A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures
In this randomized trial involving patients with osteoporotic vertebral compression fractures, patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure. Patients who underwent vertebroplasty had impro...
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| Veröffentlicht in: | The New England journal of medicine 2009-08, Vol.361 (6), p.569-579 |
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| creator | Kallmes, David F Comstock, Bryan A Heagerty, Patrick J Turner, Judith A Wilson, David J Diamond, Terry H Edwards, Richard Gray, Leigh A Stout, Lydia Owen, Sara Hollingworth, William Ghdoke, Basavaraj Annesley-Williams, Deborah J Ralston, Stuart H Jarvik, Jeffrey G |
| description | In this randomized trial involving patients with osteoporotic vertebral compression fractures, patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Spontaneous vertebral fractures are associated with pain, disability, and death in patients with osteoporosis. Percutaneous vertebroplasty, the injection of medical cement, or polymethylmethacrylate (PMMA), into the fractured vertebral body has gained widespread acceptance as an effective method of pain relief and has become routine therapy for osteoporotic vertebral fractures. Guidelines recommend vertebroplasty for fractures that have not responded to medical treatment.
1
Typically, the duration of such fractures ranges from several weeks to several months or longer for fractures that have not healed.
Numerous case series and several small, unblinded, nonrandomized, controlled studies have suggested the effectiveness of vertebroplasty in relieving . . . |
| doi_str_mv | 10.1056/NEJMoa0900563 |
| format | Article |
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Patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Spontaneous vertebral fractures are associated with pain, disability, and death in patients with osteoporosis. Percutaneous vertebroplasty, the injection of medical cement, or polymethylmethacrylate (PMMA), into the fractured vertebral body has gained widespread acceptance as an effective method of pain relief and has become routine therapy for osteoporotic vertebral fractures. Guidelines recommend vertebroplasty for fractures that have not responded to medical treatment.
1
Typically, the duration of such fractures ranges from several weeks to several months or longer for fractures that have not healed.
Numerous case series and several small, unblinded, nonrandomized, controlled studies have suggested the effectiveness of vertebroplasty in relieving . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa0900563</identifier><identifier>PMID: 19657122</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Aged ; Back Pain - etiology ; Back Pain - therapy ; Biological and medical sciences ; Bone Cements ; Bone surgery ; Clinical outcomes ; Clinical trials ; Cross-Over Studies ; Disability Evaluation ; Diseases of the osteoarticular system ; Diseases of the osteoarticular system. Orthopedic treatment ; Double-Blind Method ; Female ; Fractures ; Fractures, Compression - complications ; Fractures, Compression - therapy ; General aspects ; Humans ; Injections, Spinal ; Male ; Medical sciences ; Osteoporosis ; Osteoporosis - complications ; Osteoporosis. Osteomalacia. Paget disease ; Outcome Assessment (Health Care) ; Pain Measurement ; Placebo Effect ; Polymethacrylic Acids ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Spinal Fractures - etiology ; Spinal Fractures - therapy ; Spine ; Treatment Failure ; Vertebroplasty - adverse effects ; Vertebroplasty - methods</subject><ispartof>The New England journal of medicine, 2009-08, Vol.361 (6), p.569-579</ispartof><rights>Copyright © 2009 Massachusetts Medical Society. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><rights>2009 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-5826cea7b3d3b6c8d88b7d1ae650b073fbceccf56ed5aaeb4b604dd34d6454eb3</citedby><cites>FETCH-LOGICAL-c564t-5826cea7b3d3b6c8d88b7d1ae650b073fbceccf56ed5aaeb4b604dd34d6454eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa0900563$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223913812?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21816023$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19657122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kallmes, David F</creatorcontrib><creatorcontrib>Comstock, Bryan A</creatorcontrib><creatorcontrib>Heagerty, Patrick J</creatorcontrib><creatorcontrib>Turner, Judith A</creatorcontrib><creatorcontrib>Wilson, David J</creatorcontrib><creatorcontrib>Diamond, Terry H</creatorcontrib><creatorcontrib>Edwards, Richard</creatorcontrib><creatorcontrib>Gray, Leigh A</creatorcontrib><creatorcontrib>Stout, Lydia</creatorcontrib><creatorcontrib>Owen, Sara</creatorcontrib><creatorcontrib>Hollingworth, William</creatorcontrib><creatorcontrib>Ghdoke, Basavaraj</creatorcontrib><creatorcontrib>Annesley-Williams, Deborah J</creatorcontrib><creatorcontrib>Ralston, Stuart H</creatorcontrib><creatorcontrib>Jarvik, Jeffrey G</creatorcontrib><title>A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this randomized trial involving patients with osteoporotic vertebral compression fractures, patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Spontaneous vertebral fractures are associated with pain, disability, and death in patients with osteoporosis. Percutaneous vertebroplasty, the injection of medical cement, or polymethylmethacrylate (PMMA), into the fractured vertebral body has gained widespread acceptance as an effective method of pain relief and has become routine therapy for osteoporotic vertebral fractures. Guidelines recommend vertebroplasty for fractures that have not responded to medical treatment.
1
Typically, the duration of such fractures ranges from several weeks to several months or longer for fractures that have not healed.
