SH2-containing 5′-Inositol Phosphatase, SHIP2, Regulates Cytoskeleton Organization and Ligand-dependent Down-regulation of the Epidermal Growth Factor Receptor

Phosphoinositide lipid second messengers are integral components of signaling pathways mediated by insulin, growth factors, and integrins. SHIP2 dephosphorylates phosphatidylinositol 3,4,5-trisphosphate generated by the activated phosphatidylinositol 3′-kinase. SHIP2 down-regulates insulin signaling...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2005-04, Vol.280 (13), p.13129-13136
Hauptverfasser:	Prasad, Nagendra K., Decker, Stuart J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Blotting, Western Cell Adhesion Cell Line Cell Line, Tumor Cytoplasm - metabolism Cytoskeleton - metabolism Cytoskeleton - ultrastructure Down-Regulation Endocytosis ErbB Receptors - metabolism Gene Silencing HeLa Cells Humans Immunoprecipitation Insulin - metabolism Ligands Microscopy, Fluorescence Oncogene Protein v-cbl Phosphatidylinositol 3-Kinases - metabolism Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - chemistry Phosphoric Monoester Hydrolases - physiology Protein Binding Protein Structure, Tertiary Retroviridae Proteins, Oncogenic - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction Time Factors Transfection Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!