Statistical criteria for the identification of protein active sites using theoretical microscopic titration curves

Theoretical Microscopic Titration Curves (THEMATICS) may be used to identify chemically important residues in active sites of enzymes by characteristic deviations from the normal, sigmoidal Henderson–Hasselbalch titration behavior. Clusters of such deviant residues in physical proximity constitute r...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2005-05, Vol.59 (2), p.183-195
Hauptverfasser:	Ko, Jaeju, Murga, Leonel F., André, Pierrette, Yang, Huyuan, Ondrechen, Mary Jo, Williams, Ronald J., Agunwamba, Akochi, Budil, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Isomerases - chemistry Amino Acid Isomerases - metabolism Animals Aquifex pyrophilus Arginine Kinase - chemistry Arginine Kinase - metabolism Bacteria - enzymology Bacterial Proteins - chemistry Bacterial Proteins - metabolism beta-Lactamases - chemistry beta-Lactamases - metabolism Binding Sites Catalysis Decapoda enzyme function Enzymes - chemistry Enzymes - metabolism Escherichia coli Escherichia coli - enzymology Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism functional genomics Horseshoe Crabs Kinetics Limulus polyphemus Microscopy - methods Models, Statistical THEMATICS Thiobacillus titration
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