Numerous case series and several small, unblinded, nonrandomized, controlled studies have suggested the effectiveness of vertebroplasty in relieving . . .</description><subject>Aged</subject><subject>Back Pain - etiology</subject><subject>Back Pain - therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Cements</subject><subject>Bone surgery</subject><subject>Clinical outcomes</subject><subject>Clinical trials</subject><subject>Cross-Over Studies</subject><subject>Disability Evaluation</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the osteoarticular system. Orthopedic treatment</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fractures</subject><subject>Fractures, Compression - complications</subject><subject>Fractures, Compression - therapy</subject><subject>General aspects</subject><subject>Humans</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Osteoporosis</subject><subject>Osteoporosis - complications</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Outcome Assessment (Health Care)</subject><subject>Pain Measurement</subject><subject>Placebo Effect</subject><subject>Polymethacrylic Acids</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Spinal Fractures - etiology</subject><subject>Spinal Fractures - therapy</subject><subject>Spine</subject><subject>Treatment Failure</subject><subject>Vertebroplasty - adverse effects</subject><subject>Vertebroplasty - methods</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10MlKxEAQBuBGFGdcjl4lCHqL9p7kKMOMCy7gdg29VCBDko7dyWF8elscHBSsS1HwUVX8CB0RfE6wkBcP89t7p3CB48C20JQIxlLOsdxGU4xpnvKsYBO0F8ISxyK82EUTUkiREUqnaHGZPKnOurb-AJu8-Fo1iauSN_ADaO_6RoVhlVTOJ49hANc774baJM993UW58MoMo4dwgHYq1QQ4XPd99LqYv8yu07vHq5vZ5V1qhORDKnIqDahMM8u0NLnNc51ZokAKrHHGKm3AmEpIsEIp0FxLzK1l3EouOGi2j86-9_bevY8QhrKtg4GmUR24MZQyiykIISI8-QOXbvTx51BSygrCckIjSr-R8S4ED1XZ-7pVflUSXH6lW_5KN_rj9dJRt2A3eh1nBKdroIJRTeVVZ-rw4yjJicSUbVzbhrKDZfvPwU-QGY3G</recordid><startdate>20090806</startdate><enddate>20090806</enddate><creator>Kallmes, David F</creator><creator>Comstock, Bryan A</creator><creator>Heagerty, Patrick J</creator><creator>Turner, Judith A</creator><creator>Wilson, David J</creator><creator>Diamond, Terry H</creator><creator>Edwards, Richard</creator><creator>Gray, Leigh A</creator><creator>Stout, Lydia</creator><creator>Owen, Sara</creator><creator>Hollingworth, William</creator><creator>Ghdoke, Basavaraj</creator><creator>Annesley-Williams, Deborah J</creator><creator>Ralston, Stuart H</creator><creator>Jarvik, Jeffrey G</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090806</creationdate><title>A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures</title><author>Kallmes, David F ; Comstock, Bryan A ; Heagerty, Patrick J ; Turner, Judith A ; Wilson, David J ; Diamond, Terry H ; Edwards, Richard ; Gray, Leigh A ; Stout, Lydia ; Owen, Sara ; Hollingworth, William ; Ghdoke, Basavaraj ; Annesley-Williams, Deborah J ; Ralston, Stuart H ; Jarvik, Jeffrey G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-5826cea7b3d3b6c8d88b7d1ae650b073fbceccf56ed5aaeb4b604dd34d6454eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Back Pain - etiology</topic><topic>Back Pain - therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Cements</topic><topic>Bone surgery</topic><topic>Clinical outcomes</topic><topic>Clinical trials</topic><topic>Cross-Over Studies</topic><topic>Disability Evaluation</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the osteoarticular system. Orthopedic treatment</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fractures</topic><topic>Fractures, Compression - complications</topic><topic>Fractures, Compression - therapy</topic><topic>General aspects</topic><topic>Humans</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Osteoporosis</topic><topic>Osteoporosis - complications</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Outcome Assessment (Health Care)</topic><topic>Pain Measurement</topic><topic>Placebo Effect</topic><topic>Polymethacrylic Acids</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Patients who underwent vertebroplasty had improvements in pain and disability measures that were similar to those in patients who underwent a sham procedure.
Spontaneous vertebral fractures are associated with pain, disability, and death in patients with osteoporosis. Percutaneous vertebroplasty, the injection of medical cement, or polymethylmethacrylate (PMMA), into the fractured vertebral body has gained widespread acceptance as an effective method of pain relief and has become routine therapy for osteoporotic vertebral fractures. Guidelines recommend vertebroplasty for fractures that have not responded to medical treatment.
1
Typically, the duration of such fractures ranges from several weeks to several months or longer for fractures that have not healed.
Numerous case series and several small, unblinded, nonrandomized, controlled studies have suggested the effectiveness of vertebroplasty in relieving . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>19657122</pmid><doi>10.1056/NEJMoa0900563</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2009-08, Vol.361 (6), p.569-579 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged Back Pain - etiology Back Pain - therapy Biological and medical sciences Bone Cements Bone surgery Clinical outcomes Clinical trials Cross-Over Studies Disability Evaluation Diseases of the osteoarticular system Diseases of the osteoarticular system. Orthopedic treatment Double-Blind Method Female Fractures Fractures, Compression - complications Fractures, Compression - therapy General aspects Humans Injections, Spinal Male Medical sciences Osteoporosis Osteoporosis - complications Osteoporosis. Osteomalacia. Paget disease Outcome Assessment (Health Care) Pain Measurement Placebo Effect Polymethacrylic Acids Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Spinal Fractures - etiology Spinal Fractures - therapy Spine Treatment Failure Vertebroplasty - adverse effects Vertebroplasty - methods |
| title | A Randomized Trial of Vertebroplasty for Osteoporotic Spinal Fractures |
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