Selective responsiveness to common gamma chain cytokines in peripheral blood-derived cytotoxic T lymphocytes induced by Melan-A/MART-1(27-35)targeted active specific immunotherapy

We have comparatively evaluated the proliferative response of CTL induced in metastatic melanoma patients upon immunization against Melan-A/MART-1(27-35) tumor associated antigen (TAA) to IL-2, IL-7 or IL-15 cytokines, sharing a receptor common gamma-chain (c gamma-c cytokines). Twenty-eight CTL clo...

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Veröffentlicht in:	International journal of cancer 2005-06, Vol.115 (2), p.248-255
Hauptverfasser:	von Holzen, Urs, Adamina, Michel, Bolli, Martin, Weber, Walter P, Zajac, Paul, Groeper, Celia, Reschner, Anca, Feder, Chantal, Schumacher, Reto, Marti, Walter, Oertli, Daniel, Heberer, Michael, Spagnoli, Giulio C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism CD8-Positive T-Lymphocytes - immunology Cell Proliferation HLA-A Antigens - metabolism HLA-A2 Antigen Humans Immunologic Memory Immunotherapy Interleukin-15 - immunology Interleukin-15 - metabolism Interleukin-2 - immunology Interleukin-2 - metabolism Interleukin-7 - immunology Interleukin-7 - metabolism MART-1 Antigen Melanoma - immunology Melanoma - secondary Melanoma - therapy Neoplasm Proteins - immunology Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Interleukin-7 - metabolism Skin Neoplasms - immunology Skin Neoplasms - secondary Skin Neoplasms - therapy T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured
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