Hydroxyl radical production and oxidative damage induced by cadmium and naphthalene in liver of Carassius auratus
Freshwater goldfish ( Carassius auratus) were exposed to cadmium (Cd) from 0 to 5 mg/L, and naphthalene (NAP) from 0 to 50 mg/L. Twenty-four hours after the exposure, reactive oxygen species (ROS) was trapped by phenyl- tert-butyl nitrone and detected by electron paramagnetic resonance (EPR). Protei...
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| Veröffentlicht in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2005, Vol.140 (1), p.115-121 |
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| creator | Shi, Huahong Sui, Yunxia Wang, Xiaorong Luo, Yi Ji, Liangliang |
| description | Freshwater goldfish (
Carassius auratus) were exposed to cadmium (Cd) from 0 to 5 mg/L, and naphthalene (NAP) from 0 to 50 mg/L. Twenty-four hours after the exposure, reactive oxygen species (ROS) was trapped by phenyl-
tert-butyl nitrone and detected by electron paramagnetic resonance (EPR). Protein carbonyl (PCO) and lipid peroxidation (LPO) content were determined. The activities of superoxide dismutase (SOD) and catalase (CAT) were also measured. The EPR spectra signals were characterized by prominent six-line spectra, which were defined as hydroxyl radical (
OH). As compared to the control group, Cd and NAP significantly induced
OH production marked by the intensity of the prominent spectra at higher concentrations. Both xenobiotics also increased LPO content and PCO content, depending on the concentrations. Either LPO or PCO content showed significant relation with
OH production. Cd increased the activity of SOD and decreased that of CAT at 5 mg/L, and NAP increased the activities of SOD and CAT at 5 mg/L. The results clearly indicated that these two structurally different non-redox cycling xenobiotics could induce
OH generation and result in oxidative damage in liver of
C. auratus, and these effects were concentration-dependent. |
| doi_str_mv | 10.1016/j.cca.2005.01.009 |
| format | Article |
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Carassius auratus) were exposed to cadmium (Cd) from 0 to 5 mg/L, and naphthalene (NAP) from 0 to 50 mg/L. Twenty-four hours after the exposure, reactive oxygen species (ROS) was trapped by phenyl-
tert-butyl nitrone and detected by electron paramagnetic resonance (EPR). Protein carbonyl (PCO) and lipid peroxidation (LPO) content were determined. The activities of superoxide dismutase (SOD) and catalase (CAT) were also measured. The EPR spectra signals were characterized by prominent six-line spectra, which were defined as hydroxyl radical (
OH). As compared to the control group, Cd and NAP significantly induced
OH production marked by the intensity of the prominent spectra at higher concentrations. Both xenobiotics also increased LPO content and PCO content, depending on the concentrations. Either LPO or PCO content showed significant relation with
OH production. Cd increased the activity of SOD and decreased that of CAT at 5 mg/L, and NAP increased the activities of SOD and CAT at 5 mg/L. The results clearly indicated that these two structurally different non-redox cycling xenobiotics could induce
OH generation and result in oxidative damage in liver of
C. auratus, and these effects were concentration-dependent.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/j.cca.2005.01.009</identifier><identifier>PMID: 15792630</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cadmium ; Cadmium - pharmacology ; Carassius auratus ; Dose-Response Relationship, Drug ; Electron paramagnetic resonance ; Goldfish - metabolism ; Hydroxyl radical ; Hydroxyl Radical - metabolism ; Liver - drug effects ; Liver - metabolism ; Naphthalene ; Naphthalenes - pharmacology ; Non-redox cycling ; Oxidative damage ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Reactive oxygen species</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2005, Vol.140 (1), p.115-121</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-756302e7989fb498bb630f1691d86f0bc8d8ebfd6af0c28810cc18842c7513813</citedby><cites>FETCH-LOGICAL-c382t-756302e7989fb498bb630f1691d86f0bc8d8ebfd6af0c28810cc18842c7513813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cca.2005.01.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15792630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Huahong</creatorcontrib><creatorcontrib>Sui, Yunxia</creatorcontrib><creatorcontrib>Wang, Xiaorong</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Ji, Liangliang</creatorcontrib><title>Hydroxyl radical production and oxidative damage induced by cadmium and naphthalene in liver of Carassius auratus</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>Freshwater goldfish (
Carassius auratus) were exposed to cadmium (Cd) from 0 to 5 mg/L, and naphthalene (NAP) from 0 to 50 mg/L. Twenty-four hours after the exposure, reactive oxygen species (ROS) was trapped by phenyl-
tert-butyl nitrone and detected by electron paramagnetic resonance (EPR). Protein carbonyl (PCO) and lipid peroxidation (LPO) content were determined. The activities of superoxide dismutase (SOD) and catalase (CAT) were also measured. The EPR spectra signals were characterized by prominent six-line spectra, which were defined as hydroxyl radical (
OH). As compared to the control group, Cd and NAP significantly induced
OH production marked by the intensity of the prominent spectra at higher concentrations. Both xenobiotics also increased LPO content and PCO content, depending on the concentrations. Either LPO or PCO content showed significant relation with
