Capillary electrophoretic determination of methotrexate, leucovorin and folic acid in human urine

A simple, rapid and sensitive procedure using capillary zone electrophoresis (CZE) to measure methotrexate, folinic acid and folic acid in human urine has been developed and validated. Optimum separation of methotrexate, folinic acid and folic acid was obtained on a 60 cm x 75 microm capillary using...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-05, Vol.819 (1), p.141-147
Hauptverfasser:	RODRIGUEZ FLORES, J, CASTANEDA PENALVO, G, ESPINOSA MANSILLA, A, RODRIGUEZ GOMEZ, M. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers - urine Drug Stability Electrophoresis, Capillary - methods Folic Acid - isolation & purification Folic Acid - urine Fundamental and applied biological sciences. Psychology General pharmacology Humans Hydrogen-Ion Concentration Leucovorin - isolation & purification Leucovorin - urine Medical sciences Methotrexate - isolation & purification Methotrexate - urine Osmolar Concentration Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Temperature
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