Quantitative analysis of the expression of the glutamate–aspartate transporter and identification of functional glutamate uptake reveal a role for cochlear fibrocytes in glutamate homeostasis

Abstract There are several subtypes of fibrocyte in the spiral ligament and spiral limbus of the cochlea that may contribute to fluid homeostasis. Immunocytochemical data suggest that these fibrocytes possess the glutamate–aspartate transporter, GLAST, as do supporting cells around the hair cells. H...

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Veröffentlicht in:	Neuroscience 2009-09, Vol.162 (4), p.1307-1321
Hauptverfasser:	Furness, D.N, Lawton, D.M, Mahendrasingam, S, Hodierne, L, Jagger, D.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid - metabolism Biological and medical sciences Cochlea - cytology Cochlea - metabolism Excitatory Amino Acid Transporter 1 - antagonists & inhibitors Excitatory Amino Acid Transporter 1 - biosynthesis Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Glutamic Acid - metabolism Guinea Pigs Homeostasis Immunohistochemistry In Vitro Techniques Mice Neurology Patch-Clamp Techniques Rats Vertebrates: nervous system and sense organs
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