OH production. Cd increased the activity of SOD and decreased that of CAT at 5 mg/L, and NAP increased the activities of SOD and CAT at 5 mg/L. The results clearly indicated that these two structurally different non-redox cycling xenobiotics could induce
OH generation and result in oxidative damage in liver of
C. auratus, and these effects were concentration-dependent.</description><subject>Animals</subject><subject>Cadmium</subject><subject>Cadmium - pharmacology</subject><subject>Carassius auratus</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electron paramagnetic resonance</subject><subject>Goldfish - metabolism</subject><subject>Hydroxyl radical</subject><subject>Hydroxyl Radical - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Naphthalene</subject><subject>Naphthalenes - pharmacology</subject><subject>Non-redox cycling</subject><subject>Oxidative damage</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Reactive oxygen species</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PxCAQhonR-P0DvBhO3loZulAaT2ajromJFz2TKVBl048VWuP-e1l3E296YgjP-w4zLyEXwHJgIK-XuTGYc8ZEziBnrNojx6BKlYEU1X6qRcEzNhPyiJzEuGQJnIE8JEcgyorLgh2Tj8XahuFr3dKA1hts6SoMdjKjH3qKvaXDl7c4-k9HLXb45qjv07OztF5Tg7bzU_fD9bh6H9-xdf0GoW1SBDo0dI4BY_RTpDgFHKd4Rg4abKM7352n5PX-7mW-yJ6eHx7nt0-ZKRQfs1Kk_3FXVqpq6lml6jrdG5AVWCUbVhtllasbK7FhhisFzBhQasZNKaBQUJySq61vGuhjcnHUnY_GtS32bpiilpsOvCj_BaEsuBDAEwhb0IQhxuAavQq-w7DWwPQmEL3UKRC9CUQz0CmQpLncmU915-yvYpdAAm62gEu7-PQu6Gi869OGfXBm1Hbwf9h_A6usnD0</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Shi, Huahong</creator><creator>Sui, Yunxia</creator><creator>Wang, Xiaorong</creator><creator>Luo, Yi</creator><creator>Ji, Liangliang</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Hydroxyl radical production and oxidative damage induced by cadmium and naphthalene in liver of Carassius auratus</title><author>Shi, Huahong ; Sui, Yunxia ; Wang, Xiaorong ; Luo, Yi ; Ji, Liangliang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-756302e7989fb498bb630f1691d86f0bc8d8ebfd6af0c28810cc18842c7513813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cadmium</topic><topic>Cadmium - pharmacology</topic><topic>Carassius auratus</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electron paramagnetic resonance</topic><topic>Goldfish - metabolism</topic><topic>Hydroxyl radical</topic><topic>Hydroxyl Radical - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Naphthalene</topic><topic>Naphthalenes - pharmacology</topic><topic>Non-redox cycling</topic><topic>Oxidative damage</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Reactive oxygen species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Huahong</creatorcontrib><creatorcontrib>Sui, Yunxia</creatorcontrib><creatorcontrib>Wang, Xiaorong</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Ji, Liangliang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Huahong</au><au>Sui, Yunxia</au><au>Wang, Xiaorong</au><au>Luo, Yi</au><au>Ji, Liangliang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxyl radical production and oxidative damage induced by cadmium and naphthalene in liver of Carassius auratus</atitle><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><date>2005</date><risdate>2005</risdate><volume>140</volume><issue>1</issue><spage>115</spage><epage>121</epage><pages>115-121</pages><issn>1532-0456</issn><eissn>1878-1659</eissn><abstract>Freshwater goldfish (
Carassius auratus) were exposed to cadmium (Cd) from 0 to 5 mg/L, and naphthalene (NAP) from 0 to 50 mg/L. Twenty-four hours after the exposure, reactive oxygen species (ROS) was trapped by phenyl-
tert-butyl nitrone and detected by electron paramagnetic resonance (EPR). Protein carbonyl (PCO) and lipid peroxidation (LPO) content were determined. The activities of superoxide dismutase (SOD) and catalase (CAT) were also measured. The EPR spectra signals were characterized by prominent six-line spectra, which were defined as hydroxyl radical (
OH). As compared to the control group, Cd and NAP significantly induced
OH production marked by the intensity of the prominent spectra at higher concentrations. Both xenobiotics also increased LPO content and PCO content, depending on the concentrations. Either LPO or PCO content showed significant relation with
OH production. Cd increased the activity of SOD and decreased that of CAT at 5 mg/L, and NAP increased the activities of SOD and CAT at 5 mg/L. The results clearly indicated that these two structurally different non-redox cycling xenobiotics could induce
OH generation and result in oxidative damage in liver of
C. auratus, and these effects were concentration-dependent.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15792630</pmid><doi>10.1016/j.cca.2005.01.009</doi><tpages>7</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2005, Vol.140 (1), p.115-121 |
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| subjects | Animals Cadmium Cadmium - pharmacology Carassius auratus Dose-Response Relationship, Drug Electron paramagnetic resonance Goldfish - metabolism Hydroxyl radical Hydroxyl Radical - metabolism Liver - drug effects Liver - metabolism Naphthalene Naphthalenes - pharmacology Non-redox cycling Oxidative damage Oxidative Stress - drug effects Oxidative Stress - physiology Reactive oxygen species |
| title | Hydroxyl radical production and oxidative damage induced by cadmium and naphthalene in liver of Carassius auratus |
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