Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of dextromethorphan in rat everted gut sacs

A rapid, sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method was developed for the simultaneous assay of dextromethorphan and its metabolites in tissue culture medium and its intestinal metabolism studied with the rat everted gut sac model. The method was validated in the...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-05, Vol.819 (1), p.105-113
Hauptverfasser:	ARELLANO, C, PHILIBERT, C, DANE A YAKAN, E. N, VACHOUX, C, LACOMBE, O, WOODLEY, J, HOUIN, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Chromatography, Liquid - methods Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP3A Dextromethorphan - analogs & derivatives Dextromethorphan - analysis Dextromethorphan - metabolism Dextrorphan - analysis Dextrorphan - metabolism Fundamental and applied biological sciences. Psychology General pharmacology In Vitro Techniques Intestinal Mucosa - enzymology Intestine, Small - metabolism Male Mass Spectrometry - methods Medical sciences Oxidoreductases, N-Demethylating - metabolism Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity
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