makoto</creatorcontrib><creatorcontrib>NAKAJIMA, Masanobu</creatorcontrib><creatorcontrib>SAKAMOTO, Kazuha</creatorcontrib><title>Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic
factors that influence the clinical outcome of the patient remain a matter of controversy. Patients and Methods: Twenty patients
with esophageal carcinosarcoma were referred to our institutions. Tissue blocks were reviewed and sections containing both
carcinomatous and sarcomatous components were stained for epithelial and mesenchymal markers and a proliferating cell marker.
The prognosis of the esophageal carcinosarcoma patients was compared with 142 cases of esophageal squamous cell carcinoma.
Results: In the carcinomatous component, the expression of cytokeratin, epithelial membrane antigen, vimentin, smooth muscle
actin, and S100 were detected in 20, 20, 1, 1, and 1 case, respectively, whereas in the sarcomatous component, expression
of these were detected in 4, 2, 18, 15, and 3 cases, respectively. The Ki-67 labeling index of carcinomatous and sarcomatous
components was 35.5% and 41.8%, respectively. The 5-year survival rate was not statistically different between squamous cell
carcinoma and carcinosarcoma (p=0.219). However, for T1 cases only, carcinosarcoma patients had statistically poorer prognosis
than did squamous cell carcinoma patients (p=0.008). Conclusion: The sarcomatous component shows various histological and
immunohisto-chemical forms. In comparison with squamous cell carcinoma patients, carcinosarcoma patients had poorer prognosis
amongst the T1 cases. For the treatment of esophageal carcinosarcoma, it is important to monitor lymph nodes and be watchful
for hematogenous metastasis, as in cases of esophageal squamous cell carcinoma.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinosarcoma - metabolism</subject><subject>Carcinosarcoma - mortality</subject><subject>Carcinosarcoma - pathology</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1KxDAUhYMozjj6CjIb3RXSpknapZRRBwQ3Cu7CnTSZRJKmJi3i2xt11NW5nPtxf4_QsuRtWXBK8DFa4origmNMF-gspVeMGWsbcooWZctYSWi7RC-ds4OVYYTJBBf2VoJbw9Cvt97PQzA2TUEa5b_9zkAEOamYXSvTOuj1JoXRwF59ZSFKO4SUJXg4RycaXFIXB12h59vNU3dfPDzebbubh8JUrJ0KxpWsOaZ1rfsdkQw3OVQECMEa97WsSJ5ac6IqCRIqLSnTfd9yRlXT01KTFbr-qTvG8DarNAlvk1TOwaDCnATjlLHcIIOXB3DeedWLMVoP8UP83iIDVwcAUt5WRxikTX9clS_LGcH_nLF7826jEsmDc7ksERCrVjSCkPyBT7Kzdxc</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>SANO, Akihiko</creator><creator>SAKURAI, Shinji</creator><creator>SANO, Takaaki</creator><creator>HOSOYA, Yoshinori</creator><creator>ENOMOTO, Takehiko</creator><creator>KANDA, Tatsuo</creator><creator>AJIOKA, Yoichi</creator><creator>OYAMA, Tetsunari</creator><creator>KUWANO, Hiroyuki</creator><creator>KATO, Hiroyuki</creator><creator>SAKAI, Makoto</creator><creator>TANAKA, Naritaka</creator><creator>INOSE, Takanori</creator><creator>SAITO, Kana</creator><creator>SOHDA, Makoto</creator><creator>NAKAJIMA, Masanobu</creator><creator>SAKAMOTO, Kazuha</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090801</creationdate><title>Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma</title><author>SANO, Akihiko ; SAKURAI, Shinji ; SANO, Takaaki ; HOSOYA, Yoshinori ; ENOMOTO, Takehiko ; KANDA, Tatsuo ; AJIOKA, Yoichi ; OYAMA, Tetsunari ; KUWANO, Hiroyuki ; KATO, Hiroyuki ; SAKAI, Makoto ; TANAKA, Naritaka ; INOSE, Takanori ; SAITO, Kana ; SOHDA, Makoto ; NAKAJIMA, Masanobu ; SAKAMOTO, Kazuha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-67ec470544fdb3c608544e3a330f0d4c23006f73e2caca2fc56fdd9765e8d51f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinosarcoma - metabolism</topic><topic>Carcinosarcoma - mortality</topic><topic>Carcinosarcoma - pathology</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANO, Akihiko</creatorcontrib><creatorcontrib>SAKURAI, Shinji</creatorcontrib><creatorcontrib>SANO, Takaaki</creatorcontrib><creatorcontrib>HOSOYA, Yoshinori</creatorcontrib><creatorcontrib>ENOMOTO, Takehiko</creatorcontrib><creatorcontrib>KANDA, Tatsuo</creatorcontrib><creatorcontrib>AJIOKA, Yoichi</creatorcontrib><creatorcontrib>OYAMA, Tetsunari</creatorcontrib><creatorcontrib>KUWANO, Hiroyuki</creatorcontrib><creatorcontrib>KATO, Hiroyuki</creatorcontrib><creatorcontrib>SAKAI, Makoto</creatorcontrib><creatorcontrib>TANAKA, Naritaka</creatorcontrib><creatorcontrib>INOSE, Takanori</creatorcontrib><creatorcontrib>SAITO, Kana</creatorcontrib><creatorcontrib>SOHDA, Makoto</creatorcontrib><creatorcontrib>NAKAJIMA, Masanobu</creatorcontrib><creatorcontrib>SAKAMOTO, Kazuha</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANO, Akihiko</au><au>SAKURAI, Shinji</au><au>SANO, Takaaki</au><au>HOSOYA, Yoshinori</au><au>ENOMOTO, Takehiko</au><au>KANDA, Tatsuo</au><au>AJIOKA, Yoichi</au><au>OYAMA, Tetsunari</au><au>KUWANO, Hiroyuki</au><au>KATO, Hiroyuki</au><au>SAKAI, Makoto</au><au>TANAKA, Naritaka</au><au>INOSE, Takanori</au><au>SAITO, Kana</au><au>SOHDA, Makoto</au><au>NAKAJIMA, Masanobu</au><au>SAKAMOTO, Kazuha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-08-01</date><risdate>2009</risdate><volume>29</volume><issue>8</issue><spage>3375</spage><epage>3380</epage><pages>3375-3380</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Esophageal carcinosarcoma is a very rare neoplasm and its clinicopathological characteristics and the prognostic
factors that influence the clinical outcome of the patient remain a matter of controversy. Patients and Methods: Twenty patients
with esophageal carcinosarcoma were referred to our institutions. Tissue blocks were reviewed and sections containing both
carcinomatous and sarcomatous components were stained for epithelial and mesenchymal markers and a proliferating cell marker.
The prognosis of the esophageal carcinosarcoma patients was compared with 142 cases of esophageal squamous cell carcinoma.
Results: In the carcinomatous component, the expression of cytokeratin, epithelial membrane antigen, vimentin, smooth muscle
actin, and S100 were detected in 20, 20, 1, 1, and 1 case, respectively, whereas in the sarcomatous component, expression
of these were detected in 4, 2, 18, 15, and 3 cases, respectively. The Ki-67 labeling index of carcinomatous and sarcomatous
components was 35.5% and 41.8%, respectively. The 5-year survival rate was not statistically different between squamous cell
carcinoma and carcinosarcoma (p=0.219). However, for T1 cases only, carcinosarcoma patients had statistically poorer prognosis
than did squamous cell carcinoma patients (p=0.008). Conclusion: The sarcomatous component shows various histological and
immunohisto-chemical forms. In comparison with squamous cell carcinoma patients, carcinosarcoma patients had poorer prognosis
amongst the T1 cases. For the treatment of esophageal carcinosarcoma, it is important to monitor lymph nodes and be watchful
for hematogenous metastasis, as in cases of esophageal squamous cell carcinoma.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>19661359</pmid><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinosarcoma - metabolism Carcinosarcoma - mortality Carcinosarcoma - pathology Esophageal Neoplasms - metabolism Esophageal Neoplasms - mortality Esophageal Neoplasms - pathology Female Humans Immunoenzyme Techniques Male Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Survival Rate Tumors |
| title | Clinicopathological and Immunohistochemical Characteristics of Esophageal Carcinosarcoma |